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Journals / Marmara Medical Journal / 2007 / Cilt: 20 - Sayı: 2

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MİTOKONDRİYAL DNA VE KANSER

Cenk ARAL
Ayşe ÖZER
Pages
127–136
DOI
—
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Abstract

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Özet

Mitokondriyal DNA' nın, nükleer DNA' ya kıyasla mutasyonlara daha duyarlı olması ve tamir mekanizmalarının sınırlılığı nedeniyle karsinogenezde rol aldığı öne sürülmüştür. Bu derlemede tiroid, kolorektal, meme ve gastrik kanserlerde, mitokondriyal genom kararsızlığı, mitokondriyal DNA mutasyonlarının apoptozis ile ilişkisi ve mitokondriyal genomdaki değişimler değerlendirilmiştir.Anahtar Kelimeler: Mitokondriyal DNA, Genomik kararsızlık, Apoptozis, Mutasyon, Solid tümörler

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Cite This Article

ARAL, C., ÖZER, A. (2007). -. Marmara Medical Journal, Cilt: 20 - Sayı: 2, 127–136. https://ajindex.com/articles/284142

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