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Journals / Medical Network Klinik Bilimler ve Doktor / 2004 / Cilt: 10 - Sayı: 4

Endodermal sinus tumors

Overin endodermal sinüs tümörleri

Yeşilkaya Gülizar ERSOY
Cüneyt Eftal TANER
Fatma ALTINTAŞOĞLU
Afet EGE
Sevil SAYLAN
Pages
463–466
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: As a conclusion, EST are important because of encountering at young ages and with a good response to chemoterapy.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To evaluate the clinical features, treatment and prognosis of ovarian endodermal sinus tumors (EST).
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Key Findings & Data:Material and Methods: 9 cases histopathologically diagnosed as EST were analysed retrospectively.
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Conclusion & Impact:Conclusion: As a conclusion, EST are important because of encountering at young ages and with a good response to chemoterapy.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Neoplazmlar · germ hücreli ve embriyonel · Yumurtalık

Abstract

Objective: To evaluate the clinical features, treatment and prognosis of ovarian endodermal sinus tumors (EST). Material and Methods: 9 cases histopathologically diagnosed as EST were analysed retrospectively. Results: The mean age was 24.6 years. All cases were nulliparous except one. The most common complaint of the patients were abdominal pain and distantion. At USG examination, there was unilateral adnexial mass with a mean diameter of 15 cm (8-20 cm.). Preoperative AFP levels were higher than normal in 4 cases (44.4%).Primary choice of treatment was surgery for all cases. Operation subtypes included TAH+BSO+ommentectomy+ appendectomy+lymph node sampling in 3 cases, USO+wedge resection from other ovary+ommentectomy+ appendectomy+lymph node sampling for the rest 6 cases. After medical oncological consultations, adjuvant chemoterapy (VAC %55.5 or BEP %22.2) were administered for all cases. The mean follow up time was 70.5 months. A 52 years old case with stage IIIC disease had metastazis at ceacum at 5 months after diagnosis and died after 7 months. Conclusion: As a conclusion, EST are important because of encountering at young ages and with a good response to chemoterapy.

Özet

Amaç: Ovaryal endodermal sinüs tümörlü (EST) olgularınının klinik özellikleri, tedavi ve prognozlarının incelenmesi. Gereç ve Yöntem: Histopatolojik olarak EST tanısı almış 9 olgu retrospektif olarak analiz edildi. Bulgular: Olgular ortalama 24.6 yaşında olup bir olgu dışında hepsi nullipardı. Olguların en sık görülen yakınması karın ağrısı ve karın şişliği idi. Ultrasonografik incelemede ortalama tümör çapı 15 cm. olan (8 cm ile 20 cm arası) ünilateral adnexial kitle tespit edilmişti. Preoperatif olarak AFP ölçümü yapılan 9 olgunun 4'ünde (%44.4) değerler normalden yüksekti. Olguların tümünde primer tedavi cerrrahiydi. 3 olguya (%33.3) TAH+BSO+Omentektomi+ appendektomi+lenf örneklemesi uygulandı. Diğer 6 olguya unilateral ooferektomi diğer overden wedge rezeksiyon, appendektomi, omentektomi ve lenf örneklemesi yapıldı. Olguların tümüne medikal onkoloji konsültasyonları yapılarak adjuvan kemoterapi olarak VAC (5/9 %55.5) veya BEP (2/9 %22.2) kombinasyon terapisi uygulandı. Olguların ortalama takip süresi 70.5 aydı. Evre IIIC olan 52 yaşında olan bir olguda tanıdan 5 ay sonra çekumda metastaz saptanmış ve 7 ay sonra ex olmuştur. Diğer olguların takipleri devam etmektedir. Sonuç: Sonuç olarak overin germ hücreli tümörleri içinde EST genç yaşta görülmesine karşın kemoterapiye iyi cevap vermesi nedeniyle önemlidir.

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Cite This Article

ERSOY, Y. G., TANER, C. E., ALTINTAŞOĞLU, F., EGE, A., SAYLAN, S. (2004). Endodermal sinus tumors. Medical Network Klinik Bilimler ve Doktor, Cilt: 10 - Sayı: 4, 463–466. https://ajindex.com/articles/273129

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