AI Summary & Key Takeaways
AI InsightSolutionfocused studies are required for developing implants with better biocompatibility, lower infection rates, and lower costs in the following years.
📌 3 Key Takeaways
Özet
Objective: Instrumentation is used for treating spinal fractures. Degenerative and neoplastic spine diseases have gradually increased in recent years because of advancements in spine surgery. The major disadvantage of instrumentation is implant-associated infections that result in morbidity and mortality, in addition to considerable financial losses because of increased treatment costs. This study examined the effectiveness of Ti alloy screws coated with Silver (Ag) ion nanoparticles in preventing infection in the rat spine. Materials and Methods: In this study, 24 male, six-month-old white Sprague-Dawley rats were used. The animals were divided into three groups, each with an equal number of animals. A pedicle screw of appropriate size was placed in the lumbar vertebrae of animals and inoculated with a 1 million CFU/10 microliter Staphylococcus Aureus ATCC 29213 strain. A Ti alloy microscrew with a surface area of 25 mm2 was placed in the first group, Ag-coated Ti alloy microscrew with a surface area of 25 mm2 was placed in the second group, and a Ag-coated Ti alloy microscrew with a surface area of 50 mm2 was placed in the third group. Results: Screw and tissue samples were taken and microbiologically examined. After microbiological evaluation, no statistically significant difference was reported between these groups in terms of the number of microorganisms growing on the screw and tissue. Conclusion: Because of the difficulties and financial burdens that arise after the occurrence of an infection, the importance and necessity of developing anti-infective biomaterials are very clear. No anti-infective effect was observed in the Ag-coated pedicle screws in our study. Solutionfocused studies are required for developing implants with better biocompatibility, lower infection rates, and lower costs in the following years.