On the other hand, according to the activity using linear incision wound model as well as hydroxyproline content of the treated tissue, all three extracts did not indicate wound healing activity.
📌 3 Key Takeaways
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Objective & Hypothesis:Since Cucurbita pepo L. seeds have been reported to have beneficial effects in folk medicine for many years, in this study, in vivo wound healing activities of diethyl ether, chloroform and ethyl acetate extracts prepared from C. pepo seeds were evaluated by linear incision wound model, and hydroxyproline content.
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Key Findings & Data:The ethyl acetate extract had the highest inhibitory effect on acetic acid-induced capillary permeability, but the rest of the extracts didn’t display significant anti-inflammatory activity.
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Conclusion & Impact:On the other hand, according to the activity using linear incision wound model as well as hydroxyproline content of the treated tissue, all three extracts did not indicate wound healing activity.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Özet
Since Cucurbita pepo L. seeds have been reported to have beneficial effects in folk medicine for many years, in this study, in vivo wound healing activities of diethyl ether, chloroform and ethyl acetate extracts prepared from C. pepo seeds were evaluated by linear incision wound model, and hydroxyproline content. Furthermore, the extracts were screened for anti-inflammatory activity based on the inhibition of acetic acid-induced capillary permeability. The ethyl acetate extract had the highest inhibitory effect on acetic acid-induced capillary permeability, but the rest of the extracts didn’t display significant anti-inflammatory activity. On the other hand, according to the activity using linear incision wound model as well as hydroxyproline content of the treated tissue, all three extracts did not indicate wound healing activity.
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Cite This Article
KAHRAMAN, Ç., ZARE, G., ARABACI, S., AKKOL, E. K., ÇANKAYA, İ. (2020). Evaluation of Cucurbita pepo L. seeds used in folk medicine for their anti-inflammatory and wound healing activity. Medicine Science, Cilt: 9 - Sayı: 2, 381–384. https://ajindex.com/articles/276831
Ratnam N, Vandana, Najibullah M, Ibrahim M. A review on Cucurbita pepo. Int J Pharmacognosy Phytochem Res. 2017;9:1190-4
Omotayo FO, Borokini TI. Comparative phytochemical and ethnomedicinal survey of selected medicinal plants in Nigeria. Scientific Res Essay. 2012;7:989-99
Gutierrez RMP. Review of Cucurbita pepo (Pumpkin) its phytochemistry and pharmacology. Med Chem. 2016;6:12-21
Rahman AHM. Ethno-medico-botanical investigation on cucurbits of the Rajshahi Division, Bangladesh. J Med Plants Stud. 2013;1:118-25. 5. Đorđević I, Milutinović M, Kostic M, et al. Phytotherapeutic approach to benign prostatic hyperplasia treatment by pumpkin seed (Cucurbita pepo L, Cucurbitaceae). Acta Medica Medianae. 2016;55:76-84
PDR (Physician’s Desk Reference) for Herbal Medicines 3rd Edition. Thomson, 2004. p. 663-5
Caili F, Huan S, Quanhong L. A Review on pharmacological activities and utilization technologies of pumpkin. Plant Foods for Hum Nutr. 2006;61:70- 7
Yadav M, Jain S, Tomar R. Medicinal and biological potential of pumpkin: an updated review. Nutr Res Rev. 2010;23:184-90
Adnan M, Gul S, Batool S, et al. A review on the ethnobotany, phytochemistry, pharmacology and nutritional composition of Cucurbita pepo L. J Phytopharmacol. 2017;6:133-9
Sener B, Erdogan Orhan I, Ozcelik B, et al. Antimicrobial and antiviral activities of 2 seed oil samples of Cucurbita pepo L. and their fatty acid analysis. Nat Prod Commun. 2007;2:395-8
Kulczyński B, Gramza Michalowska A. The profile of secondary metabolites and other bioactive compounds in Cucurbita pepo L. and Cucurbita moschata pumpkin cultivars. Molecules. 2019;24:2945
Murkovic M, Hillebrand A, Winkler J, et al. Variability of fatty acid content in pumpkin seeds (Cucurbita pepo L.). Z Lebensm Unters Forsch. 1996;203:216-9
Lodhi S, Pawar RS, Jain AP, et al. Wound healing potential of Tephrosia purpurea (Linn.) Pers. in rats. J Ethnopharmacol. 2006;108:204-10
Suguna L, Singh S, Sivakumar P, et al. Influence of terminalia chebula on dermal wound healing in rats. Phytother Res. 2002;16:227-31
Degim Z, Celebi N, Sayan H, et al. An investigation on skin wound healing in mice with a taurine-chitosan gel formulation. Amino Acids. 2002;22:187-98
Whittle BA. The use of changes in capillary permeability in mice to distinguish between narcotic and nonnarcotic analgesics. Br J Pharmacol Chemother. 1964;22:246-53
Yesilada E, Kupeli E. Clematis vitalba L. aerial part