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Journals / Hacettepe Journal of Biology and Chemistry / 2018 / Cilt: 46 - Sayı: 2

Cholesterol Adsorption from Artificial Human Plasma with Molecular Imprinted Polymeric Nanostructures

Tülden İNANAN
Nalan TÜZMEN
Pages
285–296
Publication Date
2018-06-03
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Under optimum conditions, considerably high cholesterol was adsorbed from hypercholesterolemic plasma (95.33 %).

📌 3 Key Takeaways

🎯
Objective & Hypothesis:This study reports cholesterol adsorption from artificial human plasma using MIP nanostructures prepared with different template:monomer ratios.
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Key Findings & Data:The adsorption capacity of CP is 19.9% and 16.1% higher than those of C3P and CP3, respectively and adsorption capacity of CP is significantly higher than NIP nanostructures.
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Conclusion & Impact:Under optimum conditions, considerably high cholesterol was adsorbed from hypercholesterolemic plasma (95.33 %).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Cholesterol · molecular imprinting · plasma

Abstract

This study reports cholesterol adsorption from artificial human plasma using MIP nanostructures prepared with different template:monomer ratios. The adsorption capacity of CP is 19.9% and 16.1% higher than those of C3P and CP3, respectively and adsorption capacity of CP is significantly higher than NIP nanostructures. All selectivity coefficients and relative selectivity values were higher than 1 for artificial human plasma. Under optimum conditions, considerably high cholesterol was adsorbed from hypercholesterolemic plasma (95.33 %).

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Cite This Article

İNANAN, T., TÜZMEN, N. (2018). Cholesterol Adsorption from Artificial Human Plasma with Molecular Imprinted Polymeric Nanostructures. Hacettepe Journal of Biology and Chemistry, Cilt: 46 - Sayı: 2, 285–296. https://ajindex.com/articles/255654

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References (11)

  1. S.N. Hashim, R.I. Boysen, L.J. Schwarz, B. Danylec, M.T. Hearn, A comparison of covalent and noncovalent imprinting strategies for the synthesis of stigmasterol imprinted polymers, J. Chromatogr. A, 1359 (2014) 35-43
  2. E. Verheyen, J.P. Schillemans, M. Wijk, M.A. Demeniex, W.E. Hennink, C.F. Nostrum, Challenges for the effective molecular imprinting of proteins, Biomaterials, 32 (2011) 3008-3020.
  3. M. Behbahani, S. Bagheri, M.M. Amini, H.S. Abandansari, H.R. Moazami, A. Bagheri, Application of a magnetic molecularly imprinted polymer for the selective extraction and trace detection of lamotrigine in urine and plasma samples, J. Sep. Sci., 37 (2014) 1610-1616.
  4. C. Lu, H. Li, M. Xu, S. Wang, G. Li, W. Zhong, S.Qin, Preparation of nicotine-imprinted monolith by insitu surface imprinting onto internal hole surface of macroporous silica for selective enrichment and separation of nicotine in environmental water sample, Sep. Sci. Technol., 50 (2015) 2124-2133.
  5. J. Ding, F. Zhang, X. Zhang, L. Wang, C. Wang, Q. Zhao, Y. Xu, L. Ding, N. Ren, Determination of roxithromycin from human plasma samples based on magnetic surface molecularly imprinted polymers followed by liquid chromatography-tandem mass spectrometer, J. Chromatogr. B, 1021 (2016) 221-228.
  6. X. Xu, S. Liang, X. Meng, M. Zhang, Y. Chen, D. Zhao, Y. Li, A molecularly imprinted polymer for the selective solid-phase extraction of dimethomorph from ginseng samples, J. Chromatogr. B, 988 (2015) 182-186.
  7. X. Kong, R. Gao, X. He, L. Chen, Y. Zhang, Synthesis and characterization of the core–shell magnetic molecularly imprinted polymers (Fe3O4@MIPs) adsorbents for effective extraction and determination of sulfonamides in the poultry feed, J. Chromatogr. A, 1245 (2012) 8-16.
  8. M. Andaç, I.Y. Galaev, A. Denizli, Affinity based and molecularly imprinted cryogels: Applications in biomacromolecule purification, J. Chromatogr. B, 1021 (2016) 69-80.
  9. J. Yang, Z. Wang, T. Zhou, X. Song, Q. Liu, Y. Zhang, L. He, Determination of cyproheptadine in feeds using molecularly imprinted solid-phase extraction coupled with HPLC, J. Chromatogr. B, 990 (2015) 39-44.
  10. C. Hwang, W.C. Lee, Chromatographic characteristics of cholesterol imprinted polymers prepared by covalent and non-covalent imprinting methods, J. Chromatogr. A, 962 (2002) 69-78.
  11. E. Caro, N. Masque, R.M. Marce, F. Borrull, P.A.G. Cormack, D.C. Sherington, Non-covalent and semicovalent molecularly imprinted polymers for selective on-line solid-phase extraction of 4-nitrophenol from