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Journals / Glokom Katarakt / 2009 / Cilt: 4 - Sayı: 3

Vascular endothelial dysfunction and glaucoma

Endotelyal damar hastalıkları ve glokom

Hikmet ÖZÇETİN
Pages
137–142
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a results of these developments it is thought that; management of glaucoma, in the future, will depend on the idea of regulating ocular blood flow and maintaining the NO/ET-1 balance as a new treatment parameters.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The etiology of primary open angle glaucoma (POAG) is influenced by multipl risk factors.
📊
Key Findings & Data:Nitric oxide (NO) and endothelin- 1 (ET-1) are the most prominent vasoactive factors.
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Conclusion & Impact:As a results of these developments it is thought that; management of glaucoma, in the future, will depend on the idea of regulating ocular blood flow and maintaining the NO/ET-1 balance as a new treatment parameters.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The etiology of primary open angle glaucoma (POAG) is influenced by multipl risk factors. Among them intraocular pressure is the leading one and it is followed by vascular diseases. These factors may lead to ischemia of retinal nevre fibers and optic nevre head . In vascular endothelial disorders , vasoactive factors contribute to ischemic proccess by altering vascular tonus and flexibilty. Nitric oxide (NO) and endothelin- 1 (ET-1) are the most prominent vasoactive factors. Recent clinical studies about POAG and pseudoexfoliation have clearly set up that ; aqueous levels of NO and vasoendothelial factor (VEGF) tend to decrease while ET-1 levels increase. These findings suggest that blood flow reduction contributes to the pathogenesis of glaucoma . As a results of these developments it is thought that; management of glaucoma, in the future, will depend on the idea of regulating ocular blood flow and maintaining the NO/ET-1 balance as a new treatment parameters.

Özet

Primer açık açılı glokomların (PAAG) çok etkenli etyolojisi içinde en önemli risk faktörü göz içi basıncıdır. Sonra en başta gelen risk faktörünün ise, damar hastalıkları olduğu dikkati çekmektedir. Her iki faktörün sonucu ise görme sinir lifleri ve optik sinir başındaki iskemidir. Damar endotelyal hastalıklarına bağlı iskemi, damar endoteli mikro dolanımı kontrol eden, güçlü damar genişletici nitrik oksid (NO) ve damar daraltıcı (vazokonstriktör) olan endotelin-1 (ET-1) gibi vazoaktif faktörlerin salınmasından ortaya çıkan damar gerginliği ve esnekliğinin bozulması sonucudur. Yapılan çalışmalarda normale göre PAAG ve psödoeksfoliasyon glokomu (PEG) olguların göz sıvılarında NO ve VEGF düzeyinin düşük ve ET-1 in yüksek bulunması, göze gelen kan akımında azalmanın ve glokom oluşumunda damarsal düşünceyi destekler görülmektedir. Bu gelişmelerin sonucunda gelecek glokom tedavisinde gözün kan dolanımının düzenlenmesi temelinde NO/ET-1 dengesini sağlayan ajanlar gündeme gelerek yeni bir tedavi parametresi yaratacağı düşünülmektedir.

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Cite This Article

ÖZÇETİN, H. (2009). Vascular endothelial dysfunction and glaucoma. Glokom Katarakt, Cilt: 4 - Sayı: 3, 137–142. https://ajindex.com/articles/226582

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