SavedAdd your journal

Journals / Glokom Katarakt / 2017 / Cilt: 12 - Sayı: 4

Aköz Humör’un Biyokimyasal Özellikleri Üzerine Psödoeksfoliasyon Sendromunun Etkisi

Effect of Pseudoexfoliation Syndrome on Biochemical Characteristics of Aqueous Humour

Yusuf KOÇLUK
Asım KAYIKLIK
Aylin HAKLIGÖR
Emine Alyamaç SUKGEN
Pages
266–270
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In patients with PEX, further studies are needed to analyze the aqueous humor

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: The aim was to evaluate the effect of pseudoexfoliation (PEX) syndrome on the biochemical characteristics of aqueous humour.
📊
Key Findings & Data:Aqueous humor was aspirated from consecutive senile cataract cases with and without PEX.
💡
Conclusion & Impact:In patients with PEX, further studies are needed to analyze the aqueous humor
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: The aim was to evaluate the effect of pseudoexfoliation (PEX) syndrome on the biochemical characteristics of aqueous humour. Materials and Methods: This is a cross-sectional, single-center, comparative study. Aqueous humor was aspirated from consecutive senile cataract cases with and without PEX. The levels of urea, creatinine, glucose, calcium, magnesium, phosphate, chlorine, sodium and potassium were measured in the aqueous humor of both groups. Results: Group-1 included 60 cases without PEX, and Group-2 included 48 cases with PEX. The calcium and chlorine levels were signifi cantly higher in the aqueous humor of the patients with PEX (Group-2) than in the control group (Group-1), whereas the glucose levels were signifi cantly lower in the PEX group than in the control group. The coexistence of nuclear cataracts and PEX in Group-2 was found to be statistically signifi cant. Conclusion: Between the PEX and non-PEX groups, a difference was found in the levels of the biochemical constituents in the aqueous humor. The changes in biochemical features of aqueous humor may be the cause of ocular morbidity. In the future, the ocular complications can be controlled with medicines that regulate biochemical structure of aqueous humor in patients with PEX. The quantity of aqueous humor obtained from the anterior chamber was very limited and thus, only a small number of parameters could be evaluated. In patients with PEX, further studies are needed to analyze the aqueous humor

Özet

Amaç: Bu çalışmanın amacı, aköz humör'un biyokimyasal özellikleri üzerine psödoeksfoliasyon sendromu'nun etkisini değerlendirmektir. Gereç ve Yöntemler: Bu kesitsel, tek merkezli, karşılaştırmalı bir çalışmadır. Aköz humör, psödoeksfoliasyonu olan ve olmayan arka arkaya senil katarakt vakalarından aspire edildi. Üre, kreatinin, glukoz, kalsiyum, magnezyum, fosfat, klor, sodyum ve potasyum seviyeleri, her iki grubun aköz humörlerinde ölçüldü. Bulgular: Grup-1, psödoeksfoliasyonu olmayan 60 hasta içeriyordu, Grup-2, psödoeksfoliasyonlu 48 hasta içeriyordu. Kalsiyum ve klor düzeyleri psödoeksfoliasyonlu hastaların (Grup-2) aköz humörlerinde kontrol grubuna göre istatiksel olarak anlamlı biçimde yüksek idi, buna karşın glukoz düzeyleri psödoeksfoliasyonlu grupta kontrol grubundan anlamlı biçimde düşüktü. Grup-2'de psödoeksfoliasyonla nükleer kataraktın birlikteliği istatiksel olarak anlamlı biçimde yüksekti. Sonuç: Psödoeksfoliasyonu olan ve olmayan gruplar arasında; aköz humör'un biyokimyasal bileşenlerinin düzeylerinde bir farklılık bulundu. Aköz humör'un biyokimyasal özelliklerindeki bu değişiklik oküler morbiditeden sorumlu olabilir. Gelecekte bu oküler komplikasyonlar psödoeksfoliasyonlu hastalarda aköz humörün biyokimyasal yapısını düzenleyecek ilaçlarla kontrol edilebilir. Ön kamaradan elde edilen aköz miktarı çok sınırlıydı ve bu yüzden, sadece belli sayıda parametre değerlendirilebildi. Psödoeksfoliasyonlu hastalarda aköz humörü analiz edecek başka çalışmalara ihtiyaç vardır

🔖

Cite This Article

KOÇLUK, Y., KAYIKLIK, A., HAKLIGÖR, A., SUKGEN, E. A. (2017). Aköz Humör’un Biyokimyasal Özellikleri Üzerine Psödoeksfoliasyon Sendromunun Etkisi. Glokom Katarakt, Cilt: 12 - Sayı: 4, 266–270. https://ajindex.com/articles/226434

References (14)

  1. Tarkkanen A, Kivelä T, John G. Lindberg and the discovery of exfoliation syndrome. Acta OphthalmolScand 2002; 80: 151–4
  2. Schlötzer-Schrehardt U, Dörfl er S, Naumann GO. Immunohistochemical localization of basement membrane components in pseudoexfoliation material of the lens capsule. Curr Eye Res 1992; 11(4): 343‒55
  3. Schlotzer-Schrehardt U, Naumann GO. Ocular and systemic pseudoexfoliation syndrome. Am J Ophthalmol 2006; 141: 921–37
  4. Shingleton BJ, Heltzer J, O’Donoghue MW. Outcomes of phacoemulsifi cation in patients with and without pseudoexfoliation syndrome. J. Cataract Refract Surg 2003; 29: 1080–6
  5. Mönestam E I. Incidence of Dislocation of Intraocular Lenses and Pseudophakodonesis 10 Years after Cataract Surgery. Ophthalmology 2009; 116: 2315-20
  6. Jakobsson G, Zetterberg M, Lundström M, et al. Late dislocation of in-the-bag and out-of-the bag intraocular lenses: Ocular and surgical characteristics and time to lens repositioning. J Cataract Refract Surg 2010; 36: 1637-44
  7. Plateroti P, Plateroti AM, Abdolrahimzadeh S, et al. Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma: A Review of the Literature with Updates on Surgical Management. J Ophthalmol 2015; 2015: 370-1
  8. Borazan M, Karalezli A, Kucukerdonmez C, et al. Aqueous humor and plasma levels of vascular endothelial growth factor and nitric oxide in patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. J Glaucoma 2010; 19: 207-11
  9. Dubey SK, Hejtmancik JF, Krishnadas SR, et al. Evaluation of genetic polymorphisms in clusterin and tumor necrosis factor-alpha genes in South Indian individuals with pseudoexfoliation syndrome. Curr Eye Res 2015; 40: 1218-24
  10. Sorkhabi R, Ghorbanihaghjo A, Ahoor M. Oxidative Stress in Pseudoexfoliation Syndrome. Iranian Journal of Ophthalmology 2011; 23: 27-32
  11. Ohia SE, Opere CA, LedayAM. Pharmacological consequences of oxidative stress in ocular tissues. MutatRes 2005; 579: 22-36
  12. Koliakos GC, Konstas AG, Schlötzer-Schrehardt U et al. Ascorbic acid concentration is reduced in the aqueous humor of patients with exfoliation syndrome. Am J Ophthalmol 2002; 134: 879-83
  13. Koliakos GG, Konstas AG, Schlötzer-Schrehardt U et al. 8-Isoprostaglandin F2a and ascorbic acid concentration in the aqueous humor of patients with exfoliation syndrome. Br J Ophthalmol 2003; 87: 353-6
  14. Boscia F, Grattagliano I, Vendemiale G, Micelli-Ferrari T, Altomare E. Protein oxidation and lens opacity in humans. InvestigOphthalm