Bone metabolism in patients with thyrotoxicosis

Besides normalization of carbonhydrate, lipid and protein meatbolisms, urinary N-telopeptide excretion also decreases along with the increase in bone mineral density.

📌 3 Key Takeaways

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Objective & Hypothesis:AIM: Our aim was to investigate the changes in bone metabolism in patients with newly diagnosed throtoxicosis.

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Key Findings & Data:MATERIAL AND METHOD: 24 patients with newly diagnosed thyrotoxicosis (21 female and 3 male) and 16 healthy controls (all female) were involved in the study.

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Conclusion & Impact:Besides normalization of carbonhydrate, lipid and protein meatbolisms, urinary N-telopeptide excretion also decreases along with the increase in bone mineral density.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Tirotoksikoz · Kan · İdrar

Abstract

AIM: Our aim was to investigate the changes in bone metabolism in patients with newly diagnosed throtoxicosis. MATERIAL AND METHOD: 24 patients with newly diagnosed thyrotoxicosis (21 female and 3 male) and 16 healthy controls (all female) were involved in the study. Patients were administered propylthiouracyl. Bone mineral density, blood biochemistry, and urinary N-telopeptide levels were measured once in the controls, and before initiating and at the sixth month of propylthiouracyl. RESULTS: With treatment TSH, and bone mineral density of the femoral neck significantly increased, while serum ALP, ST<sub>3</sub>, ST<sub>4</sub>, and urinary N-telopeptide significantly decreased in the patients. CONCLUSIONS: Thyroid hormones lead to increase in urinary N-telopeptide levels by increasing bone resorption rate and decreasing bone mineral density. Besides normalization of carbonhydrate, lipid and protein meatbolisms, urinary N-telopeptide excretion also decreases along with the increase in bone mineral density.

Özet

AMAÇ: Bu çalışmadaki amacımız yeni tanı almış tirotoksikozlu hastalarda kemik metabolizmasında değişiklik olup olmadığını araştırmaktı. GEREÇ VE YÖNTEM: Çalışmaya yeni tanı almış 24 tirotoksikozlu hasta (21 kadın, 3 erkek) ile 16 sağlıklı kişiden (tümü kadın) oluşan kontrol grubu alındı. Hastalara propiltiyourasil tedavisi verildi. Kontrol grubunda sadece başlangıçta, hasta grubunda ise tedavi başlanmadan önce ve propiltiyourasil tedavisinin altıncı ayında kemik mineral yoğunluğu, kan biyokimyası ve idrar N-telopeptid düzeyleri ölçüldü. BULGULAR: Hastalarda tedavi ile TSH, femur boynu (KMY)'si değerlerinde istatistiksel anlamlı artış; ALP, ST 3 , ST 4 , ve idrar N-telopeptid düzeylerinde ise istatistiksel anlamlı azalma saptandı. Hastaların tedavi öncesi anlamlı yüksek olan idrar N-telopeptid düzeyleri, tedavi sonrasında anlamlı olarak azaldı. SONUÇ: Tiroid hormonları kemik rezorbsiyon hızında artış ile idrarda tip 1 kollagen'in yıkım ürünü olan N-telopeptid artışına yol açarlar. Tedavi sonrasında hem karbohidrat, lipid, protein metabolizmaları normale dönmekte ve hem de kemik mineral yoğunluğunda dramatik artışla birlikte idrarda N-telopeptid atılımında azalma olmaktadır.

Keywords

Tirotoksikoz Kan İdrar Hipertiroidi Kemik yoğunluğu Biyokimya Thyrotoxicosis Blood Urine Hyperthyroidism Bone Density Biochemistry

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Cite This Article

ÇULHA, C., DEMİRBAŞ, B., GÜLER, S., ŞAHİN, İ., KARAKURT, F., TAŞKIN, S., KUTLUTÜRK, F., SERTER, R., ARAL, Y. (2001). Bone metabolism in patients with thyrotoxicosis. Medical Network Klinik Bilimler ve Doktor, Cilt: 7 - Sayı: 4, 429–433. https://ajindex.com/articles/278652

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