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Journals / Marmara Pharmaceutical Journal / 2018 / Cilt: 22 - Sayı: 2

Cerium oxide nanoparticles sensitize non-small lung cancer cell to ionizing radiation

Shima AZİZİ
Arash GHASEMİ
Hossein ASGARİAN-OMRAN
Zohreh ZAL
Azadeh MONTAZERİ
Hooman YAZDANNEJAT
Seyed Jalal HOSSEİNİMEHR
Pages
307–313
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The present study demonstrates that CNPs to be an effective sensitizer on apoptosis and cell death induced by IR in A-549 cells.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Radiotherapy is an important strategy for cancer treatment, but resistance of tumor cells to ionizing radiation (IR) still remains a main challenging issue related to radiotherapy.
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Key Findings & Data:The aim of this study was to evaluate the sensitizing effect of cerium oxide nanoparticles (CNPs) on non-small lung cancer (A-549) cells exposure to IR.
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Conclusion & Impact:The present study demonstrates that CNPs to be an effective sensitizer on apoptosis and cell death induced by IR in A-549 cells.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Radiotherapy is an important strategy for cancer treatment, but resistance of tumor cells to ionizing radiation (IR) still remains a main challenging issue related to radiotherapy. The aim of this study was to evaluate the sensitizing effect of cerium oxide nanoparticles (CNPs) on non-small lung cancer (A-549) cells exposure to IR. A-549 cells were treated with CNPs and exposed to IR at dose 2 Gy. The radiosensitizing effect of CNPs was evaluated by clonogenic assay and flowcytometry. The findings of this study showed that CNPs reduced the frequencies of A-549 colony when these cells were exposed to IR. CNPs treatment prior exposure to IR significantly increased the IR-induced apoptotic incidences in A-549 cells. The present study demonstrates that CNPs to be an effective sensitizer on apoptosis and cell death induced by IR in A-549 cells.

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Cite This Article

AZİZİ, S., GHASEMİ, A., ASGARİAN-OMRAN, H., ZAL, Z., MONTAZERİ, A., YAZDANNEJAT, H., HOSSEİNİMEHR, S. J. (2018). Cerium oxide nanoparticles sensitize non-small lung cancer cell to ionizing radiation. Marmara Pharmaceutical Journal, Cilt: 22 - Sayı: 2, 307–313. https://ajindex.com/articles/283601

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