Journals / Medical Network Klinik Bilimler ve Doktor / 2002 / Cilt: 8 - Sayı: 5

Postoperative analgesic implications of ketamin-propofol and propofol infusion during modified radical mastectomy operations

Modifiye radikal mastektomi operasyonlarında uygulanan ketamin-propofol ve propofol infüzyonunun postoperatif analjezik gereksinimine etkisi

Pages
592–594
DOI
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⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION: Pain control and postoperative analgesic requirement were more advantageous when propofol combined with ketamine in modified radical mastectomy patients.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: Ketamine can be combined with other anesthetic agents to obtain better analgesia.
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Key Findings & Data:MATERIAL AND METHOD: A total of 20 patients who underwent modified radical mastectomy randomly divided into two groups.
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Conclusion & Impact:CONCLUSION: Pain control and postoperative analgesic requirement were more advantageous when propofol combined with ketamine in modified radical mastectomy patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Analjezi · Anestezikler · Ketamin

Abstract

OBJECTIVE: Ketamine can be combined with other anesthetic agents to obtain better analgesia. The aim of the study was to evaluate the differences in postoperative analgesic need between ketamine-propofol and propofol only infusion during modified radical mastectomy operations. MATERIAL AND METHOD: A total of 20 patients who underwent modified radical mastectomy randomly divided into two groups. In group I, 1 mg/kg propofol and 0.5 mg/kg ketamine and in group II, propofol 2 mg/kg were given iv bolus for induction. Maintenance doses were 80 mcg/kg/min propofol and 15 mcg/kg/min ketamine in group I and 150 mcg/kg/min propofol in group II. Vecuronium was the neuromuscular blocking agent in both groups. Lung ventilation was performed with 50% N2O and 50% oxygen. Hemodynamic changes during operations and postoperative pain level assessment with visual analog scale and analgesic need were recorded. RESULTS: Patients characteristics were similar. First patient controlled analgesia requirement have been significantly later in ketamine-propofol group (p<0.05). Ketamine and propofol group displayed less total morphine consumption and visual analog scale values at 2. and 4. hour than propofol group (p<0.05). CONCLUSION: Pain control and postoperative analgesic requirement were more advantageous when propofol combined with ketamine in modified radical mastectomy patients.

Özet

AMAÇ: Ketamin analjezi sağlamak için diğer anestezik ajanlarla kombine kullanılabilir. Bu amaçla modifiye radikal mastektomilerde ketaminin propofolle birlikte kullanıldığı olgularla propofolün tek başına kullanıldığı olgulara göre postoperatif ağrı ve analjezik gereksiniminin azalıp azalmadığını değerlendirdik GEREÇ VE YÖNTEM : Modifiye radikal mastektomi uygulanan 20 hasta iki gruba ayrılarak indüksiyonda Grup I'e 1 mg/kg propofol ve 0.5 mg/kg ketamin iv, Grup II'ye 2 mg/kg propofol uygulandı. Anestezi idamesinde Grup I'e 80 mcg/kg/dk propofol ve 15 mcg/kg/dk ketamin, Grup II'ye 150 mcg/kg/dk propofol uygulandı. Nöromüsküler blokaj için vecuronium kullanıldı. Akciğerler % 50 N2O ve % 50 Oksijen ile ventile edildi. Operasyon sırasında hemodinamik değişimler, vizüel analog skala aracılığıyla postoperatif ağrı düzeyleri ve analjezik gereksinimi saptandı. BULGULAR: Hasta karakteristikleri benzerdi. İlk hasta kontrollü analjezi isteği ketamin-propofol grubunda daha geç olmuştur (p<0.05). Toplam morfin tüketimi ve hastaların vizüel analog skala değerleri postoperatif 2 ve 4. saatlerde ketamin grubunda daha düşüktü (p<0.05). SONUÇ: Ketaminin propofolle birlikte kullanıldığı olgularda sadece propofol kullanılanlara göre ağrı kontrolü daha iyi sağlanmakta ve analjezik gereksinimi daha az olmaktadır

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Cite This Article

BATİSLAM, Y. (2002). Postoperative analgesic implications of ketamin-propofol and propofol infusion during modified radical mastectomy operations. Medical Network Klinik Bilimler ve Doktor, Cilt: 8 - Sayı: 5, 592–594. https://ajindex.com/articles/278734

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