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Journals / Medicine Science / 2017 / Cilt: 6 - Sayı: 2

Lymph node evaluation and survival after resection of colorectal cancer

Lütfi SOYLU
Oğuz Uğur AYDIN
Nedim ÇEKMEN
Fuat ATALAY
Pages
182–188
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

LNR is a better prognostic factor in patients with colorectal cancer compared to lymph node stage and number

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Recent studies have demonstrated that lymph nodes ratio (LNR) might provide a significant prognostic role for colorectal cancer.
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Key Findings & Data:This retrospective study included 190 patients (117 males and 73 females).
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Conclusion & Impact:LNR is a better prognostic factor in patients with colorectal cancer compared to lymph node stage and number
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Recent studies have demonstrated that lymph nodes ratio (LNR) might provide a significant prognostic role for colorectal cancer. We retrospectively analyzed the data of the patients with colorectal cancer and assessed a possible correlation between lymph node parameters and survival. We conducted a retrospective chart review of patients who underwent a radical colon surgery involving removal of mesocolic lymph nodes due to colorectal cancer. Prognostic significance of the removed lymph node number (LNs), metastatic LNs, lymph node ratio (LNR) and other factors were compared. This retrospective study included 190 patients (117 males and 73 females). The estimated survival period was found to be 87.70 months [confidence interval (CI) of 95% (80.64-94.76)]. LNR, LNs and N stage were found to have significant correlation with survival. Among these factors, LNR had the biggest correlation (r = 0 .138, P =0.028). Multivariate regression analysis of survival with lymph node parameters showed that LNR and N stage were significantly correlated with survival. However, LNR was found to be the most significant prognostic factor [P >0.0001, 95% CI; 3.12 (1.55-5.75)]. LNR is a better prognostic factor in patients with colorectal cancer compared to lymph node stage and number

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Cite This Article

SOYLU, L., AYDIN, O. U., ÇEKMEN, N., ATALAY, F. (2017). Lymph node evaluation and survival after resection of colorectal cancer. Medicine Science, Cilt: 6 - Sayı: 2, 182–188. https://ajindex.com/articles/277359

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References (13)

  1. Bikhchandani J, Ong GK, Dozois EJ, Mathis KL. Outcomes of salvage surgery for cure in patients with locally recurrent disease after local excision of rectal cancer. Dis Colon Rectum. 2015;58(3):283-7
  2. Radespiel-Tröger M, Hohenberger W, Reingruber B. Improved prediction of recurrence after curative resection of colon carcinoma using tree-based risk stratification. Cancer. 2004;100(5):958-67
  3. Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010;17(6):1471-4
  4. Shia J, Wang H, Nash GM, Klimstra DS. Lymph node staging in colorectal cancer: revisiting the benchmark of at least 12 lymph nodes in R0 resection. J Am Coll Surg. 2012;214(3):348-55
  5. Tsai HL, Lu CY, Hsieh JS, Wu DC, Jan CM, Chai CY, Chu KS, Chan HM, Wang JY. The prognostic significance of total lymph node harvest in patients with T2-4N0M0 colorectal cancer. J Gastrointest Surg. 2007;11(5):660-5
  6. Vather R, Sammour T, Zargar-Shoshtari K, Metcalf P, Connolly A, Hill A. Lymph node examination as a predictor of long term outcome in Dukes B colon cancer. Int J Colorectal Dis. 2009;24(3):283-8
  7. Sigurdson ER. Lymph node dissection: Is it diagnostic or therapeutic? J Clin Oncol. 2003;21(6):965-7
  8. Baxter NN, Virnig DJ, Rothenberger DA, Morris AM, Jessurun J, Virnig BA. Lymph node evaluation in colorectal cancer patients: a population-based study. J Natl Cancer Inst. 2005;97(3):219-25
  9. Wang J, Hassett JM, Dayton MT, Kulaylat MN. Lymph node ratio: role in the staging of node-positive colon cancer. Ann Surg Oncol. 2008;15(6):1600-8
  10. Ghahramani L, Moaddabshoar L, Razzaghi S, Hamedi SH, Pourahmad S, Mohammadianpanah M. Prognostic Value of Total Lymph Node Identified and Ratio of Lymph Nodes in Resected Colorectal Cancer. Ann Colorectal Res. 2013;1(3):81-91
  11. Storli KE, Søndenaa K, Bukholm IR, Nesvik I, Bru T, Furnes B, Hjelmeland B, Iversen KB, Eide GE. Overall survival after resection for colon cancer in a national cohort study was adversely affected by TNM stage, lymph node ratio, gender, and old age. Int J Colorectal Dis. 2011;26(10):1299-307
  12. Sugimoto K, Kawai M, Takehara K, Tashiro Y, Munakata S, Nagayasu K, Niwa K, Ishiyama S, Komiyama H, Takahashi M, Kojima Y, Goto M, Tomiki Y, Sakamoto K. The validity of predicting prognosis by the number of lymph node metastases in node-positive colon cancer. Open Journal of Gastroenterology. 2013; 3(4):217-22
  13. Sadaka E, Maria A, El-S