Journals / Glokom Katarakt / 2011 / Cilt: 6 - Sayı: 2

The analysis of retinal nerve fiber layer thickness in patients with ocular hypertension and open angle glaucoma

Oküler hipertansiyon ve açık açılı glokom olgularında retina sinir lifi kalınlıklarının analizi

Pages
92–96
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

It can provide a significant contribution to other diagnostic methods.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: We aimed to compare the analysis of retinal nevre fiber layer (RNLF) thickness of the patient with ocular hypertension (OHT) and open angle glaucoma (OAG) with the analysis in normal population.
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Key Findings & Data:Material and Methods: The 167 eye of 87 subjects were examined after pupillary dilation with optical coherence tomography (Stratus OCT, model 3000).There were 3 groups; OHT group 1 (n=36), OAG group 2 (n=85), control group, group 3 (n=46).
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Conclusion & Impact:It can provide a significant contribution to other diagnostic methods.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: We aimed to compare the analysis of retinal nevre fiber layer (RNLF) thickness of the patient with ocular hypertension (OHT) and open angle glaucoma (OAG) with the analysis in normal population. Material and Methods: The 167 eye of 87 subjects were examined after pupillary dilation with optical coherence tomography (Stratus OCT, model 3000).There were 3 groups; OHT group 1 (n=36), OAG group 2 (n=85), control group, group 3 (n=46). The results of RNLF thickness (mean, superior, inferior, nasal, temporal) were recorded and compared statistically. Results: Central corneal thickness (CCT) was 577.7±24.8 &#956; in group 1 whereas 557.0±34.6 &#956; in group 2 and 541.8±32.3 &#956; in group 3. The measurement of CCT was significantly thicker in group 1 than that of group 2 and 3 (p<0.05). RNLF thicknesses (mean, superior, inferior, nasal, temporal) were 103,1±9,3, 124.3±15,8, 134.6±14.5, 85.4±19.6, 67.9±11.8 &#956; respectively in group 1, whereas 84.9±17.0, 101.5±25.6, 107.8±26.0, 67.8±18.9, 61.1±16,6 &#956; in group 2 and 98.3±11.3, 117.3±25.6, 127.9±24.1, 77.2±16, 66.2±11.4 &#956; in group 3. Although there was no statistically significant difference between group 1 and group 3 regarding the mean and all quadrant thicknesses, there was a significant difference amoung groups at all quadrants except temporal quadrant (p<0.001). Conclusion: RNLF thickness analysis with Stratus OCT is an effective and reliable method in detection and evaluation of glaucoma patients. It can provide a significant contribution to other diagnostic methods.

Özet

Amaç: Oküler Hipertansiyon (OHT) ve açık açılı glokom (AAG) olgularında retina sinir lifi kalınlığı (RSLK) analizi ve sonuçların normal popülasyonla karşılaştırılması amaçlandı. Gereç ve Yöntem: Stratus OKT (Zeiss Stratus OCT Model 3000) cihazı ile 87 hastanın 167 gözü (n) pupiller dilatasyon sonrası incelendi. OHT grup 1 (n=36), AAG grup 2 (n=85), kontrol grubu grup 3 (n=46) olarak sınıflandırıldı. Retina sinir lifi analizi (ortalama, süperior, inferior, nasal, temporal) sonuçları kaydedildi ve veriler istatistiksel olarak karşılaştırıldı. Bulgular: Sanral korneal kalınlık (SKK) ortalaması grup 1'de 577.7±24.8 μ, grup 2'de 557.0±34.6 μ ve grup 3'de 541.8±32.3 μ'du. SKK ölçümleri grup1'de, grup 2 ve grup 3'den anlamlı oranda daha kalındı (p<0.05). Retina sinir lifi kalınlığı (RSLK) analizi sonuçları (ortalama, süperior, inferior, nasal, temporal) grup 1'de sırasıyla 103.1±9.3 μ, 124.3±15.8 μ, 134.6±14.5 μ, 85.4±19.6 μ, 67.9±11.8 μ olarak ölçülürken; grup 2'de 84.9±17.0 μ, 101.5±25.6 μ, 107.8±26.0 μ, 67.8±18.9 μ, 61.1±16,6 μ ve grup 3'de 98.3±11.3 μ, 117.3±25.6 μ, 127.9±24.1 μ, 77.2±16 μ, 66.2±11.4 μ olarak saptandı. RSLK analizi sonuçlarının istatistiksel karşılaştırılmasında, grup 1 ve grup 3 arasında ortalama ve tüm kadranlarda anlamlı fark saptanmazken (p<0.05), grup 2 ile grup 1 ve 3'ün karşılaştırılmasında temporal kadran hariç diğer kadranlarda anlamlı fark tespit edildi (p<0.001). Tartışma: Stratus OKT ile RSLK analizi, glokom olgularının saptanması ve değerlendirilmesinde etkin ve güvenilir bir yöntemdir. Diğer tanı yöntemlerine önemli katkı sağlayabilir.

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Cite This Article

SARICAOĞLU, M. S., MISIR, R., KARAKURT, A., HASIRİPİ, H. (2011). The analysis of retinal nerve fiber layer thickness in patients with ocular hypertension and open angle glaucoma. Glokom Katarakt, Cilt: 6 - Sayı: 2, 92–96. https://ajindex.com/articles/226518

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