We report on an AQP4 antibody-positive 12-year-old female with radiological findings in her brain MRI
📌 3 Key Takeaways
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Objective & Hypothesis:Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune demyelinating disorder of the central nervous system that predominantly affects the optic nerves and the spinal cord.
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Key Findings & Data:Specific antibodies against aquaporin-4 (AQP4) were identified and found to be directly responsible for the pathogenesis of the disease.
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Conclusion & Impact:We report on an AQP4 antibody-positive 12-year-old female with radiological findings in her brain MRI
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune demyelinating disorder of the central nervous system that predominantly affects the optic nerves and the spinal cord. Magnetic resonance imaging (MRI) has an increasingly important role in differentiating NMOSD from other inflammatory disorders of the central nervous system, particularly multiple sclerosis (MS). Specific antibodies against aquaporin-4 (AQP4) were identified and found to be directly responsible for the pathogenesis of the disease. We report on an AQP4 antibody-positive 12-year-old female with radiological findings in her brain MRI
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Cite This Article
ARSLAN, M., GÜNGÖR, S., KILIÇ, B., OĞUZ, K. K. (2017). Neuromyelitis optica spectrum disorder: a pediatric case report. Medicine Science, Cilt: 6 - Sayı: 3, 562–566. https://ajindex.com/articles/277418
Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carrol W, Chitnis T, de Seze J, Fujihara K, Greenberg B, Jacob A, Jarius S, Lana-Peixoto M, Levy M, Simon JH, Tenembaum S, Traboulsee AL, Waters P, Wellik KE, Weinshenker BG; International Panel for NMO Diagnosis. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology. 2015;85(2):177-89
Wingerchuk DM, Lennon VA, Lucchetti CF, Pittock SJ, Weinshenker BG. The spectrum of neuromyelitis optica. Lancet Neurol. 2007;6(9):805-15
Melay MA, Wingerchuk DM, Greenberg BM, Levy M. Epidemiology of neuromyelitis optica in the United States:a multicenter analysis. Arch Neurol. 2012;69(9):1176-80
Lennon VA, Wingerchuk DM, Kryzer TJ, Pittock SJ, Lucchinetti CF, Fujihara K, Nakashima I, Weinshenker BG. A serum autoantibody marker of neuromyelitis optica: Distinction from multiple sclerosis. Lancet. 2004;364(9451):2106-12
Wegner C. Recent insights into the pathology of multiple sclerosis and neuromyelitis optica. Clin Neurol Neurosurg. 2013;115(1):38- 41
Huy SY, Min JH, Kim W, Kim BJ, Kim BJ, Lee KH. The usefulness of brain MRI at onset in the differentiation of multipe sclerosis and seropositive euromyelitis optica spectrum disorders. Mult Scler. 2014;20:695-704
Ghezzi A, Bergamashi R, Martinelli V, Trojano M, Tola MR, Merelli E, Mancardi L, Gallo P, Filippi M, Zaffaroni M, Comi G; Italian Devic's Study Group (IDESG). Clinical characteristics, course and prognosis of relapsing Devic’s neuromyelitis optica. J Neurol. 2004;251(1):47-52
Wingerchuk DM, Lennon VA, Pittock SJ, Luncchietti CF, Weinshenker BG. Revised diagnostic criteria for neuromyelitis optica. Neurology. 2006;66(10):1485-9
Pittock SJ, Lennon VA, Krecke K, Wingerchuk DM, Luchinetti CF, Weinshenker BG. Brain abnormalities in neuromyelitis optica. Arch Neurol. 2006;63(3):390-6
Ito S, Mori M, Makino T, Hayakawa S, Kuwabara S. Cloud-like enhancement’ is a magnetic resonance imaging abnormality specific to neuromyelitis optica. Neurology. 2009;66(3):425-8 12. Kim SH, Kim W, Li XF, Jung IJ, Kim HJ. Clinical spectrum of CNS aquaporin-4 autoimmunity. Neurology. 2012;78(15):1179-85
Cassinotto C, Deramod H, Olindo S, Aveillan M, Smadja D, Cabre P. MRI of the spinal cord in neuromyelitis optica and recurrent longitudinal extensive myelitis. J Neururad. 2009;36(4):199-205