Journals / Medicine Science / 2020 / Cilt: 9 - Sayı: 2

Serum elabela levels in women with tubal ectopic pregnancy: A case-control study

Pages
289–292
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Since placenta is the primary source of elabela, this lack of difference might be due to the insufficient placental as well as fetal development in fallopian tubes.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Elabela, a circulating peptide hormone derived from the placenta, plays a crucial role in embryonic development and function of the human placenta during pregnancy.
📊
Key Findings & Data:Thirty women with tubal ectopic pregnancy constituted Group 1 and 30 women with healthy pregnancy served as controls (Group 2).
💡
Conclusion & Impact:Since placenta is the primary source of elabela, this lack of difference might be due to the insufficient placental as well as fetal development in fallopian tubes.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Elabela, a circulating peptide hormone derived from the placenta, plays a crucial role in embryonic development and function of the human placenta during pregnancy. We aimed to investigate serum elabela levels in ectopic pregnancy. Sixty cases admitted to Emergency Department and Obstetrics and Gynecology Clinic were included in this case-control study. Thirty women with tubal ectopic pregnancy constituted Group 1 and 30 women with healthy pregnancy served as controls (Group 2). Blood samples were collected from all participants. Demographic and obstetric characteristics of the whole study cohort were also recorded. Levels of serum elabela were measured in each group by enzyme-linked immunosorbent assay . Age, gender, gestational age, obstetrics history, and body mass index of the groups were similar. Mean serum elabela levels were 7.52 ± 1.1 ng/mL and 7.05 ± 1.2 ng/mL in group 1 and group 2, respectively. There was no statistically significant difference between the two groups with respect to serum elabela levels (t=1.581, p=0.119). In the present study, serum elabela levels were not significantly different in women with ectopic pregnancies than healthy pregnancies. Since placenta is the primary source of elabela, this lack of difference might be due to the insufficient placental as well as fetal development in fallopian tubes.

🔖

Cite This Article

GÜL, E., DENİZ, R., KAVAK, E. Ç., ŞANLI, C., BATMAZ, İ., BULU, G., KAVAK, S. B., BAYKUŞ, Y. (2020). Serum elabela levels in women with tubal ectopic pregnancy: A case-control study. Medicine Science, Cilt: 9 - Sayı: 2, 289–292. https://ajindex.com/articles/276786

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (17)

  1. Barnhart KT. Clinical practice. Ectopic pregnancy. N Engl J Med. 2009;361:379-87
  2. Murray H, Baakdah H, Bardell T, Tulandi T. Diagnosis and treatment of ectopic pregnancy. CMAJ. 2005;173:905-12
  3. Carusi D. Pregnancy of unknown location: Evaluation and management. Semin Perinatol. 2019;43:95-100
  4. Turkmen GG, Karcaaltincaba D, Isik H, et al. Does adenosine deaminase activity play a role in the early diagnosis of ectopic pregnancy? J Obstet Gynaecol. 2016;36:347-50
  5. Dhombres F, Maurice P, Guilbaud L, et al. A Novel Intelligent Scan Assistant System for Early Pregnancy Diagnosis by Ultrasound: Clinical Decision Support System Evaluation Study. J Med Internet Res. 2019;21:e14286
  6. Kontomanolis EN, Kalagasidou S, Fasoulakis Z. MicroRNAs as Potential Serum Biomarkers for Early Detection of Ectopic Pregnancy. Cureus. 2018;10:e2344
  7. Zhang Y, Wang Y, Lou Y, et al. Elabela, a newly discovered APJ ligand: Similarities and differences with Apelin. Peptides. 2018;109:23-32
  8. Wang Z, Yu D, Wang M, et al. Elabela-apelin receptor signaling pathway is functional in mammalian systems. Sci Rep. 2015;5:8170
  9. Xu J, Chen L, Jiang Z, Li L. Biological functions of Elabela, a novel endogenous ligand of APJ receptor. J Cell Physiol. 2018;233:6472-82
  10. Liu Y, Wang L, Shi H. The biological function of ELABELA and APJ signaling in the cardiovascular system and pre-eclampsia. Hypertens Res. 2019;42:928-34
  11. Zhou Q, Zhang K, Guo Y, et al. Elabela-APJ axis contributes to embryonic development and prevents pre-eclampsia in pregnancy. Acta Biochim Biophys Sin (Shanghai). 2018;50:319-21
  12. Ho L, van Dijk M, Chye STJ, et al. ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice. Science. 2017;357:707-13
  13. Panaitescu B, Romero R, Gomez-Lopez N, et al. ELABELA plasma concentrations are increased in women with late-onset preeclampsia. J Matern Fetal Neonatal Med. 2018:1-11
  14. Pritchard N, Kaitu’u-Lino TJ, Gong S, et al. ELABELA/APELA Levels Are Not Decreased in the Maternal Circulation or Placenta among Women with Preeclampsia. Am J Pathol. 2018;188:1749-53
  15. Zhou L, Sun H, Cheng R, et al. ELABELA, as a potential diagnostic biomarker of preeclampsia, regulates abnormally shallow placentation via APJ. Am J Physiol Endocrinol Metab. 2019;316:E773-E81
  16. Georgiadou D, Afink GB, van Dijk M. The apelinergic-axis in human preeclamptic pregnancies: A systematic review. Pregnancy Hypertens. 2019;17:148-57
  17. Faul F, Erdfelder E, Lang