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Journals / Glokom Katarakt / 2006 / Cilt: 1 - Sayı: 2

Wound healing modulation after glaucoma surgery

Glokom cerrahisinden sonra yara yeri iyileşme cevabının modülasyonu

Merih ÖNAL
Hasan Ali TUFAN
Pages
77–83
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this rewiew, the spectrum of agents that are available for modulation of the scarring response following glaucoma surgery has been discussed

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Trabeculectomy has been accepted as a gold standart for the surgical treatment of glaucoma for years.
📊
Key Findings & Data:Antiproliferative agents has been used frequently in conjunction with trabeculectomy in order to decrease fibroblastic activity.
💡
Conclusion & Impact:In this rewiew, the spectrum of agents that are available for modulation of the scarring response following glaucoma surgery has been discussed
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Glokom · Yara iyileşmesi · Trabekülektomi

Abstract

Trabeculectomy has been accepted as a gold standart for the surgical treatment of glaucoma for years. Despite the improvements in surgical treatment of glaucoma; the complex pathophysiological mechanisms in conjunctival and scleral wound healing limit the surgical success. Antiproliferative agents has been used frequently in conjunction with trabeculectomy in order to decrease fibroblastic activity. Promising new wound modulation agents are currently under study. In this rewiew, the spectrum of agents that are available for modulation of the scarring response following glaucoma surgery has been discussed

Özet

Trabekülektomi, yıllardır glokom cerrahisi için altın standart olarak kabul edilmektedir. Glokom cerrahisindeki gelişmelere rağmen, konjonktival ve skleral yara iyileşmesinde rol oynayan çeşitli karmaşık patofizyolojik mekanizmalar, cerrahi başarıyı sınırlamaktadır. Bu nedenle başarı şansının arttırılması için fibroblastik aktivitenin baskılanması amacı ile glokom cerrahisinde antiproliferatif ajanlar sıklıkla kullanılmaktadır. Yara iyileşme cevabını düzenleyen yeni ajanlar ile yapılmakta olan çalışmalar halen devam etmektedir. Bu makalede glokom cerahisi sonrası skar gelişimi modulasyonunda kullanılabilecek tedavi spektrumu tartışılmıştır.

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Cite This Article

ÖNAL, M., TUFAN, H. A. (2006). Wound healing modulation after glaucoma surgery. Glokom Katarakt, Cilt: 1 - Sayı: 2, 77–83. https://ajindex.com/articles/226674

References (17)

  1. AGIS Investigators. The advanced glaucoma Interventıon study (AGIS
  2. The relationship between control of intraocular pressure and visual field deterioation. Am J Ophthalmol. 2000;130:429-430
  3. Meske MC, Heijl A, Hussein M et al.: Factors for glaucoma progression and the effect of treatment the early manifest glaucoma trial. Arch Ophthalmol. 2003;121:48-56
  4. Roothman RF, Liebmann JM, Ritch R et al.: Low-dose 5-fluorouracil trabeculectomy as initial surgery in uncomplicated glaucoma: long term follow up. Ophthalmology. 2000;107:1184-1190
  5. Parrish R, Mincler D: ‘Late endophthalmitis’: filtering surgery time bomb? Ophthalmology. 1996;103:1167-1168
  6. Franz Fankhauser: Wound Healing in Glaucoma Filtering Surgery. Kugler Pubns BV, Amsterdam/New York, 1992;3-11
  7. Baudouin C, Nordmann JP, Dennis P et al.: Efficacy of indomethacin 0.1%and flouromethalone 0.1%on conjuctival inflmmation following chronic application of antiglaucomatous drugs. Graefe’s Arch Clin Exp Ophthalmol. 2002;240:929-935
  8. Giangacomo J, Dueker DK, Adelstein E et al.: The effect of subconjunctival triamcinolone administration on glaucoma filtration. I. Trabeculectomy following subconjunctival triamcinolone. Arch Ophthalmol. 1986;104:838-841
  9. Starita RJ, Fellman RL, Spaeth GL et al.: Short and long-term effects of postoperative corticosteroids on trabeculectomy. Ophthalmology. 1985;92:932-946
  10. Nguyen KD, Lee DA: Effect of steroid and nonsteroidal antiinflammatory agents on human ocular fibroblasts. Invest Ophthalmol Vis Sci. 1992;33:2693-701
  11. Gwin TD, Stewart WC, Gwynn DR et al.: Filtration surgery in rabbits treated with diclofenac or prednisolone acetate. Ophthalmology. 1994;25:245-250
  12. Donohue EK, Cioffi GA et al.: Glaucoma surgery; are there new perspectives in perioperative pharmacology? Curr Opin Ophthalmol. 1999;10:93-98
  13. Smith MF, Doyle JW: Use of tissue plasminogen activator to revive blebs following intraocular surgery. Arch Ophthalmol. 2001;119: 09-812
  14. Rehfeldt K, Hoh H: Therapeutic and prophylactic application of TPA into the anterior chamber of the eye. Ophthalmology. 1999;96:587-593
  15. Zatla AH, Sweeney CP, Zalta AK et al.: Intracameral tissue plasminogen activator use in large series of eyes with valved glaucoma drainage implants. Arch Ophthalmol. 2002;120:487-493
  16. Del Vecchio PJ, Bizios R,Holleran LA et al.: Inhibition of human scleral fibroblast proliferation with heparin. Invest Ophthalmol Vis Sci. 1988;29:1272-1276
  17. Alvira G, H