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Journals / Ulusal Travma ve Acil Cerrahi Dergisi / 2016 / Cilt: 22 - Sayı: 6

The acute effects of thymoquinone on acute peripheral nerve injury: an experimental study

Timokinonun akut periferik sinir hasarı üzerine akut etkisi: Deneysel bir çalışma

İsmail GULSEN
Hakan AK
Mikail KARA
Abdülsemat GÖKALP
Veysel AKYOL
ÖMER FARUK KOÇAK
MURAT ÇETİN RAĞBETLİ
Pages
526–530
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Axon diameter, myelin thickness, and axon density were measured.RESULTS: There were no significant differences in axon diameter, myelin thickness, or axon density among groups.CONCLUSION: TQ has no acute therapeutic effect on acute nerve injury.

📌 3 Key Takeaways

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Objective & Hypothesis:BACKGROUND: The purpose of this study was to evaluate the acute effects of thymoquinone (TQ) on acute nerve injury.METHODS: A rat model of crush injury of the sciatic nerve was used.
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Key Findings & Data:Animals were divided into 3 groups: control, trauma, and TQ treatment groups (n=6 per group).
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Conclusion & Impact:Axon diameter, myelin thickness, and axon density were measured.RESULTS: There were no significant differences in axon diameter, myelin thickness, or axon density among groups.CONCLUSION: TQ has no acute therapeutic effect on acute nerve injury.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

BACKGROUND: The purpose of this study was to evaluate the acute effects of thymoquinone (TQ) on acute nerve injury.METHODS: A rat model of crush injury of the sciatic nerve was used. Animals were divided into 3 groups: control, trauma, and TQ treatment groups (n=6 per group). Seven days after injury, sciatic nerve specimens were obtained from the site of the injury and analyzed histologically and stereologically. Axon diameter, myelin thickness, and axon density were measured.RESULTS: There were no significant differences in axon diameter, myelin thickness, or axon density among groups.CONCLUSION: TQ has no acute therapeutic effect on acute nerve injury.

Özet

AMAÇ: Bu çalışmanın amacı akut sinir hasarında timokinonun akut dönem etkilerini değerlendirmektir. GEREÇ VE YÖNTEM: Çalışma sıçan sinirinde siyatik sinirde ezilme modeli geliştirilerek yapıldı. Sıçanlar kontrol, travma ve timokinon tedavi grubu olmak üzere üç gruba ayrıldı (n=6). Sinir hasarından yedi gün sonra hasar yerinden siyatik sinir doku örnekleri alındı. Bu doku örneklerinde histolojik ve steryolojik çalışma yapıldı. Akson çapı, myelin kalınlığı ve akson yoğunluk ölçümleri yapıldı. BULGULAR: Gruplar arasında akson çapı, miyelin kalınlığı ve akson yoğunluğu bakımından anlamlı bir farklılık görülmedi. TARTIŞMA: Timokinon akut sinir hasarı üzerinde akut dönemde iyileştirici etkiye sahip değildir.

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Cite This Article

GULSEN, İ., AK, H., KARA, M., GÖKALP, A., AKYOL, V., KOÇAK, Ö. F., RAĞBETLİ, M. Ç. (2016). The acute effects of thymoquinone on acute peripheral nerve injury: an experimental study. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 22 - Sayı: 6, 526–530. https://ajindex.com/articles/323751

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