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Journals / Gazi University Journal of Science / 2009 / Cilt: 22 - Sayı: 2

Gene Regulation and Transcriptional Regulation in Bacteria

in Bacteria

İsmail AKYOL
Uğur ÇÖMLEKÇIOĞLU
Pages
77–82
Publication Date
2010-03-22
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Key Words: Transcription regulation, FNR, CAP, FLP.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The catabolite gene activator protein (CAP) and the fumurate nitrate reductase (FNR) are two founder members of the growing CRP-FNR protein superfamily.
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Key Findings & Data:The consensus FNR binding site (TTGAT-N4-ATCAA) closely resembles that of CRP to the extent that both contain a common core motif (NTGAN-N4-NTCAN).
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Conclusion & Impact:Key Words: Transcription regulation, FNR, CAP, FLP.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Transcription regulation · FNR · CAP

Abstract

The catabolite gene activator protein (CAP) and the fumurate nitrate reductase (FNR) are two founder members of the growing CRP-FNR protein superfamily. The consensus FNR binding site (TTGAT-N4-ATCAA) closely resembles that of CRP to the extent that both contain a common core motif (NTGAN-N4-NTCAN). The transcription factor FNR plays a role in altering gene expression between aerobic and anaerobic conditions but CRP regulators control the response to glucose starvation. Protein DNA interactions occur between the regulatory protein and DNA at the corresponding promoter using the consensus either CRP or FNR binding sites. Successful transcriptional activation generally requires contact between a DNA-bound activator and RNA polymerase in order to generate on effective complex. CRP promoters are grouped into two classes depending on the location of DNA binding site. Class I promoters contains transcription activator binding sites centered near position -61.5, -71, -82 or -92. Class II promoters the regulator proteins bind to a site centered at or near -41.5 so three possible contacts, αCTD-AR1, αNTD-AR2 and δ70-AR3, occur between regulator and RNA polymerase. FNR and FLP act as a class II activator. Key Words: Transcription regulation, FNR, CAP, FLP.

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Cite This Article

AKYOL, İ., ÇÖMLEKÇIOĞLU, U. (2010). Gene Regulation and Transcriptional Regulation in Bacteria. Gazi University Journal of Science, Cilt: 22 - Sayı: 2, 77–82. https://ajindex.com/articles/255148

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