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Journals / Haseki Tıp Bülteni / 2012 / Cilt: 50 - Sayı: 2

Thyroid autoimmunity and gluten-sensitive enteropathy in children with type 1 diabetes mellitus

Tip 1 diyabetes mellituslu çocuklarda tiroid otoimmünitesi ve gluten duyarlı enteropati

Gafur DOĞDU
Nilgün SELÇUK DURU
Murat ELEVLİ
Mahmut ÇİVİLİBAL
Pages
39–42
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Thus, the most rapid and meaningful method is to investigate the presence of autoantibodies using serological tests. (The Medical Bulletin of Haseki 2012; 50: 39-42)

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: To determine the seroprevalence of autoimmune thyroiditis and gluten-sensitive enteropathy (GSE) in patients with type 1 diabetes mellitus (T1DM) and to emphasize the importance of early diagnosis.
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Key Findings & Data:Patients and Methods: Fifty-five children and adolescents (age ranged 3-18 years) with T1DM were included in the study.
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Conclusion & Impact:Thus, the most rapid and meaningful method is to investigate the presence of autoantibodies using serological tests. (The Medical Bulletin of Haseki 2012; 50: 39-42)
🔬Design:Research Article
📍Scope:2012 Verileri
⚙️Variables:Domain Parameters

Abstract

Introduction: To determine the seroprevalence of autoimmune thyroiditis and gluten-sensitive enteropathy (GSE) in patients with type 1 diabetes mellitus (T1DM) and to emphasize the importance of early diagnosis. Patients and Methods: Fifty-five children and adolescents (age ranged 3-18 years) with T1DM were included in the study. Hemoglobin A1c (HbA1c), free T3 (fT3), free T4 (fT4), thyroid stimulating hormone (TSH), anti-tiroglobulin (anti-TG), anti-thyroid peroxidase (anti-TPO), anti-gliadin IgA and IgG, and anti-endomisyum IgA antibody (anti- EMA) were investigated. Results: Eight of our cases (14.5%) were positive for anti-TPO, 9/55 (16.3%) for anti-TG, 8/55 (14.5%) for anti-EMA, 8/55 (14.5%) for anti-gliadin IgA, and 5/55 (9.0%) for anti-gliadin IgG. None of these antibodies were detected in healthy controls. In eight patients, who had positive anti-TPO and anti-TG, thyroid ultrasound results confirmed thyroiditis. Anti-EMA and anti-gliadin IgA were positive in five patients. Four of them were diagnosed with GSE. Conclusion: In patients with T1DM, the seroprevalences of autoimmune thyroiditis and GSE were higher than that in healthy controls. Therefore, regardless of the symptoms of patients, autoimmune thyroiditis and GSE should be investigated in all patients with T1DM. Thus, the most rapid and meaningful method is to investigate the presence of autoantibodies using serological tests. (The Medical Bulletin of Haseki 2012; 50: 39-42)

Özet

Giriş: Tip 1 diyabet tanılı hastalarda otoimmün tiroidit ve gluten duyarlı enteropati (GDE) sıklığını saptayarak bu hastalarda erken tanının önemini vurgulamaktır. Hastalar ve Yöntem: Çalışmaya tip 1 diyabet tanılı 3-18 yaş arasındaki 55 çocuk ve ergen hasta alındı. HbA1c, serbest T3 (sT3), serbest T4 (sT4), tiroid stimülan hormon (TSH), anti-tiroglobulin (anti-TG), anti-tiroid peroksidaz (anti-TPO), anti-gliadin IgA ve IgG ve anti-endomisyum IgA antikoru (anti-EMA) çalışıldı Bulgular: Elli beş olgunun 8’inde (%14.5) anti-TPO, 9’unda (%16.3) anti-TG, 8’inde (%14.5) anti-EMA, 8’inde (%14.5) anti-gliadin IgA ve 5’inde (%9.0) anti-gliadin IgG pozitif bulundu. Kontrol grubunda ise antikor pozitifliğine rastlanılmadı. Hem anti-TPO hem de anti-TG pozitifliği saptanan bütün hastaların tiroid ultrasonografileri otoimmün tiroidit ile uyumlu bulundu. Beş hastada ise hem anti-EMA hem de anti-gliadin IgA ve IgG pozitifliği saptandı. Bu 5 hastanın dördü (1 kız, 3 erkek) GDE tanısı aldı. Sonuç: Tip 1 diyabet hastalarında otoimmün tiroidit ve GDE sıklığının sağlıklı çocuklara göre daha fazla olduğu belirlendi. Bu nedenle, Tip 1 diyabetli tüm hastalarda semptomlarına bakılmaksızın otoimmün tiroidit ve GDE’nin araştırılması gerekmektedir. Bunun için, en hızlı ve anlamlı yol serolojik testler yardımı ile otoantikorların taranmasıdır.

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Cite This Article

DOĞDU, G., DURU, N. S., ELEVLİ, M., ÇİVİLİBAL, M. (2012). Thyroid autoimmunity and gluten-sensitive enteropathy in children with type 1 diabetes mellitus. Haseki Tıp Bülteni, Cilt: 50 - Sayı: 2, 39–42. https://ajindex.com/articles/267964

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