Brain tumors in pregnancy: 2 case reports

Objective & Hypothesis:We discussed 2 cases of brain tumors in pregnancy to determine the time and indications of surgical intervention, features of obstetrical management of such patients.

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Key Findings & Data:One of these patients was admitted with the symptoms of intra cerebral pressure increase, second patient was admitted for routine obstetrical examination and she had a brain tumor which was diagnosed before the pregnancy.

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Conclusion & Impact:This effect of pregnancy is probably due to impact of increased levels of estrogen and progesterone on their receptors on brain tumor cells.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Gebelik · Östrojenler · Beyin neoplazmları

Abstract

We discussed 2 cases of brain tumors in pregnancy to determine the time and indications of surgical intervention, features of obstetrical management of such patients. One of these patients was admitted with the symptoms of intra cerebral pressure increase, second patient was admitted for routine obstetrical examination and she had a brain tumor which was diagnosed before the pregnancy. We summarized progress and outcome of pregnancy of these 2 patients. Generally, a rapid progression was occur in brain tumors in pregnancy. This effect of pregnancy is probably due to impact of increased levels of estrogen and progesterone on their receptors on brain tumor cells.

Özet

Gebelikte beyin tümörlerine cerrahi müdahale., zamanını, endikasyonlannı ve bu tip hastalarda obstetrik takibin özelliklerini belirlemek amacıyla 2 beyin tümörü olgusu tartışıldı. Hastalardan birisi kafa içi basınç artışı semptomları ile başvururken, diğer hasta gebeliğinden önce beyin tümörü tanısı almış ve rutin gebelik takibine girmiş bir olgu idi. Bu iki olgunun gebeliğinin seyri ve sonlarıma şekli özetlendi. Beyin tümörlerinde genellikle gebelikte hızlı gelişim meydana gelir. Gebeliğin bu etkisi muhtemelen gebelikte artan estrojen ve progesteronun beyin tiimöründeki spesifik reseptörleri üzerinden olmaktadır.

Keywords

Gebelik Östrojenler Beyin neoplazmları Kafa içi basınç Progesteron Pregnancy Estrogens Brain Neoplasms Intracranial Pressure Progesterone

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Cite This Article

GÜÇLÜ, S., ALTUNYURT, S., DEMİR, N. (2000). Brain tumors in pregnancy: 2 case reports. Medical Network Klinik Bilimler ve Doktor, Cilt: 6 - Sayı: 4, 525–527. https://ajindex.com/articles/279219

References (9)

Simon RH. Brain tumors in pregnancy. Semin Neurol 1988;8:214-221
Isla A, Alvarez F, Gonzalez A, Garcia-Grande A, Perez-Alvarez M, Garcia-Blazquez M. Brain tumor and pregnancy. Obstet Gynecol 1997; 89(1): 19-23
Cioffi F, Buric J, Camesecchi S, Roınoli S, Conti P. Spinal meningiomas in pregnancy report of two cases and review of the literature. Eur J Gynaecol Oncol 1996; 17(5): 384-8
Lesch KP, Gross S. Estrogen receptor immunoreactivity in meningiomas. Comparison with the binding activity of estrogen, progesterone, and androgen receptors. J Neurosurg 1987; 67: 237-43
Haas JF, Janish W, Stanezcek W. Newly diagnosed primary intracranial neoplasm in pregnant woman: A population-based assessment. J Neurol Neurosurg Psychiatry 1986; 49: 874-80
Genazzani AR, Gastaldi M, Bidzinska B, Mercuri N, Genazzani AD, Nappi RE, et al. The brain as a target organ of gonadal steroids. Psychoneuroendocrinology 1992: 17(4): 385-90
Tanapat P, Hastings NB, Reeves A.I, Gould E. Estrogen stimulates a transient increase in the number of new neurons in the dentate gyrus of the adult female rat. J Neurosci 1999 15; 19( 14):5 792-801
Carroll RS, Zhang J, Black PM. Expression of estrogen receptors alpha and beta in human meningiomas. J Neurooncol 1999; 42(2): 109-16
Moresco RM, Scheithauer BW, Lucignani G, Lombardi D, Rocca A, Loşa M et al. Oestrogen receptors in meningiomas: a correlative PET and immunohistochemical study. Nucl Med Commun 1997; 18(7): 606-15. 10.Ismail K, Coakham HB, Walters FJ. Intracranial meningioma with progesterone positive receptors presenting in late pregnancy. Eur J Anaesthesiol 1998; 15(1):106-9.