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Journals / Medicine Science / 2021 / Cilt: 10 - Sayı: 1

Investigation of antiphospholipid antibody syndrome markers in the etiology of recurrent miscarriage

Vildan GÖRGÜLÜ
Orhan Cem AKTEPE
Birol ŞAFAK
Pages
184–190
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Among the subgroups of these antibodies, ACA and anti-annexin V can serve as highly appropriate diagnostic markers in recurrent miscarriage.

📌 3 Key Takeaways

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Objective & Hypothesis:This study aimed to determine the markers of antiphospholipid antibody syndrome (APS), which has an important place in the etiology of recurrent miscarriage, and to provide guidance for the treatment of the related disorders.
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Key Findings & Data:This prospective observational study was performed on 120 female patients admitted to the Obstetrics and Gynecology outpatient clinics due to recurrent pregnancy loss.
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Conclusion & Impact:Among the subgroups of these antibodies, ACA and anti-annexin V can serve as highly appropriate diagnostic markers in recurrent miscarriage.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

This study aimed to determine the markers of antiphospholipid antibody syndrome (APS), which has an important place in the etiology of recurrent miscarriage, and to provide guidance for the treatment of the related disorders. This prospective observational study was performed on 120 female patients admitted to the Obstetrics and Gynecology outpatient clinics due to recurrent pregnancy loss. Blood samples were analyzed using the Enzyme-Linked Immunosorbent Assay (ELISA) technique to find out the levels of APS-associated anticardiolipin (ACA), anti-beta2-glycoprotein I (aβ2GPI), anti-annexin V (aANXV), anti-prothrombin (aPT), and antiphosphatidylserine (aPS) antibodies. A statistically significant difference was found between increased age groups and the number of miscarriages (p=0.03, p<0.05). There were no significant differences between the age groups by the time of miscarriage (p=0.35, p<0.05). ACA positivity (75%, n = 90) and anti-annexin V positivity (50.8%, n = 61) were higher than the positive results found in other tests(p=0.01, p<0.05). Antiphospholipid antibodies (APAs) showed significantly different positivity levels by the age groups (p=0.01, p<0.05). The positivity levels of APAs were significantly different by the number of miscarriages (p=0.01, p<0.05). Other antibody levels were not statistically significantly different. The frequency of positive APA levels increases with advancing age and a high number of miscarriages in association with the etiology of recurrent miscarriage. Among the subgroups of these antibodies, ACA and anti-annexin V can serve as highly appropriate diagnostic markers in recurrent miscarriage.

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Cite This Article

GÖRGÜLÜ, V., AKTEPE, O. C., ŞAFAK, B. (2021). Investigation of antiphospholipid antibody syndrome markers in the etiology of recurrent miscarriage. Medicine Science, Cilt: 10 - Sayı: 1, 184–190. https://ajindex.com/articles/276741

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