SavedAdd your journal

Journals / Medical Network Klinik Bilimler ve Doktor / 2003 / Cilt: 9 - Sayı: 5

Prognostic value of C-reactive protein in colorectal cancer

Kolorektal kanserde C-reaktif proteinin prognostik değeri

Sabahattin ASLAN
Akın ÖNDER
Bahadır ÇETİN
Celal HATİBOĞLU
MELİH AKINCI
Abdullah ÇETİN
Pages
573–576
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Larger series is needed to assess the value of CRP as a prognostic indicator in colorectal cancer.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: To detect prognostic value of C-reactive protein as a biochemical tumor marker in colorectal cancer patients.
📊
Key Findings & Data:Material and Method: 38 colorectal cancer patients operated between November 2001-December 2002 were included in the study.
💡
Conclusion & Impact:Conclusion: Larger series is needed to assess the value of CRP as a prognostic indicator in colorectal cancer.
🔬Design:Research Article
📍Scope:2001 Verileri
⚙️Variables:C-reaktif protein · Seyir · Tümör belirteci

Abstract

Objective: To detect prognostic value of C-reactive protein as a biochemical tumor marker in colorectal cancer patients. Material and Method: 38 colorectal cancer patients operated between November 2001-December 2002 were included in the study. Preoperative simultaneous serum CRP, CEA, CA19-9 levels were obtained in all patients. The patients with diagnosed inflammatory disease were excluded from the study. The relationship between CRP and clinicopathological prognostic parameters was investigated. Results: Seventeen female and 21 male patients with the mean age of 54±13 (min.23, max. 80) were included in the study. According to the primary tumor location; 7 cases were in ascending, 2 in transvers and 22 were in descending colon. Twenty-two of the patients underwent definitive operation, while the remaining were irresectable cases. CRP elevation were detected in 19 patients. There was a significant relationship between elevated CRP levels and CEA, CA 19-9 elevation and presence of ascites. Nonsignificant high CRP levels were detected in patients with hepatic metastases, serosal involvement and stage D. Conclusion: Larger series is needed to assess the value of CRP as a prognostic indicator in colorectal cancer.

Özet

Amaç: Biyokimyasal tümör marker! olarak C-reaktif proteinin (CRP) kolorektal kanserli hastalarda prognostik önemini saptamak. Gereç ve Yöntem: Kasım 2001-Aralık 2002 tarihleri arasında öpere edilen 38 kolorektal kanserli hasta çalışma-ya alındı. Tüm hastalarda eş zamanlı preoperatif serum CRP, CEA, CA19-9 düzeyleri elde edildi. Inflamatuar has-talığı olan olgular çalışma dışı tutuldu. CRP ile klinikopatolojik prognostik faktörler arasındaki ilişki araştırıldı. Bulgular: Yaş ortalaması 54±13 (min. 23, maks. 80) olan 17 kadın, 21 erkek hasta çalışmaya alındı. Olgularda primer tümörün 7'si çıkan kolon, 2'si transvers, 7'si inen kolon, 22'si rektum lokalizasyonluydu. 29 hastaya définitif ameliyat yapılırken, 9 hasta irrezektabl kabul edildi. 19 hastada CRP yüksekliği saptandı. CRP yüksekliği ile CEA, CA19-9 yüksekliği, asit varlığı ve irrezektabl olgular arasında anlamlı istatistiksel sonuç saptandı. Karaciğer metastazı, seroza tutulumu ve evre D deki hastalarda preoperatif CRP yüksekliği daha sık bulunurken aradaki ilişki istatistiksel anlamlı sonuç vermedi. Sonuç: Kolorektal kanserde prognostik indikatör olarak CRP'nin yerini belirlemek için hasta sayısının arttırılarak çalışmaya devam edilmesi gerektiği sonucuna varıldı.

🔖

Cite This Article

ASLAN, S., ÖNDER, A., ÇETİN, B., HATİBOĞLU, C., AKINCI, M., ÇETİN, A. (2003). Prognostic value of C-reactive protein in colorectal cancer. Medical Network Klinik Bilimler ve Doktor, Cilt: 9 - Sayı: 5, 573–576. https://ajindex.com/articles/279143

References (11)

  1. Panatano E, Pisani M, De Jaco MP. Quantitive immunoas- say of C-reactive protein in the postoperative period for the early diagnosis and evaluation of complications (preliminary note). Ric Clin Lab 1980; 10:281-4.
  2. Nozoe T, Matsumata T, Kitamura M, Sugimachi K. Signifi­ cance of preoperative evaluation of serum C- reactive protein as an indicator for prognosis in colorectal cancer. Am J Surg 1998; 176:335-8.
  3. Satamatiadis AP, St Toumanidou M, Vyssoulis GP, Mancu- ras AJ. Value of serum acute phase reactant proteins and CEA in the preoperative staging of colorectal cancer. A multivariate analysis. Cancer 1990; 65:2055-7.
  4. Drahovsky D, Dunzendorfer U, Ziegenhagen G, Drahovsky M. Reevaluation of C-reactive protein in cancer sera by radioimmunoassay and radial immunodiffusion. I. Diagnostic value and use in battery of conventional tumor markers. Oncology 1981; 38:286-91.
  5. Yüceyar S, Ertürk S, Dirican A, Cengiz A, Saner H. The role of acute phase reactant proteins, CEA and CA19-9 as a marker in the preoperative staging of colorectal cancer: a prospective clinical study. Int Surg 1996; 81:136-9.
  6. Mercer DW, Talamo TS. Multiple markers of malignancy in sera of patients with colorectal carcinoma. Clin Chem 1985; 31:1824-8.
  7. Durdey P, Williams NS, Brown DA. Serum CEA and acute ıe reactant proteins in the preoperative detection of fixation ılorectal tumors. Br J Surg 1984; 71:881-4.
  8. Mc Millan DJ, Elahi MM, Sattar N, Angerson WJ. surement of the systemic inflammatory response predicts:er specific and noncancer survival in patients with cancer. Cancer 2001; 41:64-9.
  9. Glojnaric I, Casl MT, Simic D, Lukac J. Serum amyloid a îin in colorectal carcinoma. Clin Chem Lab Med 2001; 29-33.
  10. Wigmore SJ, Me Mahhon AJ, Suturgeon GM, Fearon KC. Acute phase protein response, survival and tumor recurrence in patients with colorectal cancer. Br J Surg 2001; 88:255-60.
  11. Mc Millan DJ, Suturgeon C, Leen E, Smith J, Preston T. Effect of extended ibuprofen administration on the acute phase protein response in colorectal cancer patients. Eur J Surg Oncol 1995;21:531-4.