AI Summary & Key Takeaways
AI InsightThe relationship between the primary tumor location and clinicopathological features such as; gender, family history, carcinoembryonic antigen (CEA) level, metastasectomy status, the presence of a mucinous component, RAS mutation status, and overall survival (OS) were evaluated.
📌 3 Key Takeaways
Özet
Primary tumor location (PTL) is associated with very different outcomes in patients with metastatic colorectal cancer (mCRC). Clinical trials suggest that right side tumor location is an indicator of poor prognosis for patients with mCRC. The relationship between the primary tumor location and clinicopathological features such as; gender, family history, carcinoembryonic antigen (CEA) level, metastasectomy status, the presence of a mucinous component, RAS mutation status, and overall survival (OS) were evaluated. A total of 253 patients (203 left-sided, 50 right-sided) were included in the study. Median OS time for patients with metastatic right sided colon tumors were 19 (15.2-22.7) months, and OS for left sided colon tumors were 35 (29.5-40.4) months. The left-sided colon group’s OS time was significantly higher than the right-sided colon group (p ,1 panRAS mutant, CEA level ≥5 ng/mL and non-metastasectomy. The difference between these two groups were significantly associated with an improved OS (p <0.001). Our study suggests that tumor location is an essential prognostic factor in patients with mCRC to be independent of other prognostic factors. OS was significantly longer in the patients with left-sided mCRC than right-sided.