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Journals / Medicine Science / 2019 / Cilt: 8 - Sayı: 3

Investigation of biochemical and histopathological effects of tarantula cubensis D6 on lung tissue in cecal ligation and puncture-induced polymicrobial sepsis model in rats

Ayhan TANYELİ
Ersen ERASLAN
Mustafa Can GULER
Saime Ozbek SEBİN
Demet CELEBİ
Fatma Betul OZGERİS
Erdem TOKTAY
Pages
644–650
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

TCD reduces polymicrobial sepsis-induced lung injury through antioxidant, antiapoptotic, and antioxidant effects.

📌 3 Key Takeaways

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Objective & Hypothesis:To investigate the protective effect of Tarantula Cubensis D6 (TCD) on inflammation and oxidative stress in rat cecal ligation and puncture (CLP) in modified polymicrobial sepsis model.
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Key Findings & Data:Wistar albino rats were randomly divided into 4 groups: sham control group, sepsis (CLP) group, low dose TCD + CLP group, and high dose TCD + CLP group.
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Conclusion & Impact:TCD reduces polymicrobial sepsis-induced lung injury through antioxidant, antiapoptotic, and antioxidant effects.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

To investigate the protective effect of Tarantula Cubensis D6 (TCD) on inflammation and oxidative stress in rat cecal ligation and puncture (CLP) in modified polymicrobial sepsis model. Wistar albino rats were randomly divided into 4 groups: sham control group, sepsis (CLP) group, low dose TCD + CLP group, and high dose TCD + CLP group. Lung tissue samples of rats were prepared to determine levels of some cytokines related to inflammation, oxidant/antioxidant parameters apoptosis markers. In addition, lung, liver, renal, and heart tissue samples of rats were prepared to determine colony counts of E. coli. We showed that Tarantula cubensis D6 significantly reduced the increasing TNF-α, IL-1β, IL-6, TOS, OSI levels in the CLP group compared to the sham control group, and causes an increase in the decreasing TAS value and significantly reduces caspase-3 and NF-KB expressions. We determined that while E. coli colony counts increased in organs such as lung, heart, liver, and kidney in the CLP group, it was decreased in TCD groups. TCD reduces polymicrobial sepsis-induced lung injury through antioxidant, antiapoptotic, and antioxidant effects.

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Cite This Article

TANYELİ, A., ERASLAN, E., GULER, M. C., SEBİN, S. O., CELEBİ, D., OZGERİS, F. B., TOKTAY, E. (2019). Investigation of biochemical and histopathological effects of tarantula cubensis D6 on lung tissue in cecal ligation and puncture-induced polymicrobial sepsis model in rats. Medicine Science, Cilt: 8 - Sayı: 3, 644–650. https://ajindex.com/articles/277022

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