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Journals / Marmara Pharmaceutical Journal / 2017 / Cilt: 21 - Sayı: 3

Microemulsion Based Bioadhesive Gel of Itraconazole Using Tamarind Gum: In-vitro and Ex-vivo Evaluation

Kailas K MALI
Shashikant C DHAWALE
Remeth J DIAS
Pages
688–700
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These results indicate that the TG containing ME gel may be a used as vehicle for topical delivery of drugs.

📌 3 Key Takeaways

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Objective & Hypothesis:The current study was aimed to formulate and evaluate bioadhesive gel containing microemulsion (ME) of itraconazole (ITZ) and an attempt was made to investigate suitability of tamarind gum (TG) as a gelling agent.
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Key Findings & Data:Ternary phase diagram was constructed using isopropyl myristate (IPM) and oleic acid (OA) as oil phase, tween 80 as surfactant and isopropyl alcohol (IPA) as cosurfactant in order to obtain ME region.
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Conclusion & Impact:These results indicate that the TG containing ME gel may be a used as vehicle for topical delivery of drugs.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

The current study was aimed to formulate and evaluate bioadhesive gel containing microemulsion (ME) of itraconazole (ITZ) and an attempt was made to investigate suitability of tamarind gum (TG) as a gelling agent. The solubility of ITZ in oils, surfactants and co-surfactant was evaluated for the selection of appropriate component. The ratio of surfactant and co-surfactant was optimized by constructing pseudoternary phase diagram. Ternary phase diagram was constructed using isopropyl myristate (IPM) and oleic acid (OA) as oil phase, tween 80 as surfactant and isopropyl alcohol (IPA) as cosurfactant in order to obtain ME region. The optimized ME of ITZ was characterized by its qualitative and quantitative tests and incorporated into polymeric gels of carbopol (CBP), xanthan gum (XG) and TG. The ME based ITZ gels were evaluated for pH, drug content, viscosity, ex-vivo bioadhesion, spreadability and in vitro drug release. Furthermore, antifungal activity of the gels was performed by agar cup diffusion technique using cultures of Candida albicans. ITZ showed maximum solubility in mixture of IPM and OA (1:1). Stable ME was obtained when IPM and OA was taken in the ratio of 1:1 as oil phase, Tween 80 as surfactant and isopropyl alcohol (IPA) as cosurfactant at the weight ratio of 10:45:45. The optimized ME based gels showed pH in the range of 6.11 to 6.48, spreadability in the range of 4.1 to 7.1gm.cm/sec and ex vivo bioadhesion in the range of 65 to 84gm. The viscosity study indicated pseudoplastic behaviour of all ME based gel formulations. Amongst the studied ME gels, TG containing gels exhibited fast and complete drug release at the end of 24h. Formulation F7 containing TG showed wide zone of inhibition and found to be stable for three months. These results indicate that the TG containing ME gel may be a used as vehicle for topical delivery of drugs.

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Cite This Article

MALI, K. K., DHAWALE, S. C., DIAS, R. J. (2017). Microemulsion Based Bioadhesive Gel of Itraconazole Using Tamarind Gum: In-vitro and Ex-vivo Evaluation. Marmara Pharmaceutical Journal, Cilt: 21 - Sayı: 3, 688–700. https://ajindex.com/articles/283645

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References (13)

  1. Jain A, Jain S, Rawat S. Emerging fungal infections among children: A review on its clinical manifestations, diagnosis, and prevention. J Pharm Bioallied Sci 2010;2:314–20.
  2. Chudasama A, Patel V, Nivsarkar M, Vasu Kamala. Investigation of microemulsion system for transdermal delivery of Itraconazole. J Adv Pharm Technol Res 2011;2:30–8.
  3. Alam S, Iqbal Z, Ali A, Khar RK, Ahmad FJ, Akhter S, Talegaonkar S. Microemulsion as a potential transdermal carrier for poorly water soluble antifungal drug itraconazole. J Dispers Sci Technol. 2009;31:84–94.
  4. Kumar N, Shishu. D-optimal experimental approach for designing topical microemulsion of itraconazole: Characterization and evaluation of antifungal efficacy against a standardized Tinea pedis infection model in Wistar rats. Eur J Pharm Sci 2015;67:97–112.
  5. Grant SM, Clissold SP. Itraconazole. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in superficial and systemic mycoses. Drugs 1989;37:310–44.
  6. Ambala R, Vemula SK. Formulation and characterization of ketoprofen emulgels. J Appl Pharm Sci 2015;5:112–7. Mohamed MI. Optimization of chlorphenesin emulgel formulation. AAPS J 2004;6:e26. Khunt DM, Mishra AD, Shah DR. Formulation design & development of piroxicam emulgel. Int J PharmTech Res 2012;4:1332–44. Karasulu HY. Microemulsions as novel drug carriers: the formation, stability, applications and toxicity. Expert Opin Drug Deliv 2008;5:119–36.
  7. Shah VV, Sharma M, Gandhi K, Suthar V, Parikh RK. Quality by Design (QbD) approach for optimization of microemulsion based topical gel. Marmara Pharm J 2016;20:415–24.
  8. Mali KK, Dhawale SC. Design and optimization of modified tamarind gum-based floating-bioadhesive tablets of verapamil hydrochloride. Asian J Pharm 2016;10:2–8.
  9. Boonme P, Kaewbanjong J, Sangduangyang S, Suksawat S, Teeranachaideekul V. Microemulsion-based hydrogels of itraconazole: Evaluation of characteristics and stability. Asian J Pharm Sci 2016;11:98–9.
  10. Shahin M, Hady SA, Hammad M, Mortada N. Novel jojoba oil-based emulsion gel formulations for clotrimazole delivery. AAPS PharmSciTech 2011;12:239–47.
  11. Fouad SA, Basalious EB, El-Nabarawi MA, Tayel SA. Microemulsion and poloxamer microemulsion-based gel for sustained transdermal delivery of diclofenac epolamine using in-skin drug depot: In vitro/in vivo evaluation. Int J Pharm 2013;453:569–78.
  12. Goyal P, Kumar V, Sharma P. Carboxymethylation of Tamarind kernel powder. Carbohydr Polym 2007;69:251–5.
  13. Shaw GS, Uvanesh K, Gautham SN,