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Journals / Medicine Science / 2017 / Cilt: 6 - Sayı: 1

Yeni nesil dizilemenin adli bilimlerde kullanımı

Application of next generation sequencing in forensic science

GÖNÜL FİLOĞLU TÜFEK
Irmak SAH
Muhammed DOĞAN
Sila Bulut NALCAOGLU
ÖZLEM BÜLBÜL
Ilksen TAVACİ
TUĞBA ÜNSAL SAPAN
Pages
157–162
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This review has been written to focus on NGS technologies in forensic genetics applications and to be a reference study for next forensic researchers

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Next Generation Sequencing (NGS) Technology has been emerged and started to use in genetic research since the 2000s.
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Key Findings & Data:Until today, various methods which are faster, high throughput and low cost have been developed.
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Conclusion & Impact:This review has been written to focus on NGS technologies in forensic genetics applications and to be a reference study for next forensic researchers
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Next Generation Sequencing (NGS) Technology has been emerged and started to use in genetic research since the 2000s. Until today, various methods which are faster, high throughput and low cost have been developed. NGS Technologies have been gradually developed and the quality of sequencing has been reached the high level and forensic genetics labs have moved to this technology for recent years. NGS Technologies provide new opportunities for forensic genetics research. NGS Technologies enable to analysis of many forensic genetic markers (as STRs, SNPs, mRNA) in only one experiment. Besides, NGS technologies are applicable for different practices which are essential in forensic researches. Among these, create of a DNA database, ancestry and phenotype studies, monozygotic twin studies, identification of body fluids and species, forensic microbiology studies can be considered. This review has been written to focus on NGS technologies in forensic genetics applications and to be a reference study for next forensic researchers

Özet

Yeni nesil dizileme teknolojileri (Next Generation Sequencing; NGS) genetik araştırmalarda 2000'li yıllardan itibaren kullanılmaya başlanmıştır. Günümüze kadar daha hızlı, verimli ve düşük maliyetli çeşitli yöntemler geliştirilmiştir. NGS yöntemleri ve platformları gelişerek dizilerin kalitesi artmış ve son yıllarda adli genetik laboratuvarları da bu teknolojiye yönelmiştir. NGS teknolojisi adli genetikte kullanılan birçok sistemin (STRs, SNPs, mRNA) aynı anda tek bir analizle çalışılmasına olanak sağlamaktadır. Ayrıca bu teknoloji ile adli alanda DNA veri tabanı oluşturma, soy ve fenotip belirleme, tek yumurta ikizlerinin ayırt edilmesi, vücut sıvısı ve türlerin tanımlanması ve mikrobiyoloji analizleri yapılabilmektedir. Bu derleme NGS teknolojilerinin adli genetikte olası kullanım alanları üzerine dikkat çekmek ve gelecekteki adli çalışmalar için referans sağlamak amacıyla hazırlanmıştır

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Cite This Article

TÜFEK, G. F., SAH, I., DOĞAN, M., NALCAOGLU, S. B., BÜLBÜL, Ö., TAVACİ, I., SAPAN, T. Ü. (2017). Yeni nesil dizilemenin adli bilimlerde kullanımı. Medicine Science, Cilt: 6 - Sayı: 1, 157–162. https://ajindex.com/articles/277492

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