Journals / Meme Sağlığı Dergisi / 2009 / Cilt: 5 - Sayı: 3

Radiation induced broncıolitis obliterans organizing pneumonia (BOOP) syndrome after radiotherapy for breast cancer

Meme kanseri radyoterapisi sonrası gelişen bronşiolitis obliterans organize pnömoni (BOOP) sendromu

Pages
157–161
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We report an early breast cancer patient treated with breast conservation surgery and postoperative breast radiotherapy who later developed BOOP syndrome in both lungs.

📌 3 Key Takeaways

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Objective & Hypothesis:Radiation-induced bronchiolitis obliterans organising pneumonia (BOOP) is a lung disease which is pathologically characterized by the presence of granulation tissue polyps within respiratory bronchioles and alveoler ducts and patchy areas of organizing pneumonia.
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Key Findings & Data:Occurence of radiation injury in the lung outside the tangential fields and appearance of patchy infiltrates in both lungs are characteristic.
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Conclusion & Impact:We report an early breast cancer patient treated with breast conservation surgery and postoperative breast radiotherapy who later developed BOOP syndrome in both lungs.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Bronşiyolitis obliterans · Yaşlı · Kriptojenik organize pnömoni

Abstract

Radiation-induced bronchiolitis obliterans organising pneumonia (BOOP) is a lung disease which is pathologically characterized by the presence of granulation tissue polyps within respiratory bronchioles and alveoler ducts and patchy areas of organizing pneumonia. Etiologic factors include infection, drug administration, collagen vascular disease, hypersensitivity pneumonia, toxic fume inhalation, acute respiratory deficiency syndrome, thyroiditis and radiotherapy and it may also develop idiopathic. Occurence of radiation injury in the lung outside the tangential fields and appearance of patchy infiltrates in both lungs are characteristic. It is assumed that radiation exposure to lung and pleura initiates a lymphocytic stimulation which then triggers a cytokin mediated immunologic reaction and causes the injury in both lungs. We report an early breast cancer patient treated with breast conservation surgery and postoperative breast radiotherapy who later developed BOOP syndrome in both lungs.

Özet

Radyasyona bağlı bronşiolitis obliterans organize pnömoni (BOOP) sendromu patolojik olarak bronşiol ve alveoler kanallarda granülasyon dokusu polipleri ve organize pnömoni yamalı alanları ile karakterize bir akciğer hastalığıdır. İdiopatik gelişebileceği gibi infeksiyon, ilaç reaksiyonları, kollajen vasküler hastalıklar, hipersensitivite pnömonisi, toksik gaz inhalasyonu, akut solunumsal yetmezlik sendromu, tiroidit ve radyoterapi de etyolojik nedenler arasında sayılabilir. Işınlanan akciğer dokusunda görülen radyasyon pnömonisinden farklı olarak alan dışında ve her iki akciğerde de görülebilen bu hastalıkta radyoterapi sahası içinde kalan akciğer ve plevral dokudaki lenfosit stimülasyonu ve salgılanan sitokinlere bağlı aşırı duyarlılık mekanizması sorumlu tutulmaktadır. Erken evre meme kanseri nedeniyle meme koruyucu cerrahi ile postoperatif radyoterapi uygulanmış ve iki akciğerinde toksisite gelişmiş bir olgumuz sunulacaktır.

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Cite This Article

ALÇO, G., DİNÇER, M., ECE, T., İĞDEM, Ş., OKKAN, S. (2009). Radiation induced broncıolitis obliterans organizing pneumonia (BOOP) syndrome after radiotherapy for breast cancer. Meme Sağlığı Dergisi, Cilt: 5 - Sayı: 3, 157–161. https://ajindex.com/articles/278264

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