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Journals / Hacettepe Journal of Biology and Chemistry / 2014 / Cilt: 42 - Sayı: 4

Surface Modifications of Cationic Polyamidoamine PAMAM Dendrimers

Katyonik Poliamidoamin PAMAM Dendrimerlerin Yüzey Modifikasyonları

Parisa GOLSHAEİ
Negar Taghavi POURİANAZAR
Pages
485–497
Publication Date
2014-11-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Then, various modification routes with the aim of decreasing the cytotoxicity of PAMAM dendrimers are presented and discussed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:PAMAM dendrimers are a new class of macromolecular polymers, with a highly branched three-dimensional structure that provides a high degree of surface functionality and versatility.
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Key Findings & Data:These nanospherical polymers possess exclusive properties which make them potential carriers for drug and gene delivery.
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Conclusion & Impact:Then, various modification routes with the aim of decreasing the cytotoxicity of PAMAM dendrimers are presented and discussed.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:PAMAM dendrimer · Yüzey modifikasyonu · PEGilasyon

Abstract

PAMAM dendrimers are a new class of macromolecular polymers, with a highly branched three-dimensional structure that provides a high degree of surface functionality and versatility. These nanospherical polymers possess exclusive properties which make them potential carriers for drug and gene delivery. PAMAM dendrimers allow the precise control of size, shape and placement of functional groups that is desirable for many life science applications. However, positive charge at the surface renders cytotoxicity to the cationic PAMAM dendrimers, which limits their clinical usefulness. Modification of dendrimer surface groups is one of the methods available in order to reduce the toxicity and improve their biocompatibility. In this review, firstly a brief description is provided about the characteristics and structure of PAMAM dendrimers. Then, various modification routes with the aim of decreasing the cytotoxicity of PAMAM dendrimers are presented and discussed.

Özet

P AMAM dendrimerler, makromoleküler polimelerin yeni bir sınıfı olarak, çok dallı ve üç boyutlu yapıları aracılığıyla yüksek derecede yüzey fonksiyonelliği ve çok yönlülük sağlar. Bu nanoküresel polimerler, kendilerini ilaç taşıma ve gen aktarımı için potansiyel hale getiren seçkin özelliklere sahiptir. PAMAM dendrimerlerin, fonksiyonel grupların boyutu, şekli ve yerleşimi konusunda kesin kontrol sağlaması, birçok yaşam bilim uygulamaları tarafından kullanımlarının istenmesine neden olmuştur. Fakat, yüzeylerindeki pozitif yük, katyonik PAMAM dendrimerlere sitotoksite vererek, klinik kullanımlarını sınırlandırmaktadır. Dendrimer yüzey gruplarının modifikasyonu, toksisiteyi azaltmak ve biyouyumluluğu geliştirmek amacıyla uygulanan mevcut yöntemlerden biridir. Bu derlemede ilk olarak PAMAM dendrimerlerin özellikleri ve yapısı hakkında kısa bir açıklama sağlanmıştır. Daha sonrasında ise PAMAM dendrimerlerin sitotoksisitesini azaltılmak amaçlı çeşitli modifikasyon yöntemleri sunulmuş ve tartışılmıştır

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Cite This Article

GOLSHAEİ, P., POURİANAZAR, N. T. (2014). Surface Modifications of Cationic Polyamidoamine PAMAM Dendrimers. Hacettepe Journal of Biology and Chemistry, Cilt: 42 - Sayı: 4, 485–497. https://ajindex.com/articles/256199

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