SavedAdd your journal

Journals / Medicine Science / 2019 / Cilt: 8 - Sayı: 3

Determination of experimentally given homocysteine causes to alzheimer-like dementia in rats on the basis of different parameters

Dosay Mine AKBULUT
Ayhan VURMAZ
Pages
670–676
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Different studies results indicate that; increased plasma homocysteine level was found to be a strongly independent risk factor for the progress of dementia and Alzheimer’s disease.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Alzheimer’s disease (AD) is the most seen form of neurodegenerative disease with specific pathological findings like; senile plaques (CPs), synaptic loss, neurofibrillary tangles (NFTs) and neurodegeneration.
📊
Key Findings & Data:In this study, total 12 rats, were used and divided into 2 groups.
💡
Conclusion & Impact:Different studies results indicate that; increased plasma homocysteine level was found to be a strongly independent risk factor for the progress of dementia and Alzheimer’s disease.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Alzheimer’s disease (AD) is the most seen form of neurodegenerative disease with specific pathological findings like; senile plaques (CPs), synaptic loss, neurofibrillary tangles (NFTs) and neurodegeneration. Homocysteine is a naturally occurring amino acid and have a role on the body’s methylation process. In this study, total 12 rats, were used and divided into 2 groups. Group 1 Control group (n = 6): No rats were treated. Group 2 Application of High-Dose Homocysteine (n = 6): For 5 weeks, 4 mg / kg / day; to create an experimental Alzheimer model. Morris Water Maze test, the MDA, homocysteine (Hcy), reduced glutathione (GSH) and oxidised glutathione (GSSG) levels in rat liver, serum and erythrocyte samples were studied. Mitogen activated protein kinase (MAPK) and beta-secretase (BACE1) mRNA levels and pathological examinations were performed in rat hippocampus samples. The reaching time to exit platform was longer in the Hcy group according to Morris Water Maze test. Neurodegenerative areas were observed in the hippocampus CA1 region of Hcy group. Liver and serum Hcy and MDA levels and liver and erythrocyte GSSG levels were significantly higher (p <0.01) while GSH levels were lower in the liver and erythrocyte samples compared to control (p <0.01). MAPK and BACE1 mRNA levels of the hippocampus were significantly higher in the Hcy group (p <0.01). Different studies results indicate that; increased plasma homocysteine level was found to be a strongly independent risk factor for the progress of dementia and Alzheimer’s disease. However, there is also contradictory evidence, and it is still controversial whether HHcy is a risk factor for AD or just a bio producer. This study was carried out to determine homocystein role in Alzheimer process. According to findings It is very important to keep homocyteine level in lower grade to reduce or eliminate AD possibility.

🔖

Cite This Article

AKBULUT, D. M., VURMAZ, A. (2019). Determination of experimentally given homocysteine causes to alzheimer-like dementia in rats on the basis of different parameters. Medicine Science, Cilt: 8 - Sayı: 3, 670–676. https://ajindex.com/articles/277108

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Fargo K, Bleıler L. Alzheimer’ Association Report 2014 Alzheimer’s disease facts and figures. Alzheimers Dement. 2014;10:47-92
  2. Ferreira D, Perestelo-pérez L, Westman E, et al. Meta-review of csf core biomarkers in alzheimer’s disease: the state-of-the-art after the new revised diagnostic criteria. Front Aging Neurosci. 2014;6:47
  3. Kidd PM. Alzheimer’s disease, amnestic mild cognitive ımpairment, and age-associated memory ımpairment: current understanding and progress toward ıntegrative prevention. Altern Med Rev. 2008;13:85-115
  4. Chaı G-S, Jıang X, Feı Nı Z, et al. Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine. J Neurochem. 2013;124:388-96
  5. Brosnan JT, Brosnan ME. The sulfur-containing amino acids: an overview. J Nutr. 2006;136:1636-40
  6. Zhang Y, Zhu T, Wang L, et al. Homocysteine homeostasis and betaine-homocysteine s-methyltransferase expression in the brain of hibernating bats. PLoS ONE. 2013 8:e85632
  7. Cacciapuoti F. Lowering homocysteine levels with folic acid and B-vitamins do not reduce early atherosclerosis, but could interfere with cognitive decline and Alzheimer’s disease. J Thromb Thrombolysis. 2013;36:258–62
  8. Zhuo JM, Wang H, Praticò D. Is hyperhomocysteinemia an Alzheimer’s disease (AD) risk factor, an AD marker, or neither? Trends Pharmacol Sci. 2011;32:562-571
  9. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001;29:e45
  10. Arslan S, Ateş E, Atikcan DT, ve ark. Stres altında olan sıçanlarda ve normal koşullardaki sıçanlarda antidepresan “fluoksetin hidroklorür kullanımının öğrenme üzerine etkileri.:http://tip.baskent.edu.tr/egitim/mezuniyetoncesi/calismagrp/ogrsmpzsnm13/13.S14.pdf] erişim tarihi 2013
  11. Li MH, Tang JP, Zhang P, et al. Disturbance of endogenous hydrogen sulfide generation and endoplasmic reticulum stress in hippocampus are involved in homocysteine-induced defect in learning and memory of rats. Behav Brain Res. 2014;262:35-41
  12. Zylberstein DE, Lissner L, Björkelund C, et al. Midlife homocysteine and late-life dementia in women. A prospective population study. Neurobiol Aging. 2011;32:380-6
  13. Farkas M, Keskitalo S, Smith DE, et al. Hyperhomocysteinemia in Alzheimer’s disease: the hen and the egg? J Alzheimers Dis. 2013;33:1097-104
  14. Fuso A, Nicolia V, Ricceri L, et al. S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice. Neu