Journals / Meme Sağlığı Dergisi / 2014 / Cilt: 10 - Sayı: 3

Breast Carcinosarcomas

Meme Karsinosarkomları

Pages
161–165
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The overall survival rate was 53.3% (±20.5).

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Carcinosarcomas of the breast are rare and aggressive breast tumors.
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Key Findings & Data:The optimal treatment strategies and the classification of these difficult to diagnose tumors are not clear in the literature due to their very low incidence.
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Conclusion & Impact:The overall survival rate was 53.3% (±20.5).
🔬Design:Research Article
📍Scope:2000 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Carcinosarcomas of the breast are rare and aggressive breast tumors. The optimal treatment strategies and the classification of these difficult to diagnose tumors are not clear in the literature due to their very low incidence. In this study, we aimed to evaluate patients who were operated on for breast carcinosarcoma and discuss the current literature. Materials and Methods: Ten patients who were treated with a diagnosis of breast carcinosarcoma between January 2000-March 2013 at the Izmir Bozyaka Teaching and Training Hospital General Surgery Clinics were retrospectively analyzed. Results: The mean age of the patients was 59.7 (±13.4) years. Eight patients underwent modified radical mastectomy, one patient lumpectomy and one patient breast conserving surgery + sentinel lymph node biopsy procedures. The TNM stage of patients were identified as stage 1 in 2 patients, stage 2 in 6 patients, and stage 3 in 2 patients. 60-month disease-free survival rate was 52.5% (±18.6). The overall survival rate was 53.3% (±20.5). Four patients died during follow-up. Conclusion: It is reported that the prognosis of carcinosarcomas are as poor as triple negative epithelial tumors. In contrast to the literature, in our study the disease-free and overall survival rates according to stage were not different from epithelial tumors. In this regard, prospective studies including more patients are required.

Özet

Amaç: Meme karsinosarkomları nadir görülen agresif meme tümörleridir. Klinik tanısı zor olan bu tümörlerin insidansının çok düşük olması nedeniyle optimal tedavi stratejisi ve sınıflaması konusunda literatür yetersiz kalmaktadır. Bu çalışmamızda meme karsinosarkomu nedeniyle opere edilen olgularımızı değerlendirmek ve güncel literatür eşliğinde tartışmak amaçlanmıştır. Yöntem ve Gereçler: Ocak 2000 - Mart 2013 yılları arasında İzmir Bozyaka Eğitim ve Araştırma Hastanesi Genel Cerrahi kliniğinde tedavi edilen 10 meme karsinosarkom olgusu retrospektif olarak incelendi. Bulgular: Hastaların yaş ortalaması 59,7 (±13,4) idi. Hastaların 8’ine modifiye radikal mastektomi, 1 hastaya lumpektomi ve 1 hastaya ise meme koruyucu cerrahi + sentinel lenf nodu biopsisi operasyonu uygulandı. Hastaların TNM evreleri; 2 hasta Evre 1, 6 hasta Evre 2, 2 hasta ise Evre 3 olarak saptandı. Hastaların 60 aylık hastalıksız sağkalım oranı %52,5 (±18,6); genel sağkalım oranı %53,3 (±20,5) olarak bulundu. İzlemde 4 hasta hayatını kaybetti. Sonuç: Karsinosarkomların prognozunun triple negatif epitelial tümörler gibi kötü olduğu bildirilse de literatürün aksine bizim çalışmamızda evreye bağlı hastalıksız ve genel sağkalım oranlarının epitelial tümörlerden farklı olmadığı bulunmuştur. Bu konuda hasta sayısı fazla prospektif çalışmalara ihtiyaç vardır.

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Cite This Article

YAKAN, S., SARI, E., ERKAN, N., YILDIRIM, M., VARDAR, E., COŞKUN, A., ÇETİN, D. A., ELİYATKIN, N. (2014). Breast Carcinosarcomas. Meme Sağlığı Dergisi, Cilt: 10 - Sayı: 3, 161–165. https://ajindex.com/articles/278011

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