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Journals / Medical Network Klinik Bilimler ve Doktor / 2002 / Cilt: 8 - Sayı: 2

Fibronectin levels in chronic active hepatitis and decompansated liver cirrhosis and correlations with liver function tests

Kronik aktif hepatit ile dekompanze karaciğer sirozunda plasma fibronektin düzeyleri ve karaciğerin fonksiyonel durumu ile ilişkisi

Nilüfer BULUT
Hüseyin DEMİRCİ
Özlem YÖRÜK
Osman ERSOY
İ. Safa YILDIRIM
Pages
155–158
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION: Plasma fibronectin levels are important in chronic active hepatitis and decompansated chronic liver disease to determine the severity of the illness and to have an idea about prognosis.

📌 3 Key Takeaways

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Objective & Hypothesis:AIM: The aim of this study was to look for the correlations of plasma fibronectine levels with liver function test in chronic active hepatitis and decompansated chronic liver disease.
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Key Findings & Data:MATERIAL AND METHODS: 14 patients with decompansated chronic liver disease, 14 patients with active hepatitis who had had interferone treatment and as a control group 8 healthy volunteers were included in the study.
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Conclusion & Impact:CONCLUSION: Plasma fibronectin levels are important in chronic active hepatitis and decompansated chronic liver disease to determine the severity of the illness and to have an idea about prognosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Hepatit · kronik · Karaciğer sirozu

Abstract

AIM: The aim of this study was to look for the correlations of plasma fibronectine levels with liver function test in chronic active hepatitis and decompansated chronic liver disease. MATERIAL AND METHODS: 14 patients with decompansated chronic liver disease, 14 patients with active hepatitis who had had interferone treatment and as a control group 8 healthy volunteers were included in the study. Plasma fibronectine values of both groups of patients were compared to control group and with each other, and its diagnostic value was evaluated. RESULTS: Patients who had had cirrhosis had fibronectin levels lower than patients with chronic active hepatitis and control group. However the difference was not statistically significant (p>0.05). No correlation was found between liver function tests and plasma fibronectin levels. CONCLUSION: Plasma fibronectin levels are important in chronic active hepatitis and decompansated chronic liver disease to determine the severity of the illness and to have an idea about prognosis.

Özet

AMAÇ: Bu çalışmada, dekompanze kronik karaciğer hastalığı (KKH) ile kronik aktif hepatitte (KAH) plasma fibronektin düzeyleri ve karaciğerin fonksiyonel durumu arasındaki ilişkiyi incelemeyi amaçladık. GEREÇ VE YÖNTEM: Çalışmaya 14 KKH, interferon tedavisi alan 14 KAH vakası ile sağlıklı kişilerden oluşan sekiz kontrol grubu alındı. Her iki hastalık grubunda da plasma fibronektin değerlerini sağlıklı kişilerden oluşan kontrol grubu ve kendi aralarında karşılaştırdık, tanısal değerini ortaya koyduk. BULGULAR: Sirozlu hasta grubunda plasma fibronektin değerleri, kontrol grubu ve KAH grubundan daha düşük bulundu. Aradaki fark istatistiki açıdan anlamlı değildi (p>0.05). Plasma fibronektin düzeyi ile diğer karaciğer testleri arasında korelasyon saptanmadı. SONUÇ: Plasma fibronektin düzeyi KAH ve KKH da hastalığın şiddetinin belirlenmesi ve prognozun izlenmesini sağlar.

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Cite This Article

BULUT, N., DEMİRCİ, H., YÖRÜK, Ö., ERSOY, O., YILDIRIM, İ. S. (2002). Fibronectin levels in chronic active hepatitis and decompansated liver cirrhosis and correlations with liver function tests. Medical Network Klinik Bilimler ve Doktor, Cilt: 8 - Sayı: 2, 155–158. https://ajindex.com/articles/278616

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