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Journals / Medicine Science / 2019 / Cilt: 8 - Sayı: 2

Effect of benidipine on experimental gastric ulcers in rats

Bahadir SULEYMAN
Renad MAMMADOV
Adalet OZCİCEK
Fatih OZCİCEK
Durdu ALTUNER
MEHMET KUZUCU
Zeynep SULEYMAN
Pages
296–300
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Benidipine may be useful in preventing the toxic effect of indomethacin on the stomach.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Peptic ulcer has been reported to increase acid secretion and lead to oxidative stress.
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Key Findings & Data:These groups were treated with famotidine, benidipine and distilled water respectively 5 minutes before indomethacin administration.
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Conclusion & Impact:Benidipine may be useful in preventing the toxic effect of indomethacin on the stomach.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Peptic ulcer has been reported to increase acid secretion and lead to oxidative stress. Benidipine is an antihypertensive drug with antioxidant properties. This study aims to investigate the effects of benidipine on indomethacin-induced gastric ulcers in rats. Four groups were designed in this study. Gastric ulcer was occurred with indomethacin in the first three groups. These groups were treated with famotidine, benidipine and distilled water respectively 5 minutes before indomethacin administration. The fourth group rats didn’t have gastric ulcer and they received only distilled water. Six hours after drug administration gastric tissue was extracted and macroscopic and biochemical examinations were performed. Damaged areas in the stomach of benidipine and famotidine receiving animal groups were smaller than the indomethacin received animals. Indomethacin elevated the levels of malondialdehyde and myeloperoxidase in the stomach tissue (p<0.0001), and also decreased glutathione, glutathione related enzymes and superoxide dismutase (p<0.0001). Benidipine may be useful in preventing the toxic effect of indomethacin on the stomach.

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Cite This Article

SULEYMAN, B., MAMMADOV, R., OZCİCEK, A., OZCİCEK, F., ALTUNER, D., KUZUCU, M., SULEYMAN, Z. (2019). Effect of benidipine on experimental gastric ulcers in rats. Medicine Science, Cilt: 8 - Sayı: 2, 296–300. https://ajindex.com/articles/276944

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References (10)

  1. Chan FK, Leung WK. Peptic-ulcer disease. Lancet. 2002;360:933-41. Schwartz K. Beitrage űber penetrierende Magen und Jejunalgeschwűre. Klin Chir. 1910;57:96-128.
  2. Sokic MA, Krstic M, Popovic D, et al. Role of Helicobacter pylori infection and use of NSAIDs in the etiopathogenesis of upper gastrointestinal bleeding. Acta Chir Iugosl. 2007;54:51-62.
  3. Szabo S, Trier J, Brown A, et al. Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology. 1985;88:228-36.
  4. Aadland E, Berstad A. Effect of verapamil on gastric secretion in man. Scand J Gastroenterol. 1983;18:969-71. Kato T. Role of mitochondrial DNA in calcium signaling abnormality in bipolar disorder. Cell Calcium. 2008;44:92-102.
  5. Zavodnik IB, Dremza IK, Cheshchevik VT, et al. Oxidative damage of rat liver mitochondria during exposure to t-butyl hydroperoxide. Role of Ca2+ ions in oxidative processes. Life Sci. 2013;92:1110-7.
  6. Itoh M, Guth PH. Role of oxygen-derived free radicals in hemorrhagic shockinduced gastric lesions in the rat. Gastroenterology. 1985;88:1162-7. Salim A. Scavenging free radicals to prevent stress-induced gastric mucosal injury. Lancet. 1989;334:1390. Naito Y, Yoshikawa T, Yoshida N, et al. Role of oxygen radical and lipid peroxidation in indomethacin-induced gastric mucosal injury. Dig Diss Sci. 1998;43:30-4.
  7. Sigthorsson G, Crane R, Simon T, et al. COX-2 inhibition with rofecoxib does not increase intestinal permeability in healthy subjects: a double blind crossover study comparing rofecoxib with placebo and indomethacin. Gut. 2000;47:527-32.
  8. Suleyman H, Albayrak A, Bilici M, et al. Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers. Inflammation. 2010;33:224-34.
  9. Suleyman H, Demircan B, Karagoz Y. Anti-inflammatory and side effects of cyclo-oxygenase inhibitors. Pharmacol Rep. 2007;59:247. Piao X, Li S, Sui X, et al. 1-deoxynojirimycin (DNJ) ameliorates indomethacin-induced gastric ulcer in mice by affecting NF-kappaB signaling pathway. Front Pharmacol. 2018;9:372. Albayrak A, Alp HH, Suleyman H. Investigation of antiulcer and antioxidant activity of moclobemide in rats. Eurasian J Med. 2015;47:32. Polat B, Suleyman H, Alp HH. Adaptation of rat gastric tissue against indomethacin toxicity. Chem Biol Interact. 2010;186:82-9.
  10. Saito I, Suzuki H, Kageyama S, et al. Effect of antihypertensive treatment on cardiovascular events in elderly hypertensive patients: Japan’s Benidipine Resear