Journals / Marmara Medical Journal / 2017 / Cilt: 30 - Sayı: 3

Effects of maternal intake of n-3 fatty acids on lipid profile and leptin concentration in cord blood

Anne tarafından alınan n-3 yağ asitlerinin kordon kanı lipid profiline ve leptin konsantrasyonuna etkisi

Pages
169–176
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Daily supplementation with n-3 PUFAs might be effective to improve mother and newborn health.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Maternal intake of n-3 long chain polyunsaturated fatty acids (LC-PUFAs) has positive effects on fetal development and pregnancy outcomes.
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Key Findings & Data:In this study, we aimed to evaluate the effects of maternal n-3 LC-PUFAs intake on anthropometric parameters of mother and newborn, the levels of fatty acids (FAs) and leptin in cord blood.
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Conclusion & Impact:Conclusion: Daily supplementation with n-3 PUFAs might be effective to improve mother and newborn health.
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Leptin · Yağ asitleri · Kordon kanı

Abstract

Objectives: Maternal intake of n-3 long chain polyunsaturated fatty acids (LC-PUFAs) has positive effects on fetal development and pregnancy outcomes. Leptin plays an important role in placental transportation of LC-PUFAs. In this study, we aimed to evaluate the effects of maternal n-3 LC-PUFAs intake on anthropometric parameters of mother and newborn, the levels of fatty acids (FAs) and leptin in cord blood. Material and Methods: Thirty-one pregnant women were included. Eighteen were assigned to the control group and 13 received a supplement containing n-3 LC-PUFAs during last trimester of gestation (supplemented group). Physical examinations of the participants were performed and additional data were collected with a questionnaire. FAs and leptin concentrations in cord blood samples were analyzed using gas chromatography-mass spectrometry (GC-MS) and enzyme-linked immunosorbent assay (ELISA) kit respectively. Results: A total amount of n-3 PUFAs significantly increased after treatment. n-6/n-3 PUFAs ratios and leptin levels were lower in the supplemented group (P=0.052, P=0.140 respectively). There were positive correlations between leptin levels and the z scores for birth weight, height and head circumference of the newborns in the control group. The supplementation affected leptin concentration to be positively correlated with n-6/n-3 PUFA ratios. Conclusion: Daily supplementation with n-3 PUFAs might be effective to improve mother and newborn health.

Özet

Amaç: Anne tarafından, n-3 uzun zincirli çoklu doymamış yağ asit (UZ-ÇDYA)’larının alımı, fetal gelişim ve hamilelik sonuçları üzerine pozitif etkilidir. Leptin, UZ-ÇDYA’larının plasentadan geçişinde önemli bir rol alır. Bu çalışmada, anne tarafından alınan UZ-ÇDYA’larının, anne ve yenidoğanın antropometrik ölçümlerine, kordon kanındaki yağ asitlerine ve leptin düzeylerine olan etkilerini araştırmayı amaçladık. Gereç ve Yöntem: Çalışmaya 31 hamile kadın dahil edildi. Bunların 18’i kontrol grubuna alınırken 13’ü hamileliklerinin son trimesteri boyunca, n-3 UZ-ÇDYA içeren bir ilaç aldı (ilaçlı grup). Katılımcıların fizik muayeneleri yapıldı ve bir anket yardımıyla ek veriler elde edildi. Kordon kanındaki yağ asitleri ve leptin konsantrasyonları, sırasıyla gaz kromatograf kütle spektrometri (GC-MS) ve enzim bağlantılı immunosorbent test (ELISA) kiti kullanılarak analiz edildi. Bulgular: Toplam n-3 UZ-ÇDYA’ların miktarı ilaç kullanımıyla anlamlı olarak arttı. İlaçlı grupta n-6/n-3 UZ-ÇDYA’larnın oranı ve leptin düzeyleri daha düşüktü (P=0,052, P=0,140 sırasıyla). Kontrol grubunda, leptin düzeyleri ile yeni doğanların doğum kilosu, boyu ve baş çevresi arasında pozitif ilişki vardı. İlaç kullanımı, leptin konsantrasyonlarını, n-6/n-3 UZ-ÇDYA oranları ile pozitif ilişkili hale getirdi. Sonuç: Günlük n-3 UZ-ÇDYA’larının alımı, anne ve yeni doğan sağlığının iyileşmesinde etkili olabilir.

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Cite This Article

BATIREL, S., BÜYÜKUSLU, N., BEKİROĞLU, N., GARİPAĞAOĞLU, M. (2017). Effects of maternal intake of n-3 fatty acids on lipid profile and leptin concentration in cord blood. Marmara Medical Journal, Cilt: 30 - Sayı: 3, 169–176. https://ajindex.com/articles/283827

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