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Journals / Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi / 2020 / Cilt: 7 - Sayı: 1

Iodine-Catalyzed Addition of Thiophenol to Isoindolsubstitue Chalcones

İsoindolsübstitüe-kalkon Türevlerine İyot Katalizli Tiyofenol Katılması

Yakup BUDAK
Ahmet Doğan ÇAKIR
Oğuz ÖZBEK
Meliha Burcu GÜRDERE
Mustafa CEYLAN
Pages
161–169
Publication Date
2020-06-28
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The structures of the obtained new compounds were clarified by 1H-NMR, 13C-NMR, FT-IR and Elemental Analysis spectroscopic methods.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Chalcone and isoindol derivatives possess significant biological activities.
📊
Key Findings & Data:In this work, new β-mercapto carbonyl compounds (5a-j), (3aR,4S,7R,7aS)-2-(4-(3-(phenylthio)-3-(aryl)pyridyl)aminocarbonyl-propanol)phenyl)-3a,4,7,7a-tetrahydro-1H-7-methanoisoindole-1,3(2H)-dione), were obtained by molecular iodine-catalyzed addition of thiophenol to isoindol substituted chalcone derivatives (3a-j) in high yields.
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Conclusion & Impact:The structures of the obtained new compounds were clarified by 1H-NMR, 13C-NMR, FT-IR and Elemental Analysis spectroscopic methods.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Chalcone · Isoindole · Thiophenol

Abstract

Chalcone and isoindol derivatives possess significant biological activities. Also, ıt is known that hybrid molecules carrying these two units in the same structure show biological activity. In addition, -mercaptans are used as the starting material for the synthesis of some bioactive compounds. In this work, new β-mercapto carbonyl compounds (5a-j), (3aR,4S,7R,7aS)-2-(4-(3-(phenylthio)-3-(aryl)pyridyl)aminocarbonyl-propanol)phenyl)-3a,4,7,7a-tetrahydro-1H-7-methanoisoindole-1,3(2H)-dione), were obtained by molecular iodine-catalyzed addition of thiophenol to isoindol substituted chalcone derivatives (3a-j) in high yields. The structures of the obtained new compounds were clarified by 1H-NMR, 13C-NMR, FT-IR and Elemental Analysis spectroscopic methods.

Özet

Kalkon ve isoindol türevleri önemli biyolojik aktivitelere sahip bileşiklerdir. Bu iki birimi aynı yapıda taşıyan hibrit moleküllerinde biyolojik aktivite gösterdikleri bilinmektedir. Ayrıca β-merkaptanlar bazı biyoaktif bileşiklerin sentezi için başlangıç materyali olarak kullanılmaktadırlar. Bu çalışmada, isoindolsübstitüe-kalkon türevlerine (3a-j) moleküler iyot katalizörlüğünde tiyofenol katılarak yeni β-merkapto karbonil bileşikleri, ((3aR,4S,7R,7aS)-2-(4-(3-(feniltiyo)-3-(aril)propanol)fenil)-3a,4,7,7a-tetrahidro-1H-4,7-metanisoindol-1,3(2H)-dion) (5a-j) yüksek verimler ile elde edildi. Elde edilen yeni bileşiklerin yapıları 1H-NMR, 13C-NMR, FT-IR ve Elementel Analiz spektroskopik yöntemleri kullanılarak aydınlatıldı.

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Cite This Article

BUDAK, Y., ÇAKIR, A. D., ÖZBEK, O., GÜRDERE, M. B., CEYLAN, M. (2020). Iodine-Catalyzed Addition of Thiophenol to Isoindolsubstitue Chalcones. Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi, Cilt: 7 - Sayı: 1, 161–169. https://ajindex.com/articles/251550

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