AI Summary & Key Takeaways
AI InsightThis finding confirmed that the combination of latanoprost and bimatoprost does not have an additive intraocular pressure lowering effect through period.
📌 3 Key Takeaways
Abstract
Purpose: To evaluate the intraocular pressure (IOP) lowering effect of bimatoprost added to latanoprost in patients with primary open angle glaucoma. Materials and Methods: Twenty one patients with primary open angle glaucoma inadequately controlled on latanoprost treatment regimen were included in this study. Bimatoprost was added to latanoprost in one randomly assigned eye of each patient. Control examinations were made at baseline, 1 month and 3 months of treatment. Success was defined as 15% or more reduction in IOP from baseline. Results: At baseline examination, median IOP was 23.0 (range 21- 35) mmHg. Median IOP was 20 (range10-20) mmHg after 1 month of bimatoprost therapy and 20.0 (range10-38) mmHg after 3 months. The mean decrease in IOP was 3.7±1.4 mmHg after one month of bimatoprost therapy (p<0.05), and 2.7±1.3 mmHg after 3 months of bimatoprost therapy (p>0.05). In the adjunctive treatment, rates of clinical success were 38% at 1 month and 9.5% at 3 months. Conclusion: While, bimatoprost had statistically significant additive effect to latanoprost at one month, the same success was not seen at 3 months. This finding confirmed that the combination of latanoprost and bimatoprost does not have an additive intraocular pressure lowering effect through period.
Özet
maç: Primer açık açılı glokomlu (PAAG) olgularda, latanoprosta ilave edilen bimatoprostun göz içi basıncı (GİB) düşürücü etkisini değerlendirmek. Gereç ve Yöntem: Latanoprost tedavisi ile GİB kontrol altına alınamayan PAAG’lu 21 olgu çalışmaya alındı. Randomize olarak olguların bir gözüne bimatoprost ilave edildi. Muayeneler tedaviye başlarken ve tedavinin 1. ve 3. aylarında yapıldı. Göz içi basıncında başlangıca göre %15 ve üzeri düşme başarı olarak kabul edildi. Bulgular: İlk muayenede GİB medyan 23 mmHg (21-35 mmHg) idi. Bimatoprost tedavisine başladıktan 1 ay sonra medyan GİB 20 mmHg (10-20 mmHg), 3 ay sonra ise medyan GİB 20 mmHg (10-38 mmHg) idi. Bimatoprost tedavisinden 1 ay sonra ortalama GİB düşme miktarı 3.7±1.4 mmHg (p 0.05). Ek tedavide 1. ayda klinik başarı %38 iken, 3. aydaki klinik başarı %9.5 idi. Sonuç: Birinci ayda bimatoprostun latanoprosta aditif etkisi istatistiksel olarak anlamlı iken, aynı aditif etki 3. ayda görülemedi. Bu bulgu bimatoprost ile latanoprostun uzun dönemde aditif etkilerinin olmadığını desteklemektedir.