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Journals / Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi / 2020 / Cilt: 10 - Sayı: 1

Preparation, Characterization, and Antioxidant Features of Some New Schiff Bases Derived from Isatins and Hydrazine

Hidrazin ve Isatinlerden Elde Edilen Bazı Yeni Schiff Bazlarının Sentezi, Karakterizasyonu ve Antioksidan Özellikleri

Halit MUĞLU
Hasan YAKAN
Pages
439–447
Publication Date
2020-03-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results were given with calculated IC50 values.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:New isatins based on Schiff bases were prepared from hydrazine, 5-substituted isatins, and aldehydes under reflux in ethanol.
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Key Findings & Data:The structures of the synthesized compounds were elucidated by using IR, 13C NMR, 1H NMR spectroscopy and elemental analysis.
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Conclusion & Impact:The results were given with calculated IC50 values.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Schiff baz · isatin · antioxidant özellikler

Abstract

New isatins based on Schiff bases were prepared from hydrazine, 5-substituted isatins, and aldehydes under reflux in ethanol. The structures of the synthesized compounds were elucidated by using IR, 13C NMR, 1H NMR spectroscopy and elemental analysis. All the compounds were tested in vitro antioxidant activity with free radical scavenging method using by 1,1-diphenyl-2-picryl hydrazyl (DPPH). The results were given with calculated IC50 values.

Özet

Yeni schiff bazlı isatinler, hidrazin, 5-sübstitütentli isatinler ve çeşitli aldehitlerin etil alkolde geri soğutucu altındaki tepkimesi sonucu elde edilmiştir. Sentezlenen bileşiklerin yapısı IR, 13C NMR, 1H NMR spektroskopik veriler ve elementel analiz sonuçlar ile aydınlatılmıştır. Sentezlenen bileşiklerin antioksidan aktivite testleri 2,2-difenil-1-pikril hidrazil (DPPH) radikal giderme yöntemi ile yapılmıştır. Sonuçlar, hesaplanan IC50 (yarı maksimum inhibitör derişim) değerleri ile verilmiştir.

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Cite This Article

MUĞLU, H., YAKAN, H. (2020). Preparation, Characterization, and Antioxidant Features of Some New Schiff Bases Derived from Isatins and Hydrazine. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Cilt: 10 - Sayı: 1, 439–447. https://ajindex.com/articles/256995

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