Journals / Hacettepe Journal of Biology and Chemistry / 2018 / Cilt: 46 - Sayı: 1

Functional Polysaccharides Blended Collagen Cryogels

Pages
113–120
Publication Date
2018-03-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results show that, these collagen cryogels with their polysaccharides functional components have proper chemical and thermal characteristics and show good bio and hemocompatibility.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Researches investigate new types of scaffolds for tissue engineering and regenerative medicine applications to support cell proliferation and growth as well as tissue repair and regeneration.
📊
Key Findings & Data:Although, there are several types of polymeric materials and various kinds of preparation techniques are already used today; there is still no consensus on the answer of the question “what is the best scaffold for tissue repair and regeneration?”.
💡
Conclusion & Impact:Results show that, these collagen cryogels with their polysaccharides functional components have proper chemical and thermal characteristics and show good bio and hemocompatibility.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Collagen · polysaccharides · cryogels

Abstract

Researches investigate new types of scaffolds for tissue engineering and regenerative medicine applications to support cell proliferation and growth as well as tissue repair and regeneration. Although, there are several types of polymeric materials and various kinds of preparation techniques are already used today; there is still no consensus on the answer of the question “what is the best scaffold for tissue repair and regeneration?”. Cryogels, which is a kind of hydrogels and, cryogelation, which is the technique for cryogel preparation, are rather new for tissue engineering applications. Here in this study, dextran and carboxymethyl cellulose functional polysaccharides blended collagen cryogels were prepared and characterized by chemical, structural and biological evaluations. Results show that, these collagen cryogels with their polysaccharides functional components have proper chemical and thermal characteristics and show good bio and hemocompatibility. Therefore, these cryogels can be used as a candidate scaffold for tissue engineering and regenerative medicine applications.

🔖

Cite This Article

ODABAŞ, S. (2018). Functional Polysaccharides Blended Collagen Cryogels. Hacettepe Journal of Biology and Chemistry, Cilt: 46 - Sayı: 1, 113–120. https://ajindex.com/articles/255748

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. R.M. Nerem, A. Sambanis, Tissue engineering: from biology to biological substitutes, Tissue Eng., 1 (1995) 3-13.
  2. S. Yang, K.F. Leong, Z. Du, C.K. Chua, The design of scaffolds for use in tissue engineering. Part I. Traditional factors, Tissue Eng., 7 (2001) 679-689.
  3. L.E. Freed, G. Vunjak-Novakovic, R.J. Biron, D.B. Eagles, D.C. Lesnoy, S.K. Barlow, R. Langer, Biodegradable polymer scaffolds for tissue engineering, Biotechnol., 12 (1994) 689-693.
  4. B.P. Chan, K.W. Leong, Scaffolding in tissue engineering: general approaches and tissue-specific considerations, European spine journal: official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 17 Suppl. 4 (2008) 467-479.
  5. S.J. Hollister, R.D. Maddox, J.M. Taboas, Optimal design and fabrication of scaffolds to mimic tissue properties and satisfy biological constraints, Biomaterials, 23 (2002) 4095-4103.
  6. V.I. Lozinsky, I.Y. Galaev, F.M. Plieva, I.N. Savina, H. Jungvid, B. Mattiasson, Polymeric cryogels as promising materials of biotechnological interest, Trends Biotechnol., 21 (2003) 445-451.
  7. M. Andac, I.Y. Galaev, H. Yavuz, A. Denizli, Molecularly imprinted cryogels for human serum albumin depletion in: Affinity Chromatography: Methods and Protocols, S. Reichtelt, ed., Methods in Molecular Biology Series, volume 1286, pp 233-237, Humana Press, 2015.
  8. D. Cimen, F. Yilmaz, I. Percin, D. Turkmen, A. Denizli, Dye affinity cryogels for plasmid DNA purification, Mater. Sci. Eng. Mater. Biol. Appl., 56 (2015) 318-324.
  9. A. Kumar, A. Bhardwaj, Methods in cell separation for biomedical application: cryogels as a new tool, Biomed. Mater., 3 (2008) 1-12.
  10. M. Uygun, A.A. Karagozler, A. Denizli, Molecularly imprinted cryogels for carbonic anhydrase purification from bovine erythrocyte, Artif. Cells Nanomed. Biotechnol., 42 (2014) 128-137.
  11. N. Bolgen, I. Vargel, P. Korkusuz, E. Guzel, F. Plieva, I. Galaev, B. Matiasson, E. Piskin, Tissue responses to novel tissue engineering biodegradable cryogel scaffolds: an animal model, J. Biomed. Mater. Res. A, 91 (2009) 60-68.
  12. C.H. Chen, C.Y. Kuo, Y.J. Wang, J.P. Chen, Dual function of glucosamine in gelatin/hyaluronic acid cryogel to modulate scaffold mechanical properties and to maintain chondrogenic phenotype for cartilage tissue engineering, Int. J. Mol. Sci., 17 (2016) 1-22.
  13. M.V. Konovalova, P.A. Markov, E.A. Durnev, D.V. Kurek, S.V. Popov, V.P. Varlamov, Preparation and biocompatibility evalua