AI Summary & Key Takeaways
AI InsightConclusions: There is a consistency between histolopathologic diagnosis of renal biopsies and clinical findings in our study.
📌 3 Key Takeaways
Abstract
Aim: To determine the prevalence of renal diseases that were diagnosed by renal biopsy and to analyze the relationship be- tween clinical symptoms and histopathological diagnosis. Material and Method: A total of 607 cases diagnosed by renal biopsy between February 2005 and February 2012 were eva- luated retrospectively in the study. Findings: Two hundred sixty-five patients were female,342 male,average age was 41(15-81).The most frequent clinical syn- dromes were nephrotic syndrome (45.3%), nephritic syndrome (18.1%), nephrotic and nephritic syndrome (19.1%), rapidly progressive glomerulonephritis (2.9%), acute renal failure (4.1%),chronic renal failure (8%) and asymptomatic urine abnor- malities (2.3%). Primary and secondary glomerulonephritis were the most frequent diseases amongst the others. The fre- quency of subtypes of primary glomerulonephritis groups were membranous glomerulonephritis, IgA nephritis, focal seg- mental glomerulosclerosis, minimal lesion disease, membranoproliferative glomerulonephritis with the percentages of(29.3%), (28.9%), (15.7%), (9.3%), (17.6%) respectively. Meanwhile the subtypes of secondary forms were amyloidosis, crescentic glomerulonephritis, lupus nephritis, diabetic nephropathy with the percentages of (40.2%), (24.5%), (16.7%), (9.4%) respectively. Membranous glomerulonephritis, (26.9%), amyloidosis (16.7%) and focal segmental glomerulosclerosis (12.3%) were the most reasons of nephrotic syndrome and IgA nephropathy (42.7%), lupus nephritis (10.9%) and mem- branoproliferative glomerulonephritis (7.2%) were the most frequent reasons for nephritic syndrome. Conclusions: There is a consistency between histolopathologic diagnosis of renal biopsies and clinical findings in our study.
Özet
Amaç: Merkezimizde histopatolojik inceleme ile tanı alan renal hastalıkların sıklığını belirlemek ve klinik semptomlarla his- topatolojik tanıların ilişkisini incelemektir. Gereç ve Yöntem: Çalışmada Şubat 2005 – Şubat 2012 tarihleri arasında Patoloji Laboratuvarında tanı konmuş 607 olgu geriye dönük incelenmiştir. Bulgular: Olguların 265’i kadın, 342’si erkek olup, yaş ortalaması 41(15-81)dir. En sık klinik sendromlar nefrotik sendrom (%45.3), nefritik sendrom (%18.1), nefrotik+nefritik sendrom (%19.1), Hızlı İler- leyen Glomerülonefrit (%2.9), Akut böbrek yetmezliği (%4.1), Kronik Böbrek Yetmezliği (%8) ve asemptomatik idrar anor- mallikleri (%2.3)dir. Primer (%48.7) ve sekonder (%32.7) glomerülonefritler diğerlerine göre en sık rastlanan hastalık grup- larıdır. Primer glomerülonefrit grubunda subtiplerin sıklığı Membranöz Glomerülonefrit (%29.3), IgA Nefropatisi (%28.9), Fokal Segmental Glomerüloskleroz (%15.7), Minimal Lezyon Hastalığı (%9.3), Membranoproliferatif Glomerülonefrit (%17.6) iken sekonder formlarda görülenler Amiloidoz (%40.2), Kresentik Glomerülonefrit (%24.5), Lupus Nefriti (%16.7), DiabetikNefropati (%9.4) şeklinde idi. Membranöz glomerülonefrit (%26.9), Amiloidoz (%16.7) ve Fokal Segmental Glomerüloskleroz (%12.3) en sık karşılaşılan nefrotik sendrom nedenleri iken, IgANefropatisi (%42.7), Lupus Nefriti (%10.9) ve Membranoproliferatif Glomerülonefrit (%7.2) en sık nefritik sendrom nedenleri olarak bulunmuştur. Sonuç: Çalışmamızda renal biyopsilerin histopatolojik tanıları ile klinik bulguları arasında uyumluluk saptanmıştır.