SavedAdd your journal

Journals / Medicine Science / 2017 / Cilt: 6 - Sayı: 3

The effect of vitamin B12 deficiency on the GH-IGF1 axis

BELMA HALİLOĞLU
GÜLEN TÜYSÜZ KİNTRUP
Avni KAYA
Pages
496–497
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, there is a need for the studies that are performed in children with more severe and long-term B12 deficiency

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Vitamin B12 (B12) deficiency is associated with growth retardation, reduced serum osteocalcin levels, lower bone mineral density, and increased bone fracture risk, yet the underlying mechanisms remain unclear.
📊
Key Findings & Data:However, a recent study showed that B12 positively regulates postweaning growth and bone formation via taurine.
💡
Conclusion & Impact:However, there is a need for the studies that are performed in children with more severe and long-term B12 deficiency
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Vitamin B12 (B12) deficiency is associated with growth retardation, reduced serum osteocalcin levels, lower bone mineral density, and increased bone fracture risk, yet the underlying mechanisms remain unclear. However, a recent study showed that B12 positively regulates postweaning growth and bone formation via taurine. B12 deficiency causes growth hormone resistance (GH) and IGF1 (Insulin-like growth factor-1) deficiency. In the present study, we aimed to evaluate the effect of B12 deficiency on the axis of GH-IGF1 and serum taurine level. Eighteen children with B12 deficiency (B12 düzeyi 20 kg 1000 mcg/day). The mean age of the 18 subjects (6F/12M) was 8.0±4.8 years-old. The levels of serum B12, growth hormone, IGF1, IGFBP3 and taurine before and after oral B12 treatment were 132.6±28.4 pg/ml vs 655.8±384.4 pg/ml, 1.20±1.98 vs 1.35±1.20 ng/ml, 213.9±185.8 vs 217.8±181.5 ng/ml, 3683.5±1497 vs 3583.5±1207.3ng/ml, 32.7±18.0 vs 41.1±30.4 μmol/L (p<0.0001,p=0.41,0.37,0.28 ve 0.31, respectively). The present study did not detect any relation between B12 deficiency and the GH-IGF1 axis. However, there is a need for the studies that are performed in children with more severe and long-term B12 deficiency

🔖

Cite This Article

HALİLOĞLU, B., KİNTRUP, G. T., KAYA, A. (2017). The effect of vitamin B12 deficiency on the GH-IGF1 axis. Medicine Science, Cilt: 6 - Sayı: 3, 496–497. https://ajindex.com/articles/277456

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (7)

  1. Kalhan SC, Marczewski SE. Methionine, homocysteine, one carbon metabolism and fetal growth. Rev Endocr Metab Disord. 2012;13(2):109–19
  2. Stabler SP. Vitamin B12 deficiency. N Engl J Med. 2013;368(21):2041-2
  3. Tucker KL, Hannan MT, Qiao N, Jacques PF, Selhub J, Cupples LA, Kiel DP. Low plasma vitamin B12 is associ- ated with lower BMD: the Framingham Osteopo- rosis Study. J Bone Miner Res. 2005;20(1):152-8
  4. Muthayya S, Kurpad AV, Duggan CP, Bosch RJ, Dwarkanath P, Mhaskar A, Mhaskar R, Thomas A, Vaz M, Bhat S, Fawzi WW. Low maternal vitamin B12 sta- tus is associated with intrauterine growth retarda- tion in urban South Indians. Eur J Clin Nutr. 2006;60(6):791-801
  5. Xian L, Wu X, Pang L, Lou M, Rosen CJ, Qiu T, Crane J, Frassica F, Zhang L, Rodriguez JP, Xiaofeng Jia, Shoshana Yakar, Shouhong Xuan, Argiris Efstratiadis, Mei Wan, Xu Cao. Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells. Nat Med. 2012;18(7):1095–101
  6. Verner A, Craig S, McGuire W. Effect of taurine supplementation on growth and development in preterm or low birth weight infants. Cochrane Data-base Syst Rev. 2007;4:CD006072
  7. Roman-Garcia P, Quiros-Gonzalez I, Mottram L, Lieben L, Sharan K, Wangwiwatsin A, Tubio J, Lewis K, Wilkinson D, Santhanam B, Sarper N, Clare S, Vassiliou GS, Velagapudi VR, Dougan G, Yadav VK. Vitamin B₁₂-dependent taurine synthesis regulates growth and bone mass. J Clin Invest. 2014 Jul;124(7):2988-3002