Journals / Glokom Katarakt / 2014 / Cilt: 9 - Sayı: 1

Influence of dipper and non-dipper blood pressure patterns on retinal nerve fiber thickness in nonglaucomatous hypertensive ındividuals

Glokomu olmayan hipertansif bireylerde dipper ve non-dipper kan basıncı paterninin retina sinir lifi kalınlığı üzerine etkisi

Pages
28–32
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Hypertensive patients were divided into 2 groups according to the results of 24-hour ABPM.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: To measure retinal nerve fiber layer (RNFL) thickness in hypertensive patients grouped as dipper and non-dipper ac- cording to 24-hour ambulatory blood pressure monitoring (ABPM) and to investigate the effects of different blood pressure (BP) patterns on the RNFL.
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Key Findings & Data:Materials and Methods: 25 hypertensive patients and 22 healthy controls were included in the study.
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Conclusion & Impact:Hypertensive patients were divided into 2 groups according to the results of 24-hour ABPM.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: To measure retinal nerve fiber layer (RNFL) thickness in hypertensive patients grouped as dipper and non-dipper ac- cording to 24-hour ambulatory blood pressure monitoring (ABPM) and to investigate the effects of different blood pressure (BP) patterns on the RNFL. Materials and Methods: 25 hypertensive patients and 22 healthy controls were included in the study. Hypertensive patients were divided into 2 groups according to the results of 24-hour ABPM. The dipper hypertension group (n=13) consisted of patients whose average arterial BP during night-time is less than the BP average measured during daytime by 10% and the other patients were assigned into non-dipper hypertension group (n=12). The RNFL thickness of all individuals was measured with the NFA II&#8211;GDx. Results: Average BP measured at night-time and day-time in the dipper and non-dipper groups was found to be significantly higher than the control group (p<0.05). The GDx parameter values used for the assessment of RNFL thickness-TSNIT, superior average and inferior average-were lower in the non-dipper group than both the dipper and control groups. The most obvious and statistically significant difference was observed in the inferior average value between the control group and the non-dipper group (67.03&#956;±9.15 vs. 59.31&#956;±6.38, p=0.01). Conclusion: More serious end organ damage has been demonstrated in hypertensive patients who do not show the decrease in blood pressure levels at night time (non-dipper) observed in the majority of patients. It could be useful to examine the detected thinning in RNFL thickness in non-dipper hypertension on large populations as an additional risk factor for glaucomatous damage.

Özet

Amaç: Yirmi dört saat ayaktan kan basıncı izlemi sonucu kan basıncı seyri dipper ve non-dipper olarak saptanan hipertansif hasta- larda retina sinir lifi tabakası (RSLT) kalınlığının ölçülmesi ve farklı kan basıncı paternlerinin RSLT üzerine etkisinin araştırılması. Gereç ve Yöntem: Çalışmaya hipertansiyon tanısı almış 25 hasta ile 22 sağlıklı birey dahil edildi. Hipertansif hastalar 24 saatlik ayaktan kan basıncı ölçümü yapılarak 2 gruba ayrıldı. Arteriyel kan basınçlarının gece ortalaması gündüz ortalamasından %10 ve daha fazla düşük olanlar dipper hipertansiyon grubu (n=13), düşüş olmayanlar ise non-dipper hipertansiyon grubu (n=12) olarak belirlendi. Takiben çalışmaya katılan tüm bireylerin RSLT kalınlığı NFAII-GDx cihazı ile ölçüldü. Bulgular: Dipper ve non-dipper gruplarında gündüz ve gece ölçülen ortalama kan basıncı değerlerinin kontrol grubundan anlamlı derecede yüksek olduğu tespit edildi (p<0.05). RSLT kalınlığının değerlendirilmesinde kullanılan GDx parametrelerinden TSNIT, superior average ve inferior average değerlerinin non-dipper grubunda hem kontrol grubundan hem de dipper grubundan daha düşük olduğu görüldü. En belirgin ve istatistiksel olarak anlamlı olan farkın da kontrol grubu ile non-dipper grubu arasındaki inferior average değerinde olduğu gözlendi (67.03 μ±9.15 ve 59.31μ±6.38, p=0.01). Sonuç: Gece boyunca çoğu kişide gözlenen kan basıncı düşüşünün olmadığı (non-dipper) hipertansif kişilerde hedef son organ hasarı- nın daha ciddi boyutlarda olduğu gösterilmiştir. Çalışmanın sonucunda saptanmış olan non-dipper paternde hipertansiyonun RSLT’da oluşturduğu incelme nedeniyle glokomatöz hasar için ek bir risk faktörü olarak geniş kapsamlı çalışmalarda incelenmesi faydalı olabilir.

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Cite This Article

ONARAN, Z., OĞUREL, R., EBİNÇ, H., USTA, G., ŞAHİN, Ö., ÖRNEK, K. (2014). Influence of dipper and non-dipper blood pressure patterns on retinal nerve fiber thickness in nonglaucomatous hypertensive ındividuals. Glokom Katarakt, Cilt: 9 - Sayı: 1, 28–32. https://ajindex.com/articles/226447

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