Journals / Glokom Katarakt / 2020 / Cilt: 15 - Sayı: 1

Over-dose Oral Moxifl oxacin Related Bilateral Acute Iris Transillumination in a Short Period

Pages
51–54
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Although the relationship between oral fl uoroquinolones and uveitis is still controversial, the presented case with severe signs and symptoms shortly after taking high dose oral moxifl oxacin supports this relation.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:W e aimed to report a case of bilateral acute iris transillumination and pigment dispersion related to oral moxifl oxacin that used a higher dose than recommended.
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Key Findings & Data:A 43-year-old woman who presented with redness, pain, blurred vision, and high intraocular pressure (IOP) 10 hours after taking six oral moxifl oxacin tablets because of pneumonia was referred to our clinic for differential diagnosis.
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Conclusion & Impact:Although the relationship between oral fl uoroquinolones and uveitis is still controversial, the presented case with severe signs and symptoms shortly after taking high dose oral moxifl oxacin supports this relation.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

W e aimed to report a case of bilateral acute iris transillumination and pigment dispersion related to oral moxifl oxacin that used a higher dose than recommended. A 43-year-old woman who presented with redness, pain, blurred vision, and high intraocular pressure (IOP) 10 hours after taking six oral moxifl oxacin tablets because of pneumonia was referred to our clinic for differential diagnosis. Slit-lamp examination revealed conjunctival hyperemia, endothelial dusting, fl oating anterior chamber pigments, and diffuse transillumination for both irises. IOP was in the normal range with both topical and systemic antiglaucomatous treatment. The patient experienced several fl are-ups within three months, especially in the fi rst month. The pigment cells decreased in both the anterior chamber and trabecular meshwork, however, diffuse transillumination is still continuing in both eyes. Although the relationship between oral fl uoroquinolones and uveitis is still controversial, the presented case with severe signs and symptoms shortly after taking high dose oral moxifl oxacin supports this relation.

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Cite This Article

ESER-OZTURK, H., SÜLLÜ, Y. (2020). Over-dose Oral Moxifl oxacin Related Bilateral Acute Iris Transillumination in a Short Period. Glokom Katarakt, Cilt: 15 - Sayı: 1, 51–54. https://ajindex.com/articles/226412

References (11)

  1. Bringas Calvo R, Iglesias Cortinas D. Acute and bilateral uveitis secondary to moxifl oxacin. Arch Soc Esp Oftalmol. 2004;79:357-9
  2. Hinkle DM, Dacey MS, Mandelcorn E, et al. Bilateral uveitis associated with fl uoroquinolone therapy. Cutan Ocul Toxicol. 2012;31:111-6
  3. Morshedi RG, Bettis DI, Moshirfar M, et al. Bilateral acute iris transillumination following systemic moxifl oxacin for respiratory illness: report of two cases and review of the literature. Ocul Immunol Infl amm. 2012;20:266-72
  4. Knape RM, Sayyad FE, Davis JL. Moxifl oxacin and bilateral acute iris transillumination. J Ophthalmic Infl amm Infect. 2013;3:10
  5. Ozge G, Bayer A, Mumcuoglu T. Sistemik fl orokinolon kullanimina bagli bilateral akut iris degisiklikleri saptanan iki olgu. Glo-Kat 2017;12:137-140 6. Donmez O, Arikan G, Kaya M, Gunenc U. Bilateral akut iris transilluminasyonu: Olgu sunumu. Glo-Kat 2018;13:196-200 7. Eadie B, Etminan M, Mikelberg FS. Risk for uveitis with oral moxifl oxacin: a comparative safety study. JAMA Ophthalmol. 2015;133:81-4
  6. Forooghian F, Maberley D, Albiani DA, et al. Uveitis risk following oral fl uoroquinolone therapy: a nested case-control Study. Ocul Immunol Infl amm. 2013;21:390-3
  7. Sandhu HS, Brucker AJ, Ma L, et al. Oral Fluoroquinolones and the Risk of Uveitis. JAMA Ophthalmol. 2016;134:38-43
  8. Tugal-Tutkun I, Onal S, Garip A, et al. Bilateral acute iris transillumination. Arch Ophthalmol. 2011;129:1312-9
  9. Tugal-Tutkun I, Araz B, Taskapili M, et al. Bilateral acute depigmentation of the iris: report of 26 new cases and four-year follow-up of two patients. Ophthalmology. 2009;116:1552-7
  10. Siefert HM, Kohlsdorfer C, Steinke W, et al. Pharmacokinetics of the 8-methoxyquinolone, moxifl oxacin: tissue distribution in male rats. J Antimicrob Chemother. 1999;43 Suppl B:61-7
  11. Hariprasad SM, Shah GK, Mieler WF, et al. Vitreous and aqueous penetration of orally administered moxifl oxacin in humans. Arch Ophthalmol 2006;124:178-82