Psödoeksfoliasyonlu Hastalarda Yüksek Duyarlıklı C-Reaktif Protein Düzeyleri

Objective & Hypothesis:Amaç: Psödoeksfoliasyon sendromunda (PES) yüksek duyarlıklı C-reaktif proteinin (yd-CRP) sistemik düzeylerini değerlendirmek.

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Key Findings & Data:Gereç ve Yöntemler: Prospektif kontrollü çalışmamıza, PES’lu 13 olgu, psödoeksfoliasyon glokomlu (PEG) 9 olgu ve kontrol grubu olarak 24 sağlıklı birey dahil edildi.

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Conclusion & Impact:Sonuç: PES’lu ve sağlıklı bireyler arasında serum yd-CRP seviyeleri arasında anlamlı farka rastlanmadı.

🔬Design:Survey & Empirical Study

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Amaç: Psödoeksfoliasyon sendromunda (PES) yüksek duyarlıklı C-reaktif proteinin (yd-CRP) sistemik düzeylerini değerlendirmek. Gereç ve Yöntemler: Prospektif kontrollü çalışmamıza, PES’lu 13 olgu, psödoeksfoliasyon glokomlu (PEG) 9 olgu ve kontrol grubu olarak 24 sağlıklı birey dahil edildi. Hastalar 40-80 arasında olup, hiçbirinde sistemik ilaç kullanımı, sistemik hipertansiyon, diabetes mellitus, kardiyovasküler hastalıklar, kronik karaciğer veya böbrek hastalığı, malignensi, infeksiyöz ve infl amatuvar hastalık öyküsü mevcut değildi. Çalışma ve kontrol grubunda yer alan katılımcıların periferik kan örneklerinde yd-CRP düzeyleri ölçüldü. Ayrıca, iki tarafl ı psödoeksfoliatif materyal birikimi, kilo, boy, vücut kitle indeksi, cinsiyet ve yaş parametreleri değerlendirildi. İstatistiksel analiz için Chi-square, Student-t test ve Mann-Whitney U testleri kullanıldı. Bulgular: Gruplar arasında yaş, cinsiyet ve vücut kitle indeksi dağılımı açısından anlamlı farklılık yoktu (p>0.05). Çalışma grubundaki ortanca yd-CRP düzeyi 3.00 mg/dl (0.3-160.9 mg/dl) iken, kontrol grubundaki 3.70 mg/dl (0.4-97.4 mg/dl) idi. İki grup arasında yd-C- RP düzeyleri yönünden anlamlı farklılık yoktu (p>0.05). Sonuç: PES’lu ve sağlıklı bireyler arasında serum yd-CRP seviyeleri arasında anlamlı farka rastlanmadı.

Özet

Purpose: To evaluate the systemic high sensitivity C-reactive protein (hs-CRP) levels in pseudoexfoliation syndrome (PES). Materials and Methods: Thirteen cases with PES, 9 cases with pseudoexfoliation glaucoma (PEG) and 24 control subjects were included to our prospective controlled study. All of the cases were between 40 and 80 year-old and none of them had histories of any systemic medicine, systemic hypertension, diabetes mellitus, cardiovascular disease, chronic liver or kidney disease, any type of malig- nancy, any type of infection and infl ammatory diseases. Results: No statistically signifi cant difference was observed in terms of age, gender and body mass index between groups (p>0.05). The median value of the hs-CRP in the study group was 3.00 mg/dl (0.3-160.9 mg/dl), while it was 3.70 mg/dl (0.4-97.4 mg/dl) in the control group. There was no statistically signifi cant difference between the groups in terms of hs-CRP values (p>0.05). Conclusion: There were no signifi cant changes in hs-CRP levels between the cases with PES compared with healthy subjects.

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Cite This Article

SUNDU, C., YILMAZ, A., FİDANCI, Ş. B., TAMER, L., DİNÇ, E. (2018). Psödoeksfoliasyonlu Hastalarda Yüksek Duyarlıklı C-Reaktif Protein Düzeyleri. Glokom Katarakt, Cilt: 13 - Sayı: 1, 23–26. https://ajindex.com/articles/226421

References (16)

Schlötzer SU, Koca MR, Naumann GO, et al. Pseudoexfoliation syndrome; ocular manifestation of a systemic disorder? Arch Oph- thalmol 1992; 110: 1752-6.
Streeten BW, Li ZY, Wallace RN, et al. Pseudoexfoliative fi bril- lopathy in visceral organs of a patient with pseudoexfoliation syn- drome. Arch Ophthalmol 1992; 110: 1757-62.
Morrison JC, Green WR. Light microscopy of the exfoliation syn- drome. Acta Ophthalmol Suppl 1988; 66: 5-27.
Schumacher S, Schlötzer Schrehardt U, Martus P, et al. Pseudo- exfoliation syndrome and aneurysms of the abdominal aorta. The Lancet 2001; 357: 359-60.
Atalar PT, Atalar E, Kilic H, et al. Impaired systemic endothelial function in patients with pseudoexfoliation syndrome. Internation- al Heart Journal 2006; 47: 77-84.
Elhawy E, Kamthan G, Cecilia Q, et al. Pseudoexfoliation syn- drome, a systemic disorder with ocular manifestations Human Genomics 2012; 6: 22-7.
Bleich S, Roedl J, Von Ahsen N, et al. Elevated homocysteine lev- els in aqueous humor of patients with pseudoexfoliation glauco- ma. Am J Ophthalmol 2004; 138: 162-4.
Siordia JA, Franco J, Golden TR, et al. Ocular pseudoexfoliation syndrome linkage to cardiovascular disease. Curr Cardiol Rep 2016; 18: 61. Mitchell P, Wang JJ, Smith W. Association of exfoliation syn- drome with increased vascular risk. Am J Ophthalmol 1997; 124: 685-7.
Jezovnik M. K, Poredos P. Idiopathic venous thrombosis is related to systemic infl ammatory response and to increased levels of circulating markers of endothelial dysfunction. Int Angiol 2010; 29: 226-31.
Bleich S, Jünemann A, Von Ahsen H. Homocysteine and risk of open angle glaucoma. J Neural Transm 2002; 109: 1499-504.
Puustjarvi T, Blomster H, Kontkanen M, et al. Plasma and aqueous homour levels of homocysteine in exfoliation syn- drome. Graefes Arch Clin Exp Ophthalmol 2004; 242: 149-54
Labarrere CA, Zaloga GP. C-reactive protein: from innocent by- stander to pivotal mediator of atherosclerosis. Am J Med 2004; 117: 499-507.
Torres JL, Ridker PM. Clinical use of high sensitivity C-reactive protein for the prediction of adverse cardiovascular events. Curr Opin Cardiol 2003; 18: 471-8.
Jialal I, Devaraj S, Venugopal SK. C-reactive protein: risk marker or mediator in atherothrombosis? Hypertension. 2004; 44: 6-11.
Yüksel N, Pirhan D, Altıntaş O, et al. Systemic high-sensitivity C-reactive protein level in pseudoexfoliation syndrome and pseu- doexfoliation glaucoma. J Glaucoma 2010; 19: 373-6.
Mocan MC, Dikmetas O, İrkeç M. Serum reactive