Journals / GORM:Gynecology Obstetrics & Reproductive Medicine / 2016 / Cilt: 22 - Sayı: 2

The Significance of Neutrophil-Lymphocyte Ratio and Mean Corpuscular Volume in Diagnosis of Preeclampsia

Pages
75–79
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Large-scale prospective studies with categorized study groups according to the severity of preeclampsia need to be performed to determine the optimal NLR values useful for the assessment of severity of preeclampsia.

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Objective & Hypothesis:OBJECTIVE: The aim of this study is to evaluate the diagnostic values of neutrophil to lymphocyte ratio(NLR) and mean corpuscular volume (MCV) in patients with preeclampsia.STUDY DESIGN: A retrospective analysis of patients with documented preeclampsia and uncomplicated pregnancy was carried out.
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Key Findings & Data:Two hundred and twelve women with preeclampsia, and 58 healthypregnant women as controls were included in the study.
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Conclusion & Impact:Large-scale prospective studies with categorized study groups according to the severity of preeclampsia need to be performed to determine the optimal NLR values useful for the assessment of severity of preeclampsia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: The aim of this study is to evaluate the diagnostic values of neutrophil to lymphocyte ratio(NLR) and mean corpuscular volume (MCV) in patients with preeclampsia.STUDY DESIGN: A retrospective analysis of patients with documented preeclampsia and uncomplicated pregnancy was carried out. Two hundred and twelve women with preeclampsia, and 58 healthypregnant women as controls were included in the study. NLR and MCV values were calculated fromcomplete blood count analysis.RESULTS: White blood cell, NLR and MCV values were higher in the preeclamptic patients than thoseof the controls. The study groups had similar features with regard to the maternal age, gravidity, parity,and mode of delivery. Gestational age, newborn weight, and Apgar scores of the newborns were foundlower in the preeclampsia group.CONCLUSION: NLR may be helpful in the differential diagnosis of preeclampsia. Large-scale prospective studies with categorized study groups according to the severity of preeclampsia need to be performed to determine the optimal NLR values useful for the assessment of severity of preeclampsia.

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Cite This Article

YILDIZ, Ç., KARAKUŞ, S., AKKAR, Ö. B., TOPBAŞ, T., ÇETİN, M., YANIK, A., ÇETİN, A. (2016). The Significance of Neutrophil-Lymphocyte Ratio and Mean Corpuscular Volume in Diagnosis of Preeclampsia. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 22 - Sayı: 2, 75–79. https://ajindex.com/articles/226996

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References (14)

  1. August P, Sibai BM. Preeclampsia: Clinical features and diagnosis In: UpToDate, Post, TW (Ed), UpToDate, Waltham, MA, 2014.
  2. Abalos E, Cuesta C, Grosso AL, Chou D, Say L. Global and regional estimates of preeclampsia and eclampsia: a systematic review. Eur J Obstet Gynecol Reprod Biol 2013;170:1-7. Duley L. The global impact of pre-eclampsia and eclamp- sia. Semin Perinatol 2009;33:130-7.
  3. Szpera-Gozdziewicz A, Breborowicz GH. Endothelial dysfunction in the pathogenesis of pre-eclampsia. Front Biosci 2014;19:734-46. Kenneth AB. Hematologic changes in pregnancy. In: UpToDate, Post, TW (Ed), UpToDate, Waltham, MA, 2014.
  4. Redman CW, Sargent IL. Latest advances in understand- ing preeclampsia. Science 2005;308:1592-4.
  5. Germain SJ, Sacks GP, Sooranna SR, Sargent IL, Redman CW. Systemic inflammatory priming in normal pregnancy and preeclampsia: the role of circulating syncytiotro- phoblast microparticles. J Immunol 2007;178:5949-56.
  6. Canzoneri BJ, Lewis DF, Groome L, Wang Y. Increased neutrophil numbers account for leukocytosis in women with preeclampsia. Am J Perinatol 2009;26:729-32.
  7. Redman CW, Sacks GP, Sargent IL. Preeclampsia: an ex- cessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 1999;180:499-506.
  8. Brown MA, Lindheimer MD, de Swiet M, Van Assche A, Moutquin JM. The classification and diagnosis of the hy- pertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertens Pregnancy 2001;20:9-14.
  9. Kühnert M, Strohmeier R, Stegmüller M, Halberstadt E. Changes in lymphocyte subsets during normal pregnancy. Eur J Obstet Gynecol Reprod Biol 1998;76:147-51.
  10. Ramma W, Ahmed A. Is inflammation the cause of pre- eclampsia? Biochem Soc Trans 2011;39:1619-27.
  11. Levine RJ, Thadhani R, Qian C, Lam C, Lim KH, Yu KF, et al. Urinary placental growth factor and risk of preeclampsia. JAMA 2005;293:77-85. Laresgoiti-Servitje E. A leading role for the immune sys- tem in the pathophysiology of preeclampsia. J Leukoc Biol 2013;94:247-57.
  12. Mellembakken JR, Aukrust P, Hestdal K, Ueland T, Abyholm T, Videm V. Chemokines and leukocyte activa- tion in the fetal circulation during preeclampsia. Hypertension 2001;38:394-8.
  13. Cadden KA, Walsh SW. Neutrophils, but not lymphocytes or monocytes, infiltrate maternal systemic vasculature in women with preeclampsia. Hypertens Pregnancy 2008; 27:396-405.
  14. Whittaker PG, Macphail S, Lind T. Serial hematologic changes and pregnancy outcome. Obstet Gynecol 1996;88:33-