SavedAdd your journal

Journals / GORM:Gynecology Obstetrics & Reproductive Medicine / 2008 / Cilt: 14 - Sayı: 3

Gonadotropinin ICSI sikluslarında ovulasyonu tetiklemek amacıyla farklı kullanım yolları ile body mass index ilişkisinin karşılaştırılması

Comparison of the different type and the different routes of administration of human chorionic gonadotropin during trigger of ovulation in icsı cycles and the relation with body mass index

Özlem MORALOĞLU
Sevtap KILIÇ
MÜZEYYEN GÜLNUR ÖZAKŞİT
Beril YÜKSEL
Ayça IŞIK
Leyla MOLLAMAKMUTOĞLU
Pages
172–178
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION: When comparing the different administration routes of HcG , the S.C. route of HcG seems to be safer and useful for obese patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:OBJECTIVE: To confirm that HcG levels in follicular fluid and serum after intramuscular (IM) or subcutaneous(SC) administration of purified (p)HcG and SC administration of recombinant(r)HcG and their associations with body mass index (BMI) and oocytes maturation in ICSI cyle.
📊
Key Findings & Data:Group1(n:56) received IMpHcG and Group2(n:57) received SCpHcG and Group3( n:47) received rHcG .
💡
Conclusion & Impact:CONCLUSION: When comparing the different administration routes of HcG , the S.C. route of HcG seems to be safer and useful for obese patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: To confirm that HcG levels in follicular fluid and serum after intramuscular (IM) or subcutaneous(SC) administration of purified (p)HcG and SC administration of recombinant(r)HcG and their associations with body mass index (BMI) and oocytes maturation in ICSI cyle. STUDY DESIGN: We used pHcG or rHcG for triggering ovulation of all patients . Group1(n:56) received IMpHcG and Group2(n:57) received SCpHcG and Group3( n:47) received rHcG . Serum and follicular fluid HcG levels were measured on the day of oocytes retrieved as primary outcome. RESULT: There was a significant difference on serum and follicular fluid HcG levels among three groups. No correlation was found between BMI and oocytes maturation for Group1 and Group2. But there was a significantly negative correlation between BMI and oocytes maturation in Group3. CONCLUSION: When comparing the different administration routes of HcG , the S.C. route of HcG seems to be safer and useful for obese patients.

Özet

Çalışmamızda ICSI uygulamalarında (p) HcG'nın subkütan (SC) veya intramusküler (İM) kulanımındaki foliküler sıvı ve kan HcG düzeyleri ile recombinant(r)HcG nin subkütan uygu-lanımı ile elde edilen değerler ile body mass index (BMI) ve oosit maturasında ilişkiyi değerlendirmeyi amaçladık. Ovulasyonu tetiklemek amacıyla pHcG veya rHcG kullanıldı. Grupl (n:56) İM pHcG, Grup2 (n:57) SC pHcG ve Group3 (n:47) rHcG uygulanan hastadan oluşmaktaydı. Serum ve fol-liküler sıvı HcG düzeyleri primer outcome olarak oosit toplama gününde ölçüldü. Gruplar arasında serum ve folliküler sıvı HcG düzeylerinde önemli fark izlendi. Grup 1 ve Grup 2 için BMI ve oosit matu-rasyonları arasında korelasyon izlenmedi. Fakat grup 3 için BMI ve oosit maturasyonları arasında istatiksel anlamlı olarak negatif korelasyon izlendi. HcG nin farklı kullanım yollarunı karşılaştırdığımızda SC kullanımın obez hastalar için daha güvenli ve faydalı olduğu sonucuna ulaştık

🔖

Cite This Article

MORALOĞLU, Ö., KILIÇ, S., ÖZAKŞİT, M. G., YÜKSEL, B., IŞIK, A., MOLLAMAKMUTOĞLU, L. (2008). Gonadotropinin ICSI sikluslarında ovulasyonu tetiklemek amacıyla farklı kullanım yolları ile body mass index ilişkisinin karşılaştırılması. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 14 - Sayı: 3, 172–178. https://ajindex.com/articles/227089

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (8)

  1. Trinchard-Lugan I, Khan A, Porchet HC: Pharmaco kinetics and pharmacodynamics of recombinant human chorionic gonadotropin in healthy male and female volunteers, Reprod Biomed Online 2002
  2. 15 2.Chang P, Kenley S, Bums T, Denton G, Currie K, DeVane G, O'Dea L: Recombinans human chorionic gonadotropin (rHcG) in assisted reproductive technology: Result of a clinical trial comparing two doses of rHcG (Ovidrel) to urinary hCG (Profasi) for induction of final follicular maturation in in vitro fertilization-embryo transfer, Fertil Steril 2001
  3. 74 3.Elkind-Hirsch KE, Bello S, Esparcia L, Phillips K, Sheiko A, McNichol M.Serum human chorionic gonadotropin levels are correlated with body mass index rather than route of administration in women undergoing in vitro fertilization—embryo transfer using human menopausal gonadotropin and intracytoplasmic sperm injection.Fertil Steril. 2001,75 (4):700-4. 4.Petros Stefanis, Sangeeta Das, Emil Barsoum-Derinas, Charles Kingsland, Iwan Lewis-Jones, Rafet Gazvani. Relationship between serum human Chorionic honadotrophin levels and body mass index in women undergoing in vitro fertilisation cycles. European Journal of Obtetrics and Gynecology and Reproductive Biology. 2007
  4. Dobbs, KE., Domesic DA., Domesic, JA. and Shapiro, S.S., Differences in serum follicle-stimulating hormone uptake after intramuscular and subcutaneous human menopausal gonadotropin injection. Fertil. Steril. 1994
  5. James R. Stelling, Emily T. Chapman, David Frankfurter, Doria H. Haris, Selwyn P. Oskowitz and Richard H. Reindollar. Subcutaneous versus intramuscular admintration of human chorionic gonadotropin during an in vitro fertilization cycle. Fertility and strerility. 2003
  6. Osama Salha, Tunde Dada ana Vinay Sharma. Influence of body mass index and self-adminstration of hCG on the outcome of IVF cycles: a prospective cohort study. Human Fertility. 2001
  7. Matts Wikland, Jan Borg, Ann-Sofi Forsberg, Ann-Helen Jakobsson, Peter Svalander and Urban Waldenstrom. Human chorionic honadotrophin self-adminstred by the subcutaneous route to induce oocyte maturation in an in-vitro fertilization ana embryo transfer programme. Human Reproduction. 1995
  8. Sills ES, Drews, CD., Perloe, M, Kaplan, C.R. and Tucker, M.J. Periovulatory serum human Chorionic gonadotropin (hCG) consentration following subcutaneous and intramuscular nonrecombinant hCG use during ovula-tion induction: a prospective, random