Journals / Meme Sağlığı Dergisi / 2010 / Cilt: 6 - Sayı: 1

Postoperative adjuvant radiation therapy in male breast cancer: Retrospective evaluation

Erkek meme kanserinde postoperatif adjuvan radyoterapi: Retrospektif değerlendirme

Pages
22–25
DOI
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Discussion: Although none of the prognostic factors mentioned in the literature presented significant, unfavorable eff ects of the positivity of lymph node and performing simple mastectomy was observed on disease free survival.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: Male breast cancer is accounting less than 1% of all breast cancer cases.
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Key Findings & Data:Materials and methods: Twelve adult male with breast cancer patients records, treated between 1999 and 2006 were evaluated retrospectively.
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Conclusion & Impact:Discussion: Although none of the prognostic factors mentioned in the literature presented significant, unfavorable eff ects of the positivity of lymph node and performing simple mastectomy was observed on disease free survival.
🔬Design:Research Article
📍Scope:2006 Verileri
⚙️Variables:Domain Parameters

Abstract

Introduction: Male breast cancer is accounting less than 1% of all breast cancer cases. Evaluation of charactheristics, treatment response and possible prognostic factors of irradiated (RT) male patients with breast cancer was aimed. Materials and methods: Twelve adult male with breast cancer patients records, treated between 1999 and 2006 were evaluated retrospectively. Disease free survival (DFS) was performed from end of RT. Results: Mean age of patients were 59. Application complaint was painless mass under the areola in all of them. Pathological diagnosis were done after excisional biopsy in the nine patients, after mastectomy in the three of them. In the seven patients lesion was localised in the left breast. Radical modified mastectomy was performed to the eight patients, simple mastectomy to the four of all and axillary dissection were added to the two of these. ER was positive in the nine patients, PR was positive in the eight patients. Two of all had a family history. Median dose of postoperative adjuvant RT was 56 Gy. Median followup was 6.4 years. Median DFS was 4,12 years. DFS rate for 2 years was 6%. DFS rate for 5 years was 65%. During follow-up, local recurrens was evaluated in the one patient and distant metastasis in the four patients. Discussion: Although none of the prognostic factors mentioned in the literature presented significant, unfavorable eff ects of the positivity of lymph node and performing simple mastectomy was observed on disease free survival.

Özet

Giriş: Erkek meme kanseri tüm meme kanseri olgularının %1'inden azını oluşturmaktadır. Radyoterapi (RT) uygulanmış erkek meme kanserli hastaların özellikleri, tedavi cevabı ve olası prognostik faktörleri değerlendirmek amaçlanmıştır. Yöntem ve gereçler: 1999 ile 2006 yılları arasında tedavi edilen 12 erişkin erkek meme kanserli hastanın kayıtları retrospektif olarak değerlendirildi. Hastalıksız sağkalım (HS) analizleri RT bitişinden itibaren yapıldı. Bulgular: Hastaların yaşı medyan 59'idi. Başvuru şikâyeti tümünde areola altında ağrısız kitleydi. Patolojik tanı dokuz hastada eksizyonel biyopsi, üçünde mastektomi sonrası konuldu. Lezyon yedisinde sol meme yerleşimliydi. Sekiz hastaya modifiye radikal mastektomi, dördüne simple mastektomi yapıldı ve bunlardan iki tanesine aksiller diseksiyon eklendi. Dokuz hastada ER pozitif, sekiz hastada PR pozitif idi. Hastalardan ikisinde aile öyküsü vardı. Cerrahi sonrası adjuvan RT medyan dozu 56 Gy'di. Ortalama izlem süresi 6.4 yıl idi. HS medyan 4,12 yıldı. HS oranları 2 yıllık %6 idi. Beş yıllık HS oranı ise %65 idi. İzlemde bir hastada lokal nüks, dördünde uzak metastaz tespit edildi. Tartışma: Literatürde belirtilen prognostik faktörlerden hiçbiri anlamlı bulunmamasına rağmen lenf nodu pozitifliği ve simple mastektomi yapılmasının HS üzerinde olumsuz etkileri gözlendi.

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Cite This Article

İREN, S., ERKAL, E. Y., BORA, H., AKMANSU, M., PAK, Y. (2010). Postoperative adjuvant radiation therapy in male breast cancer: Retrospective evaluation. Meme Sağlığı Dergisi, Cilt: 6 - Sayı: 1, 22–25. https://ajindex.com/articles/278161

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