SavedAdd your journal

Journals / GORM:Gynecology Obstetrics & Reproductive Medicine / 2010 / Cilt: 16 - Sayı: 1

Primer infertil türk erkeklerindeki kromozom bozuklukları

Chromosome abnormalities in Turkish men with primary infertility

Tayfun GÜNGÖR
Mine PEKTAŞ KANAT
Müfit M. GÜNEL
Leyla MOLLAMAHMUTOĞLU
Pages
32–36
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Klinefelter syndrome was detected to be the most frequent chromosomal abnormality with an overall rate of 10.5%.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:OBJECTIVE: The present study aims to identify the prevalence and types of chromosome anomalies among Turkish men with primary infertility.
📊
Key Findings & Data:STUDY DESIGN: A case-control study was undertaken in 474 Turkish men with primary infertility and 450 phenotypically normal fertile men selected for the control group.
💡
Conclusion & Impact:Klinefelter syndrome was detected to be the most frequent chromosomal abnormality with an overall rate of 10.5%.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: The present study aims to identify the prevalence and types of chromosome anomalies among Turkish men with primary infertility. STUDY DESIGN: A case-control study was undertaken in 474 Turkish men with primary infertility and 450 phenotypically normal fertile men selected for the control group. RESULTS: Azoospermia is defined to be the most frequent spermiogram abnormality within infertile men, followed by oligoasthenoteratozoospermia. Chromosomal abnormalities were demonstrated to occur significantly more in azoospermic subjects (28.3%) compared to other infertile subjects (11.5%) and fertile men (0.8%). Klinefelter syndrome was detected to be the most frequent chromosomal abnormality with an overall rate of 10.5%. Azoospermia Factor (AZF) microdeletions occur statistically similar among azoospermic men (4.2%) and other infertile men (2.3%), with a total frequency of 3.2%. CONCLUSION: The high rate of chromosomal anomalies among infertile Turkish men strongly suggests the need for routine cytogenetic analysis prior to the application of assisted reproduction techniques.

Özet

AMAÇ: Sunulan çalışmada, primer infertilite nedeniyle hekime başvuran Türk erkeklerindeki kromozom bozukluklarının belirlenmesi amaçlanmaktadır. GEREÇ VE YÖNTEM: Sunulan çalışmada primer infertilite saptanan 474 Türk erkeği ile fenotipik olarak normal görünen ve fertil olan 450 Türk erkeği, kromozom bozuklukları bakımından karşılaştırılmıştır. BULGULAR: Primer infertil Türk erkekkelrinde en sık görülen spermiogram bozukluğu olan azospermiyi oligoastenoteratozospermi izlemektedir. Kontrol grubuna ve diğer infertil erkeklere kıyasla, azospermik erkeklerde kromozom bozukluklarının daha sık olduğu bulunmuştur (%0.8 vs %11.5 vs 28.3%). Çalışmada incelenen tüm erkeklerde en çok görülen kromozom bozukluğu olan Klinefelter sendromunun sıklığı %10.5 olarak hesaplanırken azospermik erkeklerde bu değer %16.5 olmaktadır. Çalışmaya dahil edilen tüm erkeklerin %3.2’sinde belirlenen Azospermi Faktörü (AZF) mikrodelesyonları, azospermik erkeklerde ve diğer infertil erkeklerde benzer oranda görülmektedir (%4.2 vs %2.3). SONUÇ: Primer infertil Türk erkeklerindeki kromozom bozukluğu sıklığının yüksek bulunması, yardımcı üreme teknikleri uygulanmadan önce rutin olarak gerçekleştirilen sitogenetik analizin gerekliliğini ve önemini vurgulamaktadır.

🔖

Cite This Article

GÜNGÖR, T., KANAT, M. P., GÜNEL, M. M., MOLLAMAHMUTOĞLU, L. (2010). Primer infertil türk erkeklerindeki kromozom bozuklukları. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 16 - Sayı: 1, 32–36. https://ajindex.com/articles/227543

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (17)

  1. Siffroi JP. Genetic aspects of male sterility. J Gynecol Obstet Biol Reprod. 2005;34 (1 Pt 2): 1S15-9
  2. Mau-Holzmann UA. Somatic chromosomal abnormalities in infertile men and women. Cytogenet Genome Res. 2005;111(3-4):317-36
  3. Quilter C. Chromosomal abnormalities and male infertility. Indian J Med Res. 2005;122(1):11-2 4. Engel W, Adham IM, Navernia K, et al. Genetic causes of male infertility. Verh Dtsch Ges Pathol 2004; (88):130-5 5. Delgado Martin JA, Blazquez Izquierdo J, Silmi Moyaro A. The management of azoospermic patient. Arch Esp Urol 2004;57(9):1021-33
  4. Sharlip ID, Jarow JP, Bekler AM, et al. Best practice policies for male infertility, Fertil Steril 2002:77:873
  5. Maduro MR, Lamb DJ. Understanding new genetics of male infertility. J Urol. 2002;168(5):2197-205
  6. Huynh T, Mollard R, Trounson A. Selected genetic factors associated with male infertility. Hum Reprod Update. 2002; 8(2):183-98
  7. Fernandez-Salgado E, Alvarez-Nava F, Borjas-Fajardo F, et al. Molecular analysis of microdeletions of the Y chromosome in Venezuelan males with idiopathic infertility. Invest Clin. 2006; 47(4):395-403
  8. Gonsalves J, Turek PJ, Schlegel PN, et al. Recombination in men with Klinefelter’s syndrome. Reproduction 2005; 130(2): 223-9
  9. Gooren LJ, de Ronde W. Some new aspects of the Klinefelter syndrome. Ned Tijdschr Geneeskd. 2006; 150(49):2693-6
  10. World Health Organization, Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction, 4th, Cambridge University Press, 1999
  11. Jarow JP, Espeland M. Evaluation of the azoospermic patient. J Urol 2002;142:62
  12. Mitelman F. An Internatioal System for Human Cytogenetic Nomenclature. ISCN 1995, Karger, Basel, Switzerland
  13. Retref AE, van Zyl JA, Menkveld R. Chromosome studies in 496 infertile males with a sperm count below 10 million/ ml. Hum Genet 1984;66(2-3):162-4
  14. Rao RL, Babu KA, Kanakavalli MR. Prevalence of chromosome defects in azoospermic and oligoasthenoteratozoospermic South Indian infertile men attending an infertility clinic. Reprod Biomed Online 2005;10(4):467-72
  15. Nagvenkar P, Desai K, Hinduja I. Chromosomal studies in infertile men with oligozoospermia and non,obstructive azoospermia. Indian J Med Res 2005; 122(1): 34-42
  16. Elghezal H, Hidar S, Braham R, et al. Chromosome abnormalities in one thousand infertile males with nonobstructive sperm disorders. Fertil Steril 2006; 86(6):1792-5
  17. Lissitsina J, Mikelsaar R, Punab M. Cytogenetic an