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Journals / Klinik Psikofarmakoloji Bülteni / 2000 / Cilt: 10 - Sayı: 3

Bazal plazma $beta$-endorphin seviyeleri ile major depressif epizodun ağırlığı arasındaki ilişki

The relationship between basal plasma $beta$-endorphin levels and the severity of major depressive episode

Sabahattin MUHTAROĞLU
Mustafa BAŞTÜRK
M. Fatih KARAASLAN
Aslan OĞUZ
Aytül ŞİMŞEK
Mustafa REYHANCAN
Pages
117–120
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Results: Basal plasma values of beta- EP were significantly higher in the patients than in the control subjects (t=2.66 p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Although several studies performed in depressed patients have shown a deficiency in endorphin activity, plasma studies of beta-Endorphin (beta-EP) in depressive disorders have produced conflicting results so far.
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Key Findings & Data:Methods: 36 patients (17 females, 19 males) who were diagnosed to have major depressive episode according to the DSM- IV criteria (mean age ±SD: 48.6±13.2) and admitted to the psychiatric ward of our university teaching hospital and 13 healthy subjects (mean age 38.70±10)participated in the study.
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Conclusion & Impact:Results: Basal plasma values of beta- EP were significantly higher in the patients than in the control subjects (t=2.66 p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Although several studies performed in depressed patients have shown a deficiency in endorphin activity, plasma studies of beta-Endorphin (beta-EP) in depressive disorders have produced conflicting results so far. The aim of the present study was to test the hypothesis that possible changes in basal beta-EP levels are related to severity of major depressive episode. Methods: 36 patients (17 females, 19 males) who were diagnosed to have major depressive episode according to the DSM- IV criteria (mean age ±SD: 48.6±13.2) and admitted to the psychiatric ward of our university teaching hospital and 13 healthy subjects (mean age 38.70±10)participated in the study. They had HAM-D and MADRS scores above 15 and 8, respectively, at the time of evaluation. Morning plasma beta-EP levels were deter mined with standart RIA kits. Results: Basal plasma values of beta- EP were significantly higher in the patients than in the control subjects (t=2.66 p

Özet

Amaç: Depresyonlu hastalarda yapılmış olan çalışmalar endorfin aktivitesinde değişikliği göstermekle beraber, şimdiye kadar olan plazma beta-EP seviyesi çalışmaları çelişkili sonuçlar vermiştir. Bu çalışmanın amacı plazma bazal beta-EP seviyelerindeki muhtemel değişikliklerin major depressif epizodun ağırlığı ile ilişkili olabileceği hipotezini test etmektir. Metod: DSM-IV kriterlerine göre major depressif epizod teşhisi konmuş ve üniversite hastanesinin psikiyatri servisine kabul edilmiş olan 36 hasta (17 kadın, 19 erkek) (ortalamaya ±SD: 48.6 ±13.2) ve 13 sağlıklı kontrol (ort. yaş. 38.70 ±10) çalışmaya dahil edildi. Değerlendirme esnasında onların HAM-D ve MADRS skorları sırasıyla 15 ve 8'in üstündeydi. Sabah plazma beta-EP seviyeleri standart RIA kitleri ile ölçüldü. Bulgular: Hastalarda bazal plazma beta-EP değerleri kontroller dekine göre önemli şekilde yüksekti (t=2.66 p

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Cite This Article

MUHTAROĞLU, S., BAŞTÜRK, M., KARAASLAN, M. F., OĞUZ, A., ŞİMŞEK, A., REYHANCAN, M. (2022). Bazal plazma $beta$-endorphin seviyeleri ile major depressif epizodun ağırlığı arasındaki ilişki. Klinik Psikofarmakoloji Bülteni, Cilt: 10 - Sayı: 3, 117–120. https://ajindex.com/articles/574577

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