Progesterone did not have any additional effect on bone mineral density.
📌 3 Key Takeaways
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Objective & Hypothesis:Objective: The effects of various hormone replacement therapies on bone mineral density after 2 years of treatment were evaluated in this study.Methods: A total of 138 patients treated with either conjugated equine estrogen or transdermal 17-(3 estradiol alone or in combination with medroxyprogesterone acetate or dydrogesterone had bone mineral density measurements of the first four lumbar vertebrae by using a Dual X-ray Hologic 1000 quantitative digital radiography densitometer.Results: After 2 years of treatment, a significant increase in spinal bone mineral density was found in all groups.
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Key Findings & Data:No significant differences were found among 6 treatment groups.Conclusion: There were no differences between estrogen replacement therapies and combined hormone replacement therapies.
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Conclusion & Impact:Progesterone did not have any additional effect on bone mineral density.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Menopause · Osteoporosis · Bone mineral density
Abstract
Objective: The effects of various hormone replacement therapies on bone mineral density after 2 years of treatment were evaluated in this study.Methods: A total of 138 patients treated with either conjugated equine estrogen or transdermal 17-(3 estradiol alone or in combination with medroxyprogesterone acetate or dydrogesterone had bone mineral density measurements of the first four lumbar vertebrae by using a Dual X-ray Hologic 1000 quantitative digital radiography densitometer.Results: After 2 years of treatment, a significant increase in spinal bone mineral density was found in all groups. No significant differences were found among 6 treatment groups.Conclusion: There were no differences between estrogen replacement therapies and combined hormone replacement therapies. Progesterone did not have any additional effect on bone mineral density.
ÇELİKKANAT, H., MORÖY, P., SENÖZ, S., ÇETİNDAĞ, İ., GÖKMEN, O. (1996). The effects of various hormone replacement therapy regimens on bone mineral density after 2 years of treatment. Marmara Medical Journal, Cilt: 9 - Sayı: 4, 165–168. https://ajindex.com/articles/284369
References (1)
Lindsay H, Hart DM, Aitken JM, Mac Donald EB, Anderson JB, Clarke AC. Longterm prevention of postmenopausal osteoporosis by oestrogen. Evidence for an increased bone mass after delayed onset of oestrogen treatment Lancet 1976:1 (7968); 1038-1041.