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Journals / Medical Network Klinik Bilimler ve Doktor / 2002 / Cilt: 8 - Sayı: 3

A randomized comparison of pethidine and morphine for maternal analgesia in active phase of labor

Aktif doğum eyleminde maternal analjezide petidin ve morfin kullanımının randomize karşılaştırılması

Fatih ŞENDAĞ
Mert KAZANDI
Fuat AKERCAN
Mustafa Coşan TEREK
Kemal ÖZTEKİN
Pages
371–373
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further research is needed for the long-term effects of these drugs on the infants.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: To compare the analgesic and side effects of intramuscular pethidine with intramuscular morphine in active phase of labor MATERIAL AND METHODS: Sixty nulliparous women were randomized to receive either 100 mg pethidine or 5 mg intramuscular morphine in active phase of labor.
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Key Findings & Data:RESULTS: More women allocated to receiving pethidine than to diamorphine were found to have higher visual analog scores at the 30th and 60th minutes (p<0.01).
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Conclusion & Impact:Further research is needed for the long-term effects of these drugs on the infants.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Analjezi · obstetrik · Meperidin

Abstract

OBJECTIVE: To compare the analgesic and side effects of intramuscular pethidine with intramuscular morphine in active phase of labor MATERIAL AND METHODS: Sixty nulliparous women were randomized to receive either 100 mg pethidine or 5 mg intramuscular morphine in active phase of labor. All participants received the antiemetic metochlopramide at the same time as the trial drugs. Maternal analgesia asssessed by a visual analog score and verbal scales of pain intensity and pain relief, maternal sedation and vomiting; neonatal outcome assessed by Apgar scores and the need for resuscitation. RESULTS: More women allocated to receiving pethidine than to diamorphine were found to have higher visual analog scores at the 30th and 60th minutes (p<0.01). Slight or no pain relief was reported more frequently in the pethidine compared to morphine group (53.3% versus 26.7%, p=0.03). There was no difference in maternal sedation, but the incidence of vomiting was lower for women who received morphine (p=0.04). Pethidine was associated with lower Apgar scores at 1 minute (p=0.04). CONCLUSION: Intramuscular morphine in labor appears to have some benefits, compared with pethidine. Further research is needed for the long-term effects of these drugs on the infants.

Özet

AMAÇ: Aktif doğum eyleminde intramusküler petidin ve morfin kullanımının maternal analjezi ve yan etkiler açısından karşılaştırılması GEREÇ VE YÖNTEM: Altmış nullipar gebe doğum eyleminin aktif fazında 100 mg petidin ya da 5 mg intramusküler morfin alacak şekilde randomize edildi. Çalışmaya katılan tüm olgulara deneme ilaçları ile eş-zamanlı antiemetik metoklopramid uygulandı. Maternal analjezi vizüel analog skor, ağrı şiddetinin ve azalmasının sözel skalası, maternal sedasyon ve kusma ile; yenidoğan sonuçları Apgar skorları ve resussitasyon gereksinimi ile değerlendirildi. BULGULAR: Petidin kullanılan olgularda morfin kullanılanlara göre ilaçların uygulanmasından sonraki 30. ve 60. dakikalarda vizüel analog skor daha yüksek saptandı (p<0.001). Ağrı giderme etkisinin yok ya da az olması petidin grubunda morfin grubuna göre daha yüksek sıklıkta saptandı (%53.3'e karşılık %26.7, p=0.03). Her iki grupta maternal sedasyon açısından fark yoktu, ancak morfin kullanılan olgularda kusmaya daha az rastlandı (p=0.04). Petidin kullanılan olgularda 1. Dakika düşük Apgar skoru sıklığı daha fazla bulundu (p=0.04). SONUÇ: Aktif doğum eyleminde intramuskuler morfin kullanımının yararları petidin ile karşılaştırıldığında daha fazla görünmektedir. Bebekler üzerindeki uzun-dönem etkileri için ileri araştırmaların yapılması gerekmektedir.

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Cite This Article

ŞENDAĞ, F., KAZANDI, M., AKERCAN, F., TEREK, M. C., ÖZTEKİN, K. (2002). A randomized comparison of pethidine and morphine for maternal analgesia in active phase of labor. Medical Network Klinik Bilimler ve Doktor, Cilt: 8 - Sayı: 3, 371–373. https://ajindex.com/articles/279185

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