The structure of this alkaloid was elucidated by means of comprehensive spectroscopic methods (1D and 2D NMR, MS, UV, IR).
📌 3 Key Takeaways
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Objective & Hypothesis:A minor alkaloid, namely gracilamine, was isolated from Galanthus gracilis.
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Key Findings & Data:This was the first example of a pentacyclic dinitrogenous alkaloid isolated from a member of Amaryllidaceae.
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Conclusion & Impact:The structure of this alkaloid was elucidated by means of comprehensive spectroscopic methods (1D and 2D NMR, MS, UV, IR).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Gracilamine · Galanthus gracilis · Pentacyclic and Dinitrogenous Alkaloids
Abstract
A minor alkaloid, namely gracilamine, was isolated from Galanthus gracilis. This was the first example of a pentacyclic dinitrogenous alkaloid isolated from a member of Amaryllidaceae. The structure of this alkaloid was elucidated by means of comprehensive spectroscopic methods (1D and 2D NMR, MS, UV, IR).
Özet
A minor alkaloid, namely gracilamine, was isolated from Galanthus gracilis. This was the first example of a pentacyclic dinitrogenous alkaloid isolated from a member of Amaryllidaceae. The structure of this alkaloid was elucidated by means of comprehensive spectroscopic methods (1D and 2D NMR, MS, UV, IR).
ÜNVER, N., KAYA, G. İ. (2005). An Unusual Pentacyclic Dinitrogenous Alkaloid from Galanthus gracilis. Turkish Journal of Chemistry, Cilt: 29 - Sayı: 5, 547–553. https://ajindex.com/articles/253798
M. Suffness and G.A. Cordell, “Antitumor Alkaloids” in The Alkaloids Chemistry and Pharmacology, Vol. 25, ed. A.R. Brossi, pp. 198-212,
Academic Press Inc., New York, 1985.
B. Gabrielsen, T.P. Monath, J.W. Huggins, D.F. Kefauver, G.R. Pettit, G. Groszek, M. Hollingshead, J.J. Kirsi, W.M. Shannon, E.M. Schubert, J. Dare, B. Ugarkar, M.A.Ussery and M.J. Phelan, J. Nat. Prod. 55, 1569-1581 (1992). S. L´opez, J. Bastida, F. Viladomat and C. Codina, Life Sciences 71, 2521-2529 (2002).
M. Heinrich and H.L. Teoh, J. Ethnopharm. 92, 147-162 (2004).
S. Noyan, G. Rentsch, M. Onur, T. Gozler, B. Gozler and M. Hesse, Heterocycles 48, 1777-1791 (1998).
N. Unver, S. Noyan, T. G¨ozler, M.A. ¨On¨ur, B. G¨ozler and M. Hesse, Planta Med. 65, 347-350 (1999).
N. Unver, S. Noyan, B. G¨ozler, T. G¨ozler, C. Werner and M. Hesse, Heterocycles 55, 641-652 (2001). O. Hoshino, “The Amaryllidaceae Alkaloids” in The Alkaloids Chemistry and Pharmacology, Vol. 51, ed. G.A. Cordell, pp. 323-424,
Academic Press Inc., New York, 1998.
J. Bastida, F. Viladomat and C. Codina, “Narcissus Alkaloids” in Studies in Natural Product Chemistry, Vol. 20, ed. Atta-ur-Rahman, pp. 323-405,