Journals / Haseki Tıp Bülteni / 2002 / Cilt: 40 - Sayı: 4

(PLASMA HOMOCYSTEINE LEVES IN CORONARY HEART DISEASE)

Koroner arter hastalığında plazma homosistein düzeyleri

Pages
313–315
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusîcn, plasma homosistein levels is a independent risk factor for atherosclerosis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Many patients with myocardial infraction have none of the conventional risk factors for coronary artery disease, including hypertension, smoking, diabetes mellitus, hyperkolesterolemia and a family history of the dissease.
📊
Key Findings & Data:Eigth patient (45%) has a elevated blood homosistein level but non of control group was found an elevated homosistein levels.
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Conclusion & Impact:In conclusîcn, plasma homosistein levels is a independent risk factor for atherosclerosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Many patients with myocardial infraction have none of the conventional risk factors for coronary artery disease, including hypertension, smoking, diabetes mellitus, hyperkolesterolemia and a family history of the dissease. An elevated plasma homocysteine concentration has recently been identified as an independent risk factor for atherosclerosis and thrombosis. We investigated plasma homosistein levels patients with acute myocardial infarction (AMI). Twenty patient with AMI and thirteen healty control with no kown conventior.al risk factors was enrolled to study. Eigth patient (45%) has a elevated blood homosistein level but non of control group was found an elevated homosistein levels. In conclusîcn, plasma homosistein levels is a independent risk factor for atherosclerosis.

Özet

Miyokard infarktüsü olan hastalann birçoğunda sigara içimi, hipertansiyon, diyabe-tes mellitus, obesite ve hiperkolesterolemi gibi iyi bilinen risk faktörlerinden hiçbiri tespit edilememektedir d). Son yıllarda herhangi bir risk faktörü tespit edilemeyen aterosk-lerozlu hastalarda, hiperhomosisteinemi bağımsız bir risk faktörü olduğu yapılan sayısız çalışmayla ortaya konmuştur. Bizde çalışmamızda genç, akut miyokard infarktüsü geçirmiş hastalarda plazma homosistein düzeylerini araştırdık. Çalışma akut miyokard in-fartüslü 20 hasta ve 13 sağlam kontrol alnarak yapıldı. Bilinen herhangibir ateroskleroz risk faktörü taşıyan hastalar çalışma dışı bırakıldı. Ortalama homosistein düzeyleri hasta grubunda 16.755pmol/l (en düşük 7,5 pmol/1, en yüksek 34 pmol/1) kontrol grubunda 8.469pmol/l (6.3]ümol/l en düşük, en yüksek 14.5pmol/l) idi (p<0.05). Hasta ve kontrol grubunda plazma kolesterol, LDL ve HDL kolesterol düzeyleri ve BMI'i normal sınırlardaydı. Sonuç olarak, bizim çalışmamızda hiperhomosisteinemi koroner arter hastalığının etyolojisinde bağımsız bir risk faktörü olarak düşünülebilir.

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Cite This Article

ÖZDİL, K., ATAOĞLU, E., YENİGÜN, M., AYER, M., ŞAR, F., TEMİZ, L. (2002). (PLASMA HOMOCYSTEINE LEVES IN CORONARY HEART DISEASE). Haseki Tıp Bülteni, Cilt: 40 - Sayı: 4, 313–315. https://ajindex.com/articles/268266

References (3)

  1. Thompson Git, Wilson PW: Koroner risîc faktörleri. 1995.
  2. Science Press,
  3. Turgut Yayıncılık, İstanbul 2.Boushey C, B&resford SAA, Omenn GS, Motulsky AG: A quantitative assessment of homocysteine as a risk factor for vascular disease. JAMA. 1995; 274: 1049-1057 3.McCully KS: Vascular pathology ofl'omoCJMeinemîa: Implications for the pathogenesis ofarteriosclerosis. Am J Pathol 1969; 56:111 4.Graham IM, Daly LE, Refsum HM et all: Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. JAMAA991-, jun 11; 1775-1781 5.Welch NG, Upchurch RG and Lascalzo J: Homocysteine, oxidative stress, annd vascular disease. Hospital practice 1997;32(6): 81-92 6.Wilcken DEL, Wilcken B: The pathogenesis of coronary artery disease. A possible role for methionine methabo-lism. J Clin Invest. 1976;57:211-215 7.Boers GHJ, Smals AGH, Trijbels JMF et all: Heterozygosity for homocystinuria in premature peripheral and cerebral occlusive arterial disease. N Eng J Med. 1985;313: 709-715 8.Boers GHJ: Hyperhomocyteinemia: a newly recognized risk factor for vascular disease. Neth J Med. 1994; 45: 34-41 9.Ueland Pm, Refsum H, Brattstrom L: Plasma homocysteine and cardiovascular disease. In: Francis RB Jr (eds) Atherosclerotic cardiovascular disease, hemostasis, and endothelial function. New York: Marcel Dekker, 1992; 183-236 10.Boushey CJ, Beresford SAA, Omenn GS, Motulsky AG: A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. JAMA. 1995; 274: 1049-1057